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Screening for cognitive impairment in Parkinson’s disease – which marker relates to disease severity?

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Summary.

The frequency and pattern of cognitive deficits in Parkinson’s disease (PD) is under discussion. We assessed 157 consecutive subjects with PD (66.4 ± 8.9 years (mean ± standard deviation); average duration of disease 3.5 ± 1.3 years; average Hoehn and Yahr stage 2.4 ± 0.9) diagnosed in centers specialized for the diagnosis and treatment of PD with brief tests for memory (Memory Impairment Screen), attention (Letter Sorting Test) and semantic fluency (category animals). Impaired memory was observed in about one half of the subjects regardless of severity of disease as assessed by staging according to Hoehn and Yahr. With greater severity, free recall was impaired and subjects required the cues to recall the items. Performance in the Letter Sorting Test and the semantic fluency task declined with increasing Hoehn and Yahr stage, also. We conclude that cognitive deficits are frequent in PD. Further analyses reveal that even in selected screening tests (e.g. semantic fluency) a significant impairment with increasing disease severity (Hoehn and Yahr stage) as opposed to disease duration alone can be demonstrated.

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References

  • T Azuma RF Cruz KA Bayles CK Tomoeda EB Montgomery SuffixJr (2003) ArticleTitleA longitudinal study of neuropsychological change in individuals with Parkinson’s disease Int J Geriatr Psychiatry 18 1115–1120 Occurrence Handle14677144 Occurrence Handle10.1002/gps.1022

    Article  PubMed  Google Scholar 

  • A Baddeley (1992) ArticleTitleWorking memory Science 255 556–559 Occurrence Handle1736359 Occurrence Handle1:STN:280:By2C2c7otFE%3D

    PubMed  CAS  Google Scholar 

  • A Baddeley (2000) ArticleTitleThe episodic buffer: a new component of working memory? Trends Cogn Sci 4 417–423 Occurrence Handle11058819 Occurrence Handle10.1016/S1364-6613(00)01538-2

    Article  PubMed  Google Scholar 

  • U Beinhoff V Hilbert D Bittner G Gron MW Riepe (2005) ArticleTitleScreening for cognitive impairment: a triage for outpatient care Dement Geriatr Cogn Disord 20 278–285 Occurrence Handle16158010 Occurrence Handle10.1159/000088249

    Article  PubMed  Google Scholar 

  • JL Bosboom D Stoffers EC Wolters (2004) ArticleTitleCognitive dysfunction and dementia in Parkinson’s disease J Neural Transm 111 1303–1315 Occurrence Handle15480840 Occurrence Handle1:STN:280:DC%2BD2crhtVKmsQ%3D%3D Occurrence Handle10.1007/s00702-004-0168-1

    Article  PubMed  CAS  Google Scholar 

  • EK Breen (1993) ArticleTitleRecall and recognition memory in Parkinson’s disease Cortex 29 91–102 Occurrence Handle8472561 Occurrence Handle1:STN:280:ByyB3s%2Fpt1Q%3D

    PubMed  CAS  Google Scholar 

  • RG Brown CD Marsden (1984) ArticleTitleHow common is dementia in Parkinson’s disease? Lancet 2 1262–1265 Occurrence Handle6150288 Occurrence Handle1:STN:280:BiqD2MbptFI%3D Occurrence Handle10.1016/S0140-6736(84)92807-1

    Article  PubMed  CAS  Google Scholar 

  • P Bublak U Muller G Gron M Reuter DY von Cramon (2002) ArticleTitleManipulation of working memory information is impaired in Parkinson’s disease and related to working memory capacity Neuropsychology 16 577–590 Occurrence Handle12382995 Occurrence Handle1:STN:280:DC%2BD38nisFCitw%3D%3D Occurrence Handle10.1037/0894-4105.16.4.577

    Article  PubMed  CAS  Google Scholar 

  • H Buschke G Kuslansky M Katz WF Stewart MJ Sliwinski HM Eckholdt RB Lipton (1999) ArticleTitleScreening for dementia with the memory impairment screen Neurology 52 231–238 Occurrence Handle9932936 Occurrence Handle1:STN:280:DyaK1M7ivFOitA%3D%3D

    PubMed  CAS  Google Scholar 

  • B Desgranges JC Baron F Eustache (1998) ArticleTitleThe functional neuroanatomy of episodic memory: the role of the frontal lobes, the hippocampal formation, and other areas Neuroimage 8 198–213 Occurrence Handle9740762 Occurrence Handle1:STN:280:DyaK1cvhsVKlsw%3D%3D Occurrence Handle10.1006/nimg.1998.0359

    Article  PubMed  CAS  Google Scholar 

  • M Emre (2003) ArticleTitleWhat causes mental dysfunction in Parkinson’s disease? Mov Disord 18 IssueIDSuppl 6 S63–S71 Occurrence Handle14502658 Occurrence Handle10.1002/mds.10565

    Article  PubMed  Google Scholar 

  • M Emre D Aarsland A Albanese EJ Byrne G Deuschl PP De Deyn F Durif J Kulisevsky T van Laar A Lees W Poewe A Robillard MM Rosa E Wolters P Quarg S Tekin R Lane (2004) ArticleTitleRivastigmine for dementia associated with Parkinson’s disease N Engl J Med 351 2509–2518 Occurrence Handle15590953 Occurrence Handle1:CAS:528:DC%2BD2cXhtVGksbnF Occurrence Handle10.1056/NEJMoa041470

    Article  PubMed  CAS  Google Scholar 

  • T Erkinjuntti T Ostbye R Steenhuis V Hachinski (1997) ArticleTitleThe effect of different diagnostic criteria on the prevalence of dementia N Engl J Med 337 1667–1674 Occurrence Handle9385127 Occurrence Handle1:STN:280:DyaK1c%2FjsF2ktg%3D%3D Occurrence Handle10.1056/NEJM199712043372306

    Article  PubMed  CAS  Google Scholar 

  • WP Goldman JD Baty VD Buckles S Sahrmann JC Morris (1998) ArticleTitleCognitive and motor functioning in Parkinson disease: subjects with and without questionable dementia Arch Neurol 55 674–680 Occurrence Handle9605724 Occurrence Handle1:STN:280:DyaK1c3ms1Olsw%3D%3D Occurrence Handle10.1001/archneur.55.5.674

    Article  PubMed  CAS  Google Scholar 

  • AM Graceffa GA Carlesimo A Peppe C Caltagirone (1999) ArticleTitleVerbal working memory deficit in Parkinson’s disease subjects Eur Neurol 42 90–94 Occurrence Handle10473980 Occurrence Handle1:STN:280:DyaK1Mvgs1KgtQ%3D%3D Occurrence Handle10.1159/000069417

    Article  PubMed  CAS  Google Scholar 

  • J Green WM McDonald JL Vitek M Evatt A Freeman M Haber RA Bakay S Triche B Sirockman MR DeLong (2002) ArticleTitleCognitive impairments in advanced PD without dementia Neurology 59 1320–1324 Occurrence Handle12427877 Occurrence Handle1:STN:280:DC%2BD38nmslKmsg%3D%3D

    PubMed  CAS  Google Scholar 

  • JD Henry JR Crawford (2004) ArticleTitleVerbal fluency deficits in Parkinson’s disease: a meta-analysis J Int Neuropsychol Soc 10 608–622 Occurrence Handle15327739 Occurrence Handle10.1017/S1355617704104141

    Article  PubMed  Google Scholar 

  • DM Jacobs K Marder LJ Cote M Sano Y Stern R Mayeux (1995) ArticleTitleNeuropsychological characteristics of preclinical dementia in Parkinson’s disease Neurology 45 1691–1696 Occurrence Handle7675228 Occurrence Handle1:STN:280:ByqH3crmt1w%3D

    PubMed  CAS  Google Scholar 

  • NA Leopold AJ Borson (1997) ArticleTitleAn alphabetical ‘WORLD’. A new version of an old test Neurology 49 1521–1524 Occurrence Handle9409339 Occurrence Handle1:STN:280:DyaK1c%2Fntlyjtg%3D%3D

    PubMed  CAS  Google Scholar 

  • G Levy DM Jacobs MX Tang LJ Cote ED Louis B Alfaro H Mejia Y Stern K Marder (2002) ArticleTitleMemory and executive function impairment predict dementia in Parkinson’s disease Mov Disord 17 1221–1226 Occurrence Handle12465060 Occurrence Handle10.1002/mds.10280

    Article  PubMed  Google Scholar 

  • SJ Lewis A Dove TW Robbins RA Barker AM Owen (2003) ArticleTitleCognitive impairments in early Parkinson’s disease are accompanied by reductions in activity in frontostriatal neural circuitry J Neurosci 23 6351–6356 Occurrence Handle12867520 Occurrence Handle1:CAS:528:DC%2BD3sXlvVCgsL0%3D

    PubMed  CAS  Google Scholar 

  • M Lezak (1995) Neuropsychological assessment Oxford University Press New York, Oxford

    Google Scholar 

  • R Mayeux Y Stern R Rosenstein K Marder A Hauser L Cote S Fahn (1988) ArticleTitleAn estimate of the prevalence of dementia in idiopathic Parkinson’s disease Arch Neurol 45 260–262 Occurrence Handle3341950 Occurrence Handle1:STN:280:BieC3szks1U%3D

    PubMed  CAS  Google Scholar 

  • MW Riepe S Riss D Bittner R Huber (2004) ArticleTitleScreening for cognitive impairment in patients with acute stroke Dement Geriatr Cogn Disord 17 49–53 Occurrence Handle14560065 Occurrence Handle10.1159/000074082

    Article  PubMed  Google Scholar 

  • D Weintraub PJ Moberg WC Culbertson JE Duda MB Stern (2004) ArticleTitleEvidence for impaired encoding and retrieval memory profiles in Parkinson disease Cogn Behav Neurol 17 195–200 Occurrence Handle15622014

    PubMed  Google Scholar 

  • EA Werber JM Rabey (2001) ArticleTitleThe beneficial effect of cholinesterase inhibitors on patients suffering from Parkinson’s disease and dementia J Neural Transm 108 1319–1325 Occurrence Handle11768630 Occurrence Handle1:CAS:528:DC%2BD38XhsVSqt7c%3D Occurrence Handle10.1007/s007020100008

    Article  PubMed  CAS  Google Scholar 

  • DJ Zgaljardic NS Foldi JC Borod (2004) ArticleTitleCognitive and behavioral dysfunction in Parkinson’s disease: neurochemical and clinicopathological contributions J Neural Transm 111 1287–1301 Occurrence Handle15480839 Occurrence Handle1:STN:280:DC%2BD2crhtVKmsA%3D%3D Occurrence Handle10.1007/s00702-004-0178-z

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, Charité Universitätsmedizin, Berlin, Germany

    M. W. Riepe

  2. Department of Neurology, University of Ulm, Beelitz, Germany

    J. Kassubek

  3. Movement Disorder Clinic, Beelitz Heilstätten, Beelitz, Germany

    G. Ebersbach

  4. Clinical Research and Development, Novartis, Nuremberg, Germany

    F. Tracik

Authors
  1. M. W. Riepe
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  2. J. Kassubek
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  3. F. Tracik
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  4. G. Ebersbach
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Riepe, M., Kassubek, J., Tracik, F. et al. Screening for cognitive impairment in Parkinson’s disease – which marker relates to disease severity?. J Neural Transm 113, 1463–1468 (2006). https://doi.org/10.1007/s00702-006-0433-6

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  • DOI: https://doi.org/10.1007/s00702-006-0433-6

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