Abstract
Background
Patients presenting with large brain metastases (LBM) pose a management challenge to the multidisciplinary neuro-oncologic team. Treatment options include surgery, whole-brain or large-field radiation therapy (WBRT), stereotactic radiosurgery (SRS), or a combination of these.
Objective
To determine if corticosteroid therapy followed by SRS allows for efficient minimally invasive care in patients with LBMs not compromised by mass effect.
Methods
We analyzed the change in tumor volume to determine the efficacy of single-session SRS in the treatment of LBM in comparison to other treatment modalities. Twenty-nine patients with systemic cancer and brain metastasis (≥ 2.7 cm in greatest diameter) who underwent single-session SRS were included.
Results
Among 29 patients, 69% of patients had either lung, melanoma, or breast cancer. The median initial tumor size (maximal diameter) was 32 mm (range 28–43), and the median initial tumor volume was 9.56 cm3 (range 1.56–25.31). The median margin dose was 16 Gy (range 12–18). The average percent decrease in tumor volume compared to pre-SRS volume was 55% on imaging at 1–2 months, 58% at 3–5 months, 64% at 6–8 months, and 57% at > 8 months. There were no adverse events immediately following SRS. Median corticosteroid use after SRS was 21 days. Median survival after radiosurgery was 15 months.
Conclusion
Initial high-dose corticosteroid therapy followed by prompt single-stage SRS is a safe and efficacious method to manage patients with LBMs (defined as ≥ 2.7 cm).
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Portions of this work were presented in a poster presentation at the AANS in San Diego in April 2019, a poster presentation at the SNO meeting in NY in August 2019, and as an oral presentation at the virtual IRRF meeting in June 2020.
Douglas Kondziolka is a senior author
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Benjamin, C., Gurewitz, J., Nakamura, A. et al. Up-front single-session radiosurgery for large brain metastases—volumetric responses and outcomes. Acta Neurochir 165, 1365–1378 (2023). https://doi.org/10.1007/s00701-023-05491-z
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DOI: https://doi.org/10.1007/s00701-023-05491-z