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Family-based association studies of the TCP1 gene and schizophrenia in the Chinese Han population

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Summary.

A previous case-control study by Yang et al. indicated that the TCP1 gene in 6q25 was associated with schizophrenia in the Han population. To replicate this result, we selected eight SNPs (rs2273828, rs3818298, rs1547094, rs1547093, rs2295898, rs2295899, rs4832, rs15982) spanning the whole gene and performed a family-based study using 325 trios samples. Our transmission disequilibrium test showed neither allele nor haplotype association with schizophrenia, and suggests that the TCP1 locus is not associated with schizophrenia in the Chinese population. Since 6q25 has consistently been found to be a susceptible region for schizophrenia, we suggest that other genes within this region should be the focus of attention.

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Authors and Affiliations

  1. Bio-X Center, Shanghai Jiao Tong University, Shanghai, P.R. China

    W. Tang, Y. Shi, J. Liu, X. Zhao, R. Tang, J. Du, J. Zhang & G. He

  2. Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

    W. Tang, Y. Shi, J. Liu, X. Zhao, R. Tang, J. Du, J. Zhang, G. He & L. He

  3. College of Science and Technology, Shanghai Jiao Tong University, Shanghai, P.R. China

    P. Liang

  4. Shanghai Institute of Mental Health, Shanghai, P.R. China

    G. Feng

  5. NHGG, Bio-X Center, Shanghai Jiao Tong University, Shanghai, P.R. China

    L. He

  6. Changchun Kaixuan Hospital, Changchun, China

    L. Yan

  7. Xi’an Institute of Mental Health, Xi’an, China

    Y. Xing

  8. Jilin Institute of Brain Research, Jilin, China

    S. Zhu

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  1. W. Tang
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  2. Y. Shi
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  3. G. Feng
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  4. L. Yan
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  9. R. Tang
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  13. P. Liang
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The first and second authors contributed equally to this work

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Tang, W., Shi, Y., Feng, G. et al. Family-based association studies of the TCP1 gene and schizophrenia in the Chinese Han population. J Neural Transm 113, 1537–1543 (2006). https://doi.org/10.1007/s00702-005-0419-9

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  • DOI: https://doi.org/10.1007/s00702-005-0419-9

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