Abstract
Background and Objectives
Meningioma is one of the most common neoplasm of the central nervous system. To describe the epidemiology of meningioma operated in France and, to assess grading and histopathological variability among the different neurosurgical centres.
Methods
We processed the French Brain Tumour Database (FBTDB) to conduct a nationwide population-based study of all histopathologically confirmed meningiomas between 2006 and 2015.
Results
30,223 meningiomas cases were operated on 28,424 patients, in 61 centres. The average number of meningioma operated per year in France was 3,022 (SD ± 122). Meningioma was 3 times more common in women (74.1% vs. 25.9%). The incidence of meningioma increased with age and, mean age at surgery was 58.5 ± 13.9 years. Grade 1, 2, and 3 meningiomas accounted for 83.9%, 13.91% and, 2.19% respectively. There was a significant variability of meningioma grading by institutions, especially for grade 2 which spanned from 5.1% up to 22.4% (p < 0.001). Moreover, the proportion of grade 2 significantly grew over the study period (p < 0.001). There was also a significant variation in grade 1 subtypes diagnosis among the institutions (p < 0.001). 89.05% of the patients had solely one meningioma surgery, 8.52% two and, 2.43% three or more. The number of surgeries was associated to the grade of malignancy (p < 0.001).
Conclusion
The incidence of meningioma surgery increased with age and, peaked at 58.5 years. They were predominantly benign with meningothelial subtype being the most common. However, there was a significant variation of grade 1 subtypes diagnosis among the centres involved. The proportion of grade 2 meningioma significantly grew over the study time, on contrary to malignant meningioma proportion, which remained rare and, stable over time around 2%. Likewise, there was a significant variability of grade 2 meningioma rate among the institutions.
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Data availability
Restricted, the authors do not have permission to share data. The datasets generated and analysed for the study are not publicly available. Under French law and regulations, patient-level data from the French Brain Tumour Database cannot be made available.
Code availability
On demand.
Abbreviations
- ADICAP:
-
Association for the Development of Information Technology in Cytology, Anatomy and Pathology
- CI:
-
Confidence Interval
- CNS:
-
Central Nervous System
- FBTDB:
-
French Brain Tumour DataBase
- ICD-10:
-
International Classification of Diseases, tenth revision
- ICD-0-3:
-
International Classification of Diseases for Oncology, third revision
- IQR:
-
Inter Quartile Range
- PCNST:
-
Primary Central Nervous System Tumour
- SD:
-
Standard Deviations
- WHO:
-
World Health Organization
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Acknowledgements
Mrs. Segolène Van Outheusden, London, England, United Kingdom, for its manuscript review, English proofreading, grammar and spelling check. We would like thank the patients and their families. We also are grateful to all neuropathologists, neurosurgeons and other participants who helped and completed the cards for the record of PCNSTs in France. The full list of neurosurgeons and pathologists who help to build the FBTDB is provided below:
Neurosurgeons:
Abi Lahoud G., Aboukais R., Achim V., Adetchessi T., Aesch B., Agha M., Aghakhani N., Al Hallak R., Albert A., Aldea S., Ali Benali M., Ali Y., Allano V., Allaoui M., Alliez J.R., Almairac F., Aouad N., Arthuis F., Ashraf A., Assaker R., Atta M., Auque J., Autricque A., Balossier A., Barat J.L., Barnoud Croix, Baroncini M., Barral-Clavel F., Barrey C., Bataille B., Bauchet L., Baujat X., Baussart B., Bayram M., Bazin A., Beaudic Y., Beaurain J., Beccaria K., Bedou G., Bekaert O., Belaid H., Belliard H., Bellow F., Beltechi R., Ben Ismaïl M., Benazza A., Benbrahi A., Benezech J., Benhaddou-Benkirane L., Benhima H., Benmekhbi M., Bennis S., Berhouma M., Bernard C., Bernard M.H., Bernat A.L., Berthelot J.L., Besson G., Billant J.B., Billon-Grand R., Bitar A., Bizette C., Blanc J.L., Blanquet A., Blauwblomme T., Blond S., Blondet E., Boch A.L., Boetto J., Boetto S., Boissonnet H., Boniface G., Bord E., Borha A., Botella C., Bouali I., Bouazza S., Bougeard R., Bouillot P., Bouras A., Bourgeois P., Bousigue J.Y., Bousquet C., Bousquet O., Bousquet P., Boyer F., Boyer P., Brassier G., Brauge D., Bresson D., Brie, Brunon J., Buffenoir Billet K., Buisset N., Cabal P., Caillaud P., Caire F., Cam P., Cao C., Capel C., Capelle L., Cardarelli M., Carlucci L., Carpentier A., Carron R., Cebula H., Cesari J.B., Chabane A., Chabardes S., Chabolle F., Chaix R., Champeaux Depond C., Chan Seng E., Chaussemy D., Chauvet D., Chaynes P., Chays A., Chazal J., Chibbaro S., Chirossel J.P., Chivoret N., Choukri M., Civit T., Clemenceau S., Coca H.A., Cochereau J., Coll G., Colnat Coulbois S., Compaore P., Cornelius J., Cornu P., Costache D., Coste A., Coubes P., Crampette L., Cristini A., Cuny E., Curey S., Czorny A., D’acunzi G., D’hardemare V., D’houtaud S., Dagain A., Dam Hieu P., Dandine J.B., Darie I., Darrouzet V., Dauta A., Dautheribes M., David P., De Germay B., De Rose F., De Saint-Denis T., Debaux J.B., Debono B., Debry C., Decouvelaere A., Decq P., Delalande O., Delestret I., Delhaye M., Delion M., Delmas J. M., Delmotte A., Delpy P., Delsanti C., Derlon J.M., Derrey S., Desenclos C., Desgeorges M., Desplat A., Desse N., Dessi P., Destandau J., Destrieux C., Devaux B., Dezamis E., Dhellemmes P., Di Tommaso L., Diabira S., Diaz A., Dimitriu C., Djedid R., Djindjian M., Do L., Doe K., Dorel Le-The M., Dorfmuller G., Dorwling-Carter D., Dran G., Dubois G., Dudoit T., Duffau H., Dufour H., Dufour T., Duhem R., Dulou R., Dumas B., Duntze J., Dupard T., Dupuy M., Durand A., Dussartre X., Dutertre G., Duthel R., Eap C., El Fertit H., Elouahdani-Hamdi S., Emery E., Engelhardt J., Espagno C., Esposito P., Faguer R., Faillot T., Farah W., Faure A., Faure P., Ferrand Sorbets S., Fesselet J., Fichten A., Fischer D., Fischer Lokou D., Fontaine D., Fotso M.J., Fournier D., Fowo-Ngadjou S., Francois P., Frank B., Frappaz D., Freger P., Freitas Olim E., Freppel S., Froelich S., Fuentes J.-M., Fuentes S., Gaberel T., Gadan R., Gaillard S., Ganem F., Gantois C., Gauchez P., Gay M., George B., Giacomelli R., Gigaud M., Gil Robles S., Gimbert E., Ginguene C., Goasguen O., Godard J., Godfrin G., Gomez A., Gonzalez Martinez V., Gosset P., Gouello G., Goutagny S., Graillon T., Gras Combe G., Grassi M., Grayeli B., Grelat M., Grellier P., Grisoli F., Guarnieri J., Guedon, Guegan Y., Guenot M., Guerra Sierra D., Gueye E.M, Gurshi M., Guyotat J., Haddad E., Haegelen C., Hamdi S., Hamel O., Hamlat A., Hannequin P., Hansen Von Bunau F., Hatem O., Hayek G., Herbrecht A., Herman P., Hladky J.P., Hoarau X., Hoffmann D., Horodyckid C., Huot J.C., Iakovlev G., Ibrahim R., Irthum B., Ischac R., Jacquesson T., Jacquet G., James S., Jan M., Jarraya B., Jecko V., Jouanneau E., Joud A., Julhien T., Kaddoum H., Kalamarides M., Karachi C., Katrangi H., Kaya J.M., Kehrli P., Keravel Y., Khalfallah M., Khalil I., Khalil T., Khouri K., Khouri S., Kleiber J.C., Klein O., Koudsie A., Krichen W., Kuzeawu A., Laborde G., Laccoureye L., Lagarrigue J., Laguerre D., Lahiani M., Lahlou M.A., Langlois O., Lapierre F., Lapras C., Lascu, Launay O., Lavieille J.P., Le Corre M., Le Fay, Le Franc M., Le Guerinel C., Lefevre P., Legars D., Lejeune J.P., Lemaire J.J., Lena G., Lepeintre J.F., Leriche B., Leroy H.A., Lescure J.P., Leston J.M., Leveque M., Liguoro D., Lioret E., Listrat A., Litre F., Litrico S., Loiseau H., Lonjon M., Lonjon N., Lopes M., Loret J.E., Lot G., Louis E., Louveau A., Lubrano V., Lucas F., Lucas O., Lungu G., M. Dorel Le-The, Maarrawi J., Magheru C., Magro E., Maheut-Lourmiere J., Mahla K., Maillard A., Maingot M., Maisonneuve, Maitrot D., Makiese O., Mandat S., Mandonnet E., Manet R., Mansour M., Manzo N., Marchal J.C., Marie J.P., Marinho P., Marnet D., Marniche A., Martin C., Martin S., Melot A., Memia Zolo D., Mendes Martins V., Menegalli D., Menei P., Mercier P., Merlot I., Mertens P., Messerer M., Metellus P., Meyer-Bisch V., Meyer M., Mineo J.F., Mireau E., Mollier O., Monteil P., Montessuy R., Mora A., Morandi X., Morar S., Moraru C., Moreau J.J., Morel, Morel C., Mortada J., Mostofi K., Mottolese C., Moubarak K., Mourier L., Moyse E., Muckensturm B., Nader E., Nahas F., Namaki H., Narantuya K., Nataf F., Navarro S., Nebab, Nguyen J.P., Njee T., Nogues L., Noudel R., Nouet A., Nseir R., Nuti C., Orabi M., Orenstein D., Ouammou Y., Ouerchefani N., Page P., Palfi S., Pallud J., Palombi O., Paquis P., Paradot Mouton G., Parker F., Passagia J.G., Paternoster G., Pech Gourg G., Pelissou-Guyotat I., Peltier J., Pencalet P., Pencalet Ph., Penchet G., Peragut J.C., Perez A., Pernot P., Perrin G., Person H., Peruzzi P., Petit A., Petit D., Peyre M., Pimenta N.J.G., Pinelli C., Piot B., Plas B., Plas J.Y., Polo G., Popa C., Popa C.P., Porhiel V., Postelnicu A., Pouit B., Pr Vincent, Privat J.M., Proust F., Pruvot-Occean A.S., Puget S., Rabehenoina C., Rabhi M., Ragragui O., Rambolarimanana T., Ranchere, Raoul S., Rasendrarijao D., Rech F., Redondo A., Regis J., Reina V., Remond, Remond J., Reynier Y., Reyns N., Ricci Franchi A.C., Richet, Richet A., Ricouart F., Riegel T., Riem T., Riffaud L., Rigoard P., Robert G., Robert R., Robier A., Roche P.H., Rodriguez M.-A., Rodriguez V., Ros M., Roualdes G., Roualdes V., Rougier A., Roujeau T., Rousseaux P., Roux F., Roux F.X., Rue M., Sabatier J., Sabatier P., Sabbah M., Sacko O., Sainte-Rose C., Sakka L., Salaud C., Salle H., Salmon B., San Galli F., Sankaredja J.M., Sautreaux J.L., Sauvaget, Sauvaget F., Scarone P., Scavarda D., Scherpereel B., Schmidt E., Segnarbieux F., Seigneuret E., Seizeur R., Selek L., Sichez J.P., Sid Hamed S., Signorelli F., Silhouette B., Simon A., Simon E., Simonneau A., Sinardet D., Sindou M., Sleiman M., Sol J.C., Soumare O., Srour A., Srour R., Staquet H., Stecken J., Stella I., Sterkers O., Stilhart B., Szathmari A., Taha S., Tazi S., Ternier J., Testa O., Tetard M.C., Theret E., Thiebaut J.B., Thines L., Thomas C., Thomassin J.M., Tigan L., Timofeev A., Tobenas Dujardin A.C., Todeschi J., Tonnelle V., Tourneux H., Toussaint P., Touta A., Tran Ba Huy P., Travers N., Tremoulet M., Turak B., Vallee B., Vally P., Van Effenterre R., Van Raay Y., Vaneecloo F.M., Vassal F., Vassal M., Velut S., Vidal J., Vignes J.R., Villette L., Vincentelli A.F., Vinchon M., Vinikoff L., Voirin J., Wager M., Yordanova Y., Zaïri F., Zemmoura I., Zerah M., Ziyadeh J.
Pathologists:
Adam C., Adle-Biassette H., Alemany P., Algros M.P., Amat C., Andraud M., Andreiuolo F., Ansart F., Arbez-Gindre F., Arbion F., Arrivets P., Attencourt C., Aubert S., Aubriot Lorton M.H., Averous G., Aziza J., Baglin A.C., Baldet P., Bar X., Baras V., Barbey C., Bay A., Bazille C., Bedgedjian I., Bedossa P., Benabidallah S., Benali A., Bergemer Fouquet A. M., Bergouignan M.A., Bernard-Decot C., Bernier M., Bertocchi C., Beuvon F., Bielle F., Billotet C., Birembaut P., Bisiau S., Blechet C., Bondoin L., Bonneau C., Bonyhay G., Bordier X., Boudjadi S., Boulagnon-Rombi C., Boutonnat J., Bouvier C., Brambilla E., Branquet D., Breibach F., Bressenot A., Broche C., Brouchet A., Brouland J.P., Brousset P., Cabrol C., Cahn V., Calvet P., Camo J., Camparo P., Capuani C., Cassagnau E., Casse Jm., Cathelineau D., Caulet S., Caveriviere P., Cazals-Hatem D., Chambonniere M.L., Chapon F., Charlotte F., Chatelain D., Chenard M.P., Chevalier X., Chiforeanu D.C., Chretien F., Christov C., Clairotte A., Cohen C., Conan-Charlet V., Concha X., Cordonnier C., Cormier B., Costa K., Costa S., Costes-Charlet N., Costes V., Coulon A., Couvelard A., Croue A., Cruel T., Dag X., Danjoux M., Darrasse D., Daumas-Duport C., Del M., Delage Corre M., Delalande F., Delfour C., Delfour Ch., Delisle M.B., Delsol M., Denis-Musquer M., Deschamps L., Desestret V., Desrousseaux M., Diebold M.D., Donsbeck A.V., Dreux N., Droy-Dupre L, Dubost G., Duchesne M., Ducoin H., Dudez O., Duga I., Dumollard J.M., Durand L., Dusorbier C., Dusserre L., Duval H., Eimer S., Alami-Thomas W., Elouaret Y., Escourrou G., Etchandy C., Eyremandi R.P., Fabrice P., Fallet-Bianco C., Faroy Menciere B., Felce Dachez M., Felix S., Fernandez C., Fetissof F., Feutry C., Figarella-Branger D., Fleury C., Fontaine A., Forest F., Fornes P., Fouet B., Fregeville M., Fromont G., Gaspard C., Gauchotte G., Gay G., Godfraind C., Gontier M.F., Gonzalez S., Goujon J.M., Gray F., Gros P., Guillou P.J., Guiry C., Harimenshi J. M., Heitzmann A., Henin D., Hennequin V., Heymann M.F., Ikoli J.F., Istier L., Jazeron J.F., Jeantet M., Jouvet A., Kandel-Aznar C., Kantelip B., Kemeny J.L., Kerdraon O., Kerdraon R., Kermanac H P., Kermanac H P., Khaddage A., Kleinclaus I., Krzisch S., Kujas M., L.E., Labrousse F., Lacroix C., Lamant. L, Lantuejoul S., Laquerriere A., Laurent-Yriarte M.C., Laurent C., Le Gall F., Le Houcq M., Le Naoures-Meal C., Lechapt E., Leclair F., Leclercq, Lecointre C., Leger F., Lepreux S., Lerintiu F., Levillain P., Lhermitte B., Liprandi A., Llamas F., Llinares K., Longchampt E., Loussouarn D., Machet M.C., Maitre F., Majek-Zakine E., Manent A.M., Maran A., Marcellin L., Marchal A., Marcon N., Marcorelles P., Mareel A., Marguet C., Marie B., Martin L., Gallo M., Maues De Paula A., Maurage C.A., Mazerolles C., Mensah A., Mergey E., Meyronet D., Michalak S., Michels J.M., Michenet P., Michiels J.F., Mihlai Marcela I., Milin S., Miquel C., Mohr M., Mokhtari K., Mondon C., Monegier Du Sorbier C., Morand Dusserre I., Moreau A., Moreau M., Mos, Mosnier J.F., Musso Rigal C., Myrmel K.S., N Guyen A., Neuville A., Oksman A., Onea M.A., Pages M., Palasse J., Patey M., Pellissier J.F., Peoc’h M., Petrella T., Philippe A., Pialat J., Pluot M., Polivka M., Pommepuy I., Pradere M., Projetti F., Quintana M., Quintin I., Quintyn-Ranty M.L., Ramos J., Ranfaing E., Raoux D., Raynaud P., Reis Borges R., Renaud F., Renjard L., Reyre J., Richard P., Richard S., Rigau V., Ringenbach F., Riviere B., Roger P., Rouquette I., Rousseau A., Rousselet M.C., Rousselot C., Sabourin J.C., Saguet V., Saïkali S., Saint-Paul M.C., Saint Pierre G., Salon C., Sam, Samaison, Samaison L., Savin C., Selves J., Seurat P., Sevestre H., Singeorzan C., Sorbara R., Soulard R., Souraud J.B., Straub P., Streichenberger N., Sturm N., Szablewski V., Talagas M., Taris, Taris M., Tauziede-Espariat A., Thi N., Toquet C., Tortel M.C., Toubeau G., Tournier E., Uro-Coste E., Valmary Degano S., Vandenbos F., Varlet P., Vasiljevic A., Veresezan L., Verhulst P., Viennet G., Vignaud J.M., Vigouroux C., Villa C., Vital A., Warter A., Wassef M., Weinbreck N., Yacoub M., Zachar D., Zidane Marinnes M.
Funding
This work was conducted with the financial support of grants from the National French Institute of Cancer (INCa), la Ligue Nationale Contre le Cancer, the Committee 34, l’Association pour la Recherche sur les Tumeurs Cérébrales (ARTC et ARTC Sud), l’ANOCEF, la SFNC, le Rotary Club (AGLY), le Département de l’Hérault, and le Groupe de Neuro-oncologie du Languedoc Roussillon.
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Depond, C.C., Zouaoui, S., Darlix, A. et al. Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015. Acta Neurochir 166, 214 (2024). https://doi.org/10.1007/s00701-024-06093-z
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DOI: https://doi.org/10.1007/s00701-024-06093-z