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Failure to find association between TRAR4 and schizophrenia in the Chinese Han population

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Summary.

The TRAR4 gene locates in SCZD5 (MIM 603175), which a number of studies have linked with schizophrenia. One recent study suggested that three TRAR4 variants (M1: rs4305745, P = 0.0014; M2: rs6903874, P = 0.0026; M3: rs6937506, P = 0.0052) in the 3′-UTR were associated with schizophrenia. To replicate these findings, we conducted a family-based association study within a sample of 235 Chinese Han trios. However, we didn’t find significant evidence of preferential transmission of the three variants across all the trios (all P values >0.2). Thus, we conclude that TRAR4 is not a major or independent determinant in the occurrence of schizophrenia in the Chinese Han population.

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Authors and Affiliations

  1. Bio-X Center, Shanghai Jiao Tong University, Shanghai, China

    S. Duan, J. Du, Q. Xing, H. Wang, S. Wu, Q. Chen, X. Li & X. Li

  2. Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China

    S. Duan, J. Du, Q. Xing, H. Wang, S. Wu, Q. Chen, X. Li, X. Li & L. He

  3. Shanghai Institute of Mental Health, Shanghai, China

    Y. Xu & G. Feng

  4. Center for Neurologic Diseases, Brigham and Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA, USA

    J. Shen

  5. NHGG, Bio-X Center, Shanghai JiaoTong University, Shanghai, China

    L. He

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  1. S. Duan
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  2. J. Du
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  3. Y. Xu
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  4. Q. Xing
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  5. H. Wang
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  7. Q. Chen
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  8. X. Li
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  9. X. Li
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  10. J. Shen
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  11. G. Feng
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  12. L. He
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These authors have contributed equally to this work

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Duan, S., Du, J., Xu, Y. et al. Failure to find association between TRAR4 and schizophrenia in the Chinese Han population. J Neural Transm 113, 381–385 (2006). https://doi.org/10.1007/s00702-005-0335-z

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  • DOI: https://doi.org/10.1007/s00702-005-0335-z

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