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The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

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Summary.

To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3,4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

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Authors and Affiliations

  1. Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland, , , , , , PL

    J. Vetulani & I. Nalepa

  2. Institute of Neuroscience, C.N.R., Psychobiology and Psychopharmacology, Rome, Italy, , , , , , IN

    F. Pavone & V. Borghi

  3. Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland, , , , , , PL

    B. Przewłocka

Authors
  1. J. Vetulani
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  2. F. Pavone
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  3. B. Przewłocka
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  4. V. Borghi
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  5. I. Nalepa
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Received April 14, 2003; accepted July 9, 2003 Published online September 15, 2003

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Vetulani, J., Pavone, F., Przewłocka, B. et al. The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice. J Neural Transm 110, 1205–1213 (2003). https://doi.org/10.1007/s00702-003-0037-3

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  • DOI: https://doi.org/10.1007/s00702-003-0037-3

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