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Interleukin-1 gene cluster polymorphisms and risk of Alzheimer’s disease in Chinese Han population

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Summary.

Interleukin-1 (IL-1) has been implicated as a key cytokine in Alzheimer’s disease (AD) pathogenesis. IL-1 gene polymorphisms, especially IL-1A C(−889)T polymorphism, have been suggested to be associated with AD risk and onset age. To determine if IL-1 polymorphisms are genetic risk factors for developing AD in Chinese Mainland population, we analyzed IL-1A (−889), IL-1B (−511) and IL-1RN variable number of tandem repeat (VNTR) polymorphisms in a sample of 145 sporadic AD patients and 181 healthy controls. Our data revealed that the three polymorphisms in IL-1 gene cluster might not play a key role in AD pathogenesis in Chinese Mainland Han population.

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Authors and Affiliations

  1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing, P.R. China

    X.-Q. Li, J.-W. Zhang & D. Chen

  2. Department of Neurology, Peking Union Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China

    Z.-X. Zhang

  3. Department of Neurology, the First Affiliated Hospital, Xi’an Medical University, Shaanxi Province, P.R. China

    Q.-M. Qu

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  1. X.-Q. Li
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  2. J.-W. Zhang
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  3. Z.-X. Zhang
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  4. D. Chen
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  5. Q.-M. Qu
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Li, XQ., Zhang, JW., Zhang, ZX. et al. Interleukin-1 gene cluster polymorphisms and risk of Alzheimer’s disease in Chinese Han population. J Neural Transm 111, 1183–1190 (2004). https://doi.org/10.1007/s00702-004-0148-5

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  • DOI: https://doi.org/10.1007/s00702-004-0148-5

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