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Surgical management of collision-tumors between vestibular schwannoma and meningioma in the cerebellopontine angle in patients with neurofibromatosis type 2

  • Original Article - Tumor - Schwannoma
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Abstract

Introduction

When vestibular schwannoma (VS) collides with meningioma at the cerebellopontine angle (CPA), a particular threat occurs. Sudden acceleration of tumor growth and unpredictable involvement of cranial nerves results in a special environment that aggravates management. The goal of this study was to analyze the extent of resection, postoperative facial and cochlear function, surgical strategy, and survival rates in patients with neurofibromatosis type 2 (NF2) with meningioma–vestibular schwannoma (M-VS) collision tumors.

Methods

A total of 1284 VS, including 165 NF2 VS were operated at our department between January 2004 and May 2018. Out of these cases, a group of six NF2 patients with seven M-VS collision tumors was found following careful analysis of neuroradiological data and pathological and surgical reports. Patients were evaluated for extent of tumor resection and, furthermore, postoperative facial and hearing function.

Results

Six patients with NF2 with seven M-VS collision tumors were included in this study. Mean age was 32 ± 8.2 years. A gross total resection (GTR) of both colliding tumors was achieved in only one case, a GTR of the meningioma and a subtotal resection (STR) of the VS in four cases and in two cases only, the meningioma was removed. In five of the cases, facial function was intact or good (House and Brackmann grades I–II) at long-term follow-up (mean follow-up 22 months). No mortality occurred during follow-up.

Conclusions

Collision between M and VS at the CPA is a particular phenomenon in NF2 patients that may aggravate the situation with less favorable surgical outcome than NF-2 VS without meningioma.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Tuebingen, Hoppe-Seyler-Straße 3, 72076, Tuebingen, Germany

    Sasan Darius Adib & M. Tatagiba

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  1. Sasan Darius Adib
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  2. M. Tatagiba
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Correspondence to Sasan Darius Adib.

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The authors declare that they have no conflict of interest.

Ethical approval

This study was performed in accordance with the ethical standards of the institutional research committee (University of Tuebingen/Ethic Commission) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent was obtained from all individual participants included in the study.

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This article is part of the Topical Collection on Tumor – Schwannoma

Details of previous presentations of portions of this research:

1. Previous presentation:

Name of the annual meeting: The 5th Symposium of World Federation of Neurosurgical Societies

Sponsoring society: no sponsoring society

Date: 17–22 April 2016

Location: Teheran, Iran

Presentation type: oral presentation

2. Previous presentation:

Name of the annual meeting: 67th Annual Meeting of the German Society of Neurosurgery

Sponsoring society: no sponsoring society

Date: 12–15 June 2016

Location: Frankfurt, Germany

Presentation type: oral presentation

3. Previous presentation:

Name of the annual meeting: EANS 2017 Annual Meeting

Sponsoring society: no sponsoring society

Date: 1–5 October 2017

Location: Venice, Italy

Presentation type: oral presentation

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Adib, S.D., Tatagiba, M. Surgical management of collision-tumors between vestibular schwannoma and meningioma in the cerebellopontine angle in patients with neurofibromatosis type 2. Acta Neurochir 161, 1157–1163 (2019). https://doi.org/10.1007/s00701-019-03933-1

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  • DOI: https://doi.org/10.1007/s00701-019-03933-1

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