Abstract
A recent tasked-based fMRI study unveiled a network of areas implicated in the process of visuo-proprioceptive integration of the right hand. In this study, we report a case of a patient operated on in awake conditions for a glioblastoma of the left superior parietal lobule. When stimulating a white matter site in the anterior wall of the cavity, the patient spontaneously reported a discrepancy between the visual and proprioceptive perceptions of her right hand. Using several multimodal approaches (axono-cortical evoked potentials, tractography, resting-state functional connectivity), we demonstrated converging support for the hypothesis that tumor-induced plasticity redistributed the left-lateralized network of right-hand visuo-proprioceptive integration towards its right-lateralized homolog.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Balestrini S, Francione S, Mai R, Castana L, Casaceli G, Marino D, Provinciali L, Cardinale F, Tassi L (2015) Multimodal responses induced by cortical stimulation of the parietal lobe: a stereo-electroencephalography study. Brain 138(Pt 9):2596–2607
Corrivetti F, de Schotten MT, Poisson I, Froelich S, Descoteaux M, Rheault F, Mandonnet E (2019) Dissociating motor-speech from lexico-semantic systems in the left frontal lobe: insight from a series of 17 awake intraoperative mappings in glioma patients. Brain Struct Funct 224(3):1151–1165
Descoteaux M, Angelino E, Fitzgibbons S, Deriche R (2007) Regularized, fast, and robust analytical Q-ball imaging. Magn Reson Med 58(3):497–510
Descoteaux M, Deriche R, Knösche TR, Anwander A (2009) Deterministic and probabilistic tractography based on complex fibre orientation distributions. IEEE Trans Med Imaging 28(2):269–286
Downing PE, Jiang Y, Shuman M, Kanwisher N (2001) A cortical area selective for visual processing of the human body. Science 293(5539):2470–2473
Gonen T, Gazit T, Korn A, Kirschner A, Perry D, Hendler T, Ram Z (2017) Intra-operative multi-site stimulation: expanding methodology for cortical brain mapping of language functions. PLoS One. https://doi.org/10.1371/journal.pone.0180740
Herbet G, Lemaitre A-L, Moritz-Gasser S, Cochereau J, Duffau H (2019) The antero-dorsal precuneal cortex supports specific aspects of bodily awareness. Brain 142(8):2207–2214
Limanowski J, Blankenburg F (2016) Integration of visual and proprioceptive limb position information in human posterior parietal, premotor, and extrastriate cortex. J Neurosci 36(9):2582–2589
Mandonnet E (2019) Transopercular resection of IDH-mutated insular glioma: a critical appraisal of an initial experience. World Neurosurg. https://doi.org/10.1016/j.wneu.2019.08.071
Mandonnet E, Winkler PA, Duffau H (2010) Direct electrical stimulation as an input gate into brain functional networks: principles, advantages and limitations. Acta Neurochir 152(2):185–193
Mandonnet E, De Witt HP, Poisson I et al (2015) Initial experience using awake surgery for glioma: oncological, functional, and employment outcomes in a consecutive series of 25 cases. Neurosurgery 76(4):382–389 discussion 389
Russell SM, Elliott R, Forshaw D, Kelly PJ, Golfinos JG (2005) Resection of parietal lobe gliomas: incidence and evolution of neurological deficits in 28 consecutive patients correlated to the location and morphological characteristics of the tumor. J Neurosurg 103(6):1010–1017
Sanai N, Martino J, Berger MS (2012) Morbidity profile following aggressive resection of parietal lobe gliomas. J Neurosurg 116(6):1182–1186
Schwoebel J, Coslett HB (2005) Evidence for multiple, distinct representations of the human body. J Cogn Neurosci 17(4):543–553
Tournier J-D, Calamante F, Connelly A (2007) Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. Neuroimage 35(4):1459–1472
Tournier J-D, Calamante F, Connelly A (2012) MRtrix: diffusion tractography in crossing fiber regions. Int J Imaging Syst Technol 22(1):53–66
Van Beers RJ, Wolpert DM, Haggard P (2002) When feeling is more important than seeing in sensorimotor adaptation. Curr Biol 12(10):834–837
Vincent M, Guiraud D, Duffau H, Mandonnet E, Bonnetblanc F (2017) Electrophysiological brain mapping: basics of recording evoked potentials induced by electrical stimulation and its physiological spreading in the human brain. Clin Neurophysiol 128(10):1886–1890
Wolpert DM, Goodbody SJ, Husain M (1998) Maintaining internal representations: the role of the human superior parietal lobe. Nat Neurosci 1(6):529–533
Funding
MD was supported by the CRC-chirurgie 2016 from AP-HP. EM was supported by INSERM, contract interface 2018.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Patient gave full informed consent to participate to this study, which was approved by the ethics committee of Saint-Louis hospital (reference 2013/51).
Patient consent
The patient has consented to the submission of the case report for submission to the journal. This case report has been written in accordance with COPE guidelines and comply with the CARE statement.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on Functional Neurosurgery - Other
Rights and permissions
About this article
Cite this article
Mandonnet, E., Margulies, D., Stengel, C. et al. “I do not feel my hand where I see it”: causal mapping of visuo-proprioceptive integration network in a surgical glioma patient. Acta Neurochir 162, 1949–1955 (2020). https://doi.org/10.1007/s00701-020-04399-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00701-020-04399-2