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ABO blood group in aneurysmal subarachnoid haemorrhage—a pilot study

  • Original Article -Vascular Neurosurgery - Aneurysm
  • Published:
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Abstract

Purpose

To evaluate the distribution and impact of ABO blood group on the baseline characteristics and clinical outcomes of patients presenting with aneurysmal subarachnoid haemorrhage (aSAH).

Methods

Retrospective, single-centre study of patients admitted to a neurosurgical department in the UK, with a diagnosis of spontaneous subarachnoid haemorrhage between May 2014 and January 2020. Patients were categorised by ABO blood type and by Rhesus status. Clinical outcomes such as initial bleeding, rebleeding, delayed cerebral ischaemia (DIND) and venous thromboembolism were analysed in relation to the size of their association with ABO blood type. Hospital mortality rate, Glasgow Outcome Score (GOS) — at discharge and 3 months post-ictus, requirement for ventriculoperitoneal shunt insertion, discharge destination and inpatient length of stay were also considered.

Results

Four-hundred twelve adult patients admitted with aSAH were included in our analysis. The distribution of ABO group or Rhesus status in our cohort did not differ significantly from the general population in the UK. Blood group A patients had a significantly increased risk of developing DIND, compared with non-blood group A patients (OR, 1.88 [95% CI: 1.10–3.21]).

Conclusions

ABO blood type appears to influence aSAH sequelae. Blood group A patients are at highest risk of DIND following aSAH.

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References

  1. Ando T, Sakai N, Yamada H, Iwai T, Nishimura Y, Hirata T, Funakoshi T, Takada M (1989) Analysis of reruptured cerebral aneurysms and the prophylactic effects of barbiturate therapy on the early stage. Neurol Res 11:245–248. https://doi.org/10.1080/01616412.1989.11739900

    Article  CAS  PubMed  Google Scholar 

  2. Bir SC, Bollam P, Nanda A (2015) Distribution of ABO blood groups in the patients with intracranial aneurysm and association of different risk factors with particular blood type. Asian J Neurosurg 10:153–157. https://doi.org/10.4103/1793-5482.161188

    Article  PubMed  PubMed Central  Google Scholar 

  3. Dentali F, Sironi AP, Ageno W, Bonfanti C, Crestani S, Frattini F, Steidl L, Franchini M (2013) Relationship between ABO blood group and hemorrhage: a systematic literature review and meta-analysis. Semin Thromb Hemost 39:72–82. https://doi.org/10.1055/s-0032-1329550

    Article  PubMed  Google Scholar 

  4. Dentali F, Sironi AP, Ageno W, Turato S, Bonfanti C, Frattini F, Crestani S, Franchini M (2012) Non-O blood type is the commonest genetic risk factor for VTE: results from a meta-analysis of the literature. Semin Thromb Hemost 38:535–548. https://doi.org/10.1055/s-0032-1315758

    Article  PubMed  Google Scholar 

  5. Dubinski D, Won SY, Behmanesh B, Brawanski N, Geisen C, Seifert V, Senft C, Konczalla J (2018) The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma. PLoS ONE 13:e0204331. https://doi.org/10.1371/journal.pone.0204331

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Dubinski D, Won SY, Behmanesh B, Kashefiolasl S, Geisen C, Seifert V, Senft C, Konczalla J (2018) Influence of ABO blood type on the outcome after non-aneurysmal subarachnoid hemorrhage. Acta Neurochir (Wien) 160:761–766. https://doi.org/10.1007/s00701-018-3489-9

    Article  Google Scholar 

  7. Dubinski D, Won SY, Konczalla J, Mersmann J, Geisen C, Herrmann E, Seifert V, Senft C (2017) The role of ABO blood group in cerebral vasospasm, associated intracranial hemorrhage, and delayed cerebral ischemia in 470 patients with subarachnoid hemorrhage. World Neurosurg 97:532–537. https://doi.org/10.1016/j.wneu.2016.10.065

    Article  PubMed  Google Scholar 

  8. Eastlund T (1998) The histo-blood group ABO system and tissue transplantation. Transfusion 38:975–988. https://doi.org/10.1046/j.1537-2995.1998.381098440863.x

    Article  CAS  PubMed  Google Scholar 

  9. Franchini M, Lippi G (2016) Relative risks of thrombosis and bleeding in different ABO blood groups. Semin Thromb Hemost 42:112–117. https://doi.org/10.1055/s-0035-1564832

    Article  PubMed  Google Scholar 

  10. Fujii Y, Takeuchi S, Sasaki O, Minakawa T, Koike T, Tanaka R (1996) Ultra-early rebleeding in spontaneous subarachnoid hemorrhage. J Neurosurg 84:35–42. https://doi.org/10.3171/jns.1996.84.1.0035

    Article  CAS  PubMed  Google Scholar 

  11. Groot HE, Villegas Sierra LE, Said MA, Lipsic E, Karper JC, van der Harst P (2020) Genetically determined ABO blood group and its associations with health and disease. Arterioscler Thromb Vasc Biol 40:830–838. https://doi.org/10.1161/atvbaha.119.313658

    Article  CAS  PubMed  Google Scholar 

  12. Horwich L, Evans DA, McConnell RB, Donohoe WT (1966) ABO blood groups in gastric bleeding. Gut 7:680–685. https://doi.org/10.1136/gut.7.6.680

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Ingall T, Asplund K, Mähönen M, Bonita R (2000) A multinational comparison of subarachnoid hemorrhage epidemiology in the WHO MONICA stroke study. Stroke 31:1054–1061. https://doi.org/10.1161/01.str.31.5.1054

    Article  CAS  PubMed  Google Scholar 

  14. Jenkins PV, O’Donnell JS (2006) ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? Transfusion 46:1836–1844. https://doi.org/10.1111/j.1537-2995.2006.00975.x

    Article  CAS  PubMed  Google Scholar 

  15. Kshettry VR, Rosenbaum BP, Seicean A, Kelly ML, Schiltz NK, Weil RJ (2014) Incidence and risk factors associated with in-hospital venous thromboembolism after aneurysmal subarachnoid hemorrhage. J Clin Neurosci 21:282–286. https://doi.org/10.1016/j.jocn.2013.07.003

    Article  PubMed  Google Scholar 

  16. Larsen CC, Astrup J (2013) Rebleeding after aneurysmal subarachnoid hemorrhage: a literature review. World Neurosurg 79:307–312. https://doi.org/10.1016/j.wneu.2012.06.023

    Article  PubMed  Google Scholar 

  17. Moeller A, Weippert-Kretschmer M, Prinz H, Kretschmer V (2001) Influence of ABO blood groups on primary hemostasis. Transfusion 41:56–60. https://doi.org/10.1046/j.1537-2995.2001.41010056.x

    Article  CAS  PubMed  Google Scholar 

  18. Naidech AM, Janjua N, Kreiter KT, Ostapkovich ND, Fitzsimmons BF, Parra A, Commichau C, Connolly ES, Mayer SA (2005) Predictors and impact of aneurysm rebleeding after subarachnoid hemorrhage. Arch Neurol 62:410–416. https://doi.org/10.1001/archneur.62.3.410

    Article  PubMed  Google Scholar 

  19. Orstavik KH, Magnus P, Reisner H, Berg K, Graham JB, Nance W (1985) Factor VIII and factor IX in a twin population. Evidence for a major effect of ABO locus on factor VIII level. Am J Hum Genet 37:89–101

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Reddy VM, Daniel M, Bright E, Broad SR, Moir AA (2008) Is there an association between blood group O and epistaxis? J Laryngol Otol 122:366–368. https://doi.org/10.1017/s0022215107008560

    Article  CAS  PubMed  Google Scholar 

  21. Sayama CM, Liu JK, Couldwell WT (2006) Update on endovascular therapies for cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. Neurosurg Focus 21:E12. https://doi.org/10.3171/foc.2006.21.3.12

    Article  PubMed  Google Scholar 

  22. Song J, Chen F, Campos M, Bolgiano D, Houck K, Chambless LE, Wu KK, Folsom AR, Couper D, Boerwinkle E, Dong JF (2015) Quantitative influence of ABO blood groups on factor VIII and its ratio to von Willebrand factor, novel observations from an ARIC study of 11,673 subjects. PLoS ONE 10:e0132626. https://doi.org/10.1371/journal.pone.0132626

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Starke RM, Chalouhi N, Ali MS, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, Koch WJ, Dumont AS (2013) The role of oxidative stress in cerebral aneurysm formation and rupture. Curr Neurovasc Res 10:247–255. https://doi.org/10.2174/15672026113109990003

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Starke RM, Connolly ES Jr (2011) Rebleeding after aneurysmal subarachnoid hemorrhage. Neurocrit Care 15:241–246. https://doi.org/10.1007/s12028-011-9581-0

    Article  CAS  PubMed  Google Scholar 

  25. Storry JR, Olsson ML (2009) The ABO blood group system revisited: a review and update. Immunohematology 25:48–59

    Article  CAS  Google Scholar 

  26. Takayama W, Endo A, Koguchi H, Sugimoto M, Murata K, Otomo Y (2018) The impact of blood type O on mortality of severe trauma patients: a retrospective observational study. Crit Care 22:100. https://doi.org/10.1186/s13054-018-2022-0

    Article  PubMed  PubMed Central  Google Scholar 

  27. Transport NHSBa (2020) Blood types. https://www.blood.co.uk/why-give-blood/blood-types/. Accessed 07–01–2020

  28. Unda SR, Vats T, Garza R, Cezaryirli P, Altschul DJ (2020) Role of ABO blood type in delayed cerebral ischemia onset and clinical outcomes after aneurysmal subarachnoid hemorrhage in an ethnic minority urban population. Surg Neurol Int 11:108. https://doi.org/10.25259/sni_10_2020

    Article  PubMed  PubMed Central  Google Scholar 

  29. van der Steen WE, Leemans EL, van den Berg R, Roos Y, Marquering HA, Verbaan D, Majoie C (2019) Radiological scales predicting delayed cerebral ischemia in subarachnoid hemorrhage: systematic review and meta-analysis. Neuroradiology 61:247–256. https://doi.org/10.1007/s00234-019-02161-9

    Article  PubMed  Google Scholar 

  30. Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, Mendelow AD, Juvela S, Yonas H, Terbrugge KG, Macdonald RL, Diringer MN, Broderick JP, Dreier JP, Roos YB (2010) Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke 41:2391–2395. https://doi.org/10.1161/strokeaha.110.589275

    Article  PubMed  Google Scholar 

  31. Zhou S, Welsby I (2014) Is ABO blood group truly a risk factor for thrombosis and adverse outcomes? World J Cardiol 6:985–992. https://doi.org/10.4330/wjc.v6.i9.985

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, The General Infirmary at Leeds, Leeds, LS1 3EX, UK

    Oliver Richards, Christopher Akhunbay-Fudge, Neeraj Kalra, Paul Chumas & Ian A. Anderson

  2. Leeds Institute for Data Analytics, School of Medicine, University of Leeds, Leeds, UK

    Kirsten J. Cromie & Richard G. Feltbower

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  1. Oliver Richards
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Correspondence to Paul Chumas.

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This article is part of the Topical Collection on Vascular Neurosurgery—Aneurysm

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Richards, O., Cromie, K.J., Akhunbay-Fudge, C. et al. ABO blood group in aneurysmal subarachnoid haemorrhage—a pilot study. Acta Neurochir 164, 507–515 (2022). https://doi.org/10.1007/s00701-021-05079-5

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  • DOI: https://doi.org/10.1007/s00701-021-05079-5

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