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Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on- and off-conditions with FDG-PET

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Summary.

In order to compare the effects of high-frequency stimulation of the subthalamic nucleus (STN-DBS) and a levodopa-challenge on cerebral metabolic activity, we conducted PET scans with [18F]2-fluoro-2-deoxyglucose (FDG) in the drug- and stimulation- on- and off-condition in a single patient suffering from advanced PD. Our data revealed evidence for improved thalamocortical processing released from inhibition by overactive basal ganglia output nuclei in both on-conditions. While levodopa also led to a reduction of lentiform hyperactivity, effective STN stimulation seemed to interfere with distinct cerebellar and limbic circuits.

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Authors and Affiliations

  1.  Department of Neurology, and, , , , , , DE

    R. Hilker, A. Thiel, M. Ghaemi, K. Herholz & W.-D. Heiss

  2.  Department of Stereotaxy and Functional Neurosurgery, Medical University of Cologne, and, , , , , , DE

    J. Voges & V. Sturm

Authors
  1. R. Hilker
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  2. J. Voges
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  3. A. Thiel
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  4. M. Ghaemi
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  5. K. Herholz
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  6. V. Sturm
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  7. W.-D. Heiss
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Additional information

Received November 2, 2001; accepted January 15, 2002 Published online June 28, 2002

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Hilker, R., Voges, J., Thiel, A. et al. Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on- and off-conditions with FDG-PET. J Neural Transm 109, 1257–1264 (2002). https://doi.org/10.1007/s00702-002-0696-5

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  • DOI: https://doi.org/10.1007/s00702-002-0696-5

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