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Elevated platelet vesicular monoamine transporter 2 in former heroin addicts maintained on methadone

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Summary.

The brain vesicular monoamine transporter (VMAT2) is essential for neuronal monoamine storage and regulation of monoaminergic neurotransmission. We demonstrated previously a high degree of similarity between the pharmacodynamic characteristics of platelet and brain VMAT2. Opioids induce increase of dopamine release in limbic structures. In the present study we assessed the VMAT2 pharmacodynamic characteristics using high affinity [3H]dihydrotetrabenazine (TBZOH) binding to platelets of former male heroin addicts maintained on methadone (n = 12) compared to age-matched healthy controls (n = 13). A significant increase (19%, p < 0.05) in platelet VMAT2 density (Bmax) was observed in the methadone treated patients compared to controls. There was no significant difference in the affinity of [3H]TBZOH to its platelet binding site. The increased VMAT2 density may reflect a compensatory attempt to prevent vesicular depletion due to chronic methadone exposure.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    K. Schwartz & M. Rehavi

  2. Jaffa Centre for the Treatment of Drug Victims, Tel Aviv, Israel

    I. Herman & G. Peer

  3. Geha Psychiatric Hospital and Felsenstein Medical Research Center, Beilinson Campus, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    A. Weizman

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  1. K. Schwartz
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  2. I. Herman
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  3. G. Peer
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  4. A. Weizman
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  5. M. Rehavi
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Schwartz, K., Herman, I., Peer, G. et al. Elevated platelet vesicular monoamine transporter 2 in former heroin addicts maintained on methadone. J Neural Transm 114, 281–284 (2007). https://doi.org/10.1007/s00702-006-0527-1

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  • DOI: https://doi.org/10.1007/s00702-006-0527-1

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