Associations of histological and molecular alterations with invasion of the corpus callosum in gliomas

Abstract

Background

Glioma invading the corpus callosum (CC) accounts for approximately 14% of gliomas and is thought to be more aggressive. However, there is still a lack of studies on the pathogenesis and molecular features of this condition. Here, we examined the occurrence association of CC invasion with respect to patients’ clinical, pathological, and genetic characteristics.

Methods

First, a cohort of 331 patients was included, with 86 cases (26%) that were diagnosed with invasion glioma. They were all analyzed for basic clinical and pathological characteristics and four routinely tested glioma molecular markers. Second, 29 pairs of patients who underwent deep sequencing of 68 glioma molecular alterations were selected from both groups for in-depth analysis.

Results

The results of the first part showed that there was no difference between the two groups in terms of the basic factors in univariate analysis, while in multivariate logistic analysis, WHO grade was the risk factor for CC invasion (p = 0.001). The results of the second part showed that the paired groups had different genetic expression profiles, which highlighted glioma invading the CC as a distinct biological entity. PDGFRA mutation (PDGFRAmut) was present in 9 patients with invasive gliomas (31%), but only in one case (3.4%) in the control group (OR 17.331; 95% CI 1.987–151.156).

Conclusion

Our data revealed the clinical, pathological, and genetic characteristics of glioma invading the CC and showed that it may be associated with glioma WHO grade and PDGFRAmut, but not other factors. Thus, the risk signaling pathway may offer potential therapeutic targets for this disease.

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Acknowledgments

We thank Genetron Health who provided the next-generation sequencing platform, and we appreciate the technique of bioinformatic analysis provided by Liwen Jiang and Lan Su.

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Correspondence to Xinguang Yu.

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Shaoping Shen and Shiyu Feng are co-first author.

This article is part of the Topical Collection on Tumor – Glioma.

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Shen, S., Feng, S., Liu, H. et al. Associations of histological and molecular alterations with invasion of the corpus callosum in gliomas. Acta Neurochir 162, 1691–1699 (2020). https://doi.org/10.1007/s00701-020-04376-9

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Keywords

  • Corpus callosum
  • Glioma
  • Glioma molecular alterations
  • Butterfly Gliomas
  • Genetic characteristics
  • PDGFRA