Summary
This is the first case of multiple (triple) pituitary micro-adenomas documented by magnetic resonance imaging (MRI) in a living patient and treated by a transsphenoidal microsurgical approach. The patient, a 37-year-old woman, complained of a long history of bifrontal headache, weight gain and oligomenorrhea. Physical examination revealed moderate hirsutism and a slight fat pad overlying the vertebrae. Routine laboratory studies and endocrinological biochemical investigations were normal. A gadolinium-enhanced MRI of the pituitary region revealed three intrapituitary micro-adenomas. A transsphenoidal microsurgical approach to the pituitary gland was carried out and micro-adenomas were completely removed one at a time. One year follow-up showed complete resolution of clinical symptoms and signs and normal biochemical parameters of pituitary function.
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Salpietro, F., Alafaci, C., Grasso, G. et al. Transsphenoidal Microsurgical Selective Removal of Multiple (Triple) Adenomas of the Pituitary Gland. Acta Neurochir (Wien) 141, 425–428 (1999). https://doi.org/10.1007/s007010050319
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DOI: https://doi.org/10.1007/s007010050319