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Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients

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Summary.

Relationships between the serotonin transporter promoter polymorphism (5-HTTLPR), platelet serotonin transporter (SERT) binding and clinical phenotype were examined in 32 suicidal and 28 non-suicidal Ashkenazi Israeli adolescent psychiatric inpatients. The 5-HTTLPR polymorphism was not associated with transporter binding or with suicidality or other clinical phenotypes. However, in the suicidal group, a significant positive correlation between platelet SERT density and anger scores (n=32, r=.40; p=.027) and a negative correlation between platelet count and trait anxiety (n=32, r=−.42; p=.034) were observed.

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Authors and Affiliations

  1. Adolescent Inpatient Department and Research Unit, Geha Mental Health Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    G. Zalsman, M. Peskin, M. Vekslerchik & A. Weizman

  2. Division of Neuroscience, Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY, USA

    G. Zalsman & L. Sher

  3. Child Study Center, Yale University, New Haven, CT, USA

    G. M. Anderson & R. A. King

  4. Felsenstein Medical Research Center, Petach Tikva, and Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

    A. Frisch, E. Michaelovsky & A. Weizman

  5. Behavioral Sciences Department, The College of Judea and Samaria, Ariel, Israel

    E. Sommerfeld

  6. Feinberg Child Study Center, Psychiatric Department, Shneider’s Children Hospital, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Israel

    A. Apter

Authors
  1. G. Zalsman
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  2. G. M. Anderson
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  3. M. Peskin
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  4. A. Frisch
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  5. R. A. King
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  6. M. Vekslerchik
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  7. E. Sommerfeld
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  8. E. Michaelovsky
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  9. L. Sher
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  10. A. Weizman
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  11. A. Apter
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Zalsman, G., Anderson, G., Peskin, M. et al. Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients. J Neural Transm 112, 309–315 (2005). https://doi.org/10.1007/s00702-004-0244-6

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  • DOI: https://doi.org/10.1007/s00702-004-0244-6

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