Skip to main content
SpringerLink
Log in

Specific modulation of sigma binding sites by the anxiolytic drug opipramol

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

 The atypical anxiolytic and antidepressive drug opipramol binds with high affinity to σ1 and somewhat lower affinity to σ2 sites. After subchronic treatment, opipramol significantly down-regulated σ2 but not σ1 sites. This effect was not seen for imipramine, citalopram, and reboxetine under similar conditions. On the other hand, only imipramine reduced the number of σ1 sites. It is suggested that effects at σ2 sites are involved in the anxiolytic properties of opipramol.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Pharmacology, Biocenter University Frankfurt, Frankfurt, Germany, , , , , , DE

    G. Holoubek & W. E. Müller

Authors
  1. G. Holoubek
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. E. Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received February 7, 2003; accepted March 24, 2003 Published online July 30, 2003

Rights and permissions

Reprints and permissions

About this article

Cite this article

Holoubek, G., Müller, W. Specific modulation of sigma binding sites by the anxiolytic drug opipramol. J Neural Transm 110, 1169–1179 (2003). https://doi.org/10.1007/s00702-003-0019-5

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-003-0019-5

Search

Navigation