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Possible increased risk for Alzheimer's disease associated with neprilysin gene

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Summary.

Neprilysin has recently been reported to be the major physiological Aβ-degradating enzyme. In this study we describe a new biallelic polymorphism in the 3′UTR of the neprilysin gene in a representative population sample. The *159C/C genotype was found to be associated with an increased risk for Alzheimer's disease in an age-dependent manner. Adjusting for sex and APOE status, an odds ratio of 2.74 (p < 0.05) was observed among patients under 75 years old.

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Authors and Affiliations

  1.  Unitat de Biologia Evolutiva, and, , , , , , ES

    J. Clarimón, J. Bertranpetit & D. Comas

  2.  Unitat de Senyalització Cellular, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, and, , , , , , ES

    F. J. Muñoz

  3.  Fundació ACE. I.C. Neurociències Aplicades, and, , , , , , ES

    M. Boada & L. Tàrraga

  4.  Respiratory and Environmental Research Unit, IMIM and Universitat Pompeu Fabra, Barcelona, Spain, , , , , , ES

    J. Sunyer

Authors
  1. J. Clarimón
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  2. F. J. Muñoz
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  3. M. Boada
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  4. L. Tàrraga
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  5. J. Sunyer
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  6. J. Bertranpetit
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  7. D. Comas
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Additional information

Received October 2, 2002; accepted December 9, 2002 Published online February 19, 2003

Acknowledgements We would like to thank A. Andrés, F. Calafell (Universitat Pompeu Fabra), and B. Cormand (Universitat de Barcelona) for useful comments and fruitful discussion. We also thank M. Vallés for technical assistance and the ACE staff for their invaluable help. This study was supported by grants from DGICT (PB98-1064, and BOS2001-0794) and by the Generalitat de Catalunya, Grup de Recerca Consolidat 2001SGR00285.

Authors' address: Dr. D. Comas, Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, C/ Doctor Aiguader 80, Barcelona 08003, Catalonia, Spain, e-mail: david.comas@cexs.upf.es

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Clarimón, J., Muñoz, F., Boada, M. et al. Possible increased risk for Alzheimer's disease associated with neprilysin gene. J Neural Transm 110, 651–657 (2003). https://doi.org/10.1007/s00702-002-0807-3

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  • DOI: https://doi.org/10.1007/s00702-002-0807-3

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