Abstract
Clear cell meningiomas (CCMs) are rare subtypes of meningiomas and usually treated by maximum safely achievable tumor resection. We here present three hereditary cases with CCMs which were confirmed by Sanger sequencing of lymphocyte DNA. Gross total resection was achieved in a 5-year-old son with a spinal CCM and a 34-year-old father with a CCM in the cerebellopontine angle (CPA). For a 14-year-old daughter with CCM in the CPA, total resection was not achieved due to its large size. Early detection by screening high-risk family with CCM is strongly recommended.
Similar content being viewed by others
References
Chen H, Li XM, Chen YC, Wu JS, Dou YF, Wang Y, Xu J, Zhong P, Jiang CC, Wang XQ (2011) Intracranial clear cell meningioma: a clinicopathologic study of 15 cases. Acta Neurochir 153:1769–1780
Gerkes EH, Fock JM, den Dunnen WF, van Belzen MJ, van der Lans CA, Hoving EW, Fakkert IE, Smith MJ, Evans DG, Olderode-Berends MJ (2016) A heritable form of SMARCE1-related meningiomas with important implications for follow-up and family screening. Neurogenetics 17:83–89
Heth JA, Kirby P, Menezes AH (2000) Intraspinal familial clear cell meningioma in a mother and child. Case report. J Neurosurg 93:317–321
Ichinose T, Goto T, Ishibashi K, Takami T, Ohata K (2010) The role of radical microsurgical resection in multimodal treatment for skull base meningioma. J Neurosurg 113:1072–1078
Ko JK, Choi BK, Cho WH, Choi CH (2011) Non-dura based intraspinal clear cell meningioma. J Korean Neurosurg Soc 49:71–74
Kotecha RS, Pascoe EM, Rushing EJ, Rorke-Adams LB, Zwerdling T, Gao X, Li X, Greene S, Amirjamshidi A, Kim SK, Lima MA, Hung PC, Lakhdar F, Mehta N, Liu Y, Devi BI, Sudhir BJ, Lund-Johansen M, Gjerris F, Cole CH, Gottardo NG (2011) Meningiomas in children and adolescents: a meta-analysis of individual patient data. Lancet Oncol 12:1229–1239
Li H, Zhao M, Jiao Y, Li Z, Ma J, Wang S, Cao Y, Zhao J (2017) Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review. Childs Nerv Syst 33:239–248
Li Z, Zhang Y, Wang E, Wang Z, Li W, Huang S, Li J (2012) Intracranial clear cell meningioma in two children with blood relations: two case reports and literature review. Childs Nerv Syst 28:2143–2151
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Figarella-Branger D, Perry A, Reifenberger G, von Deimling A (2016) World Health Organization classification of tumors of the central nervous system. IARC, Lyon, pp 232–245
Ma L, Liu WK, Wang K, Shrestha B, Zhang YK (2009) Intracranial clear-cell meningioma. Acta Neurochir 151:373–378
Mazzoni A, Zanoletti E, Calabrese V (2012) Hearing preservation surgery in acoustic neuroma: long-term results. Acta Otorhinolaryngol Ital 32:98–102
Payano M, Kondo Y, Kashima K, Daa T, Yatsuka T, Kida H (2004) Two cases of nondura-based clear cell meningioma of the cauda equina. AP-MIS 112:141–147
Raffalli-Ebezant H, Rutherford SA, Stivaros S, Kelsey A, Smith M, Evans DG, Kilday JP (2015) Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case. Childs Nerv Syst 31:441–447
Rousseau A, Mokhtari K, Duyckaerts C (2008) The 2007 WHO classification of tumors of the central nervous system—what has changed? Curr Opin Neurol 21:720–727
Smith MJ, Ahn S, Lee JI, Bulman M, Plessis DD, Suh YL (2017) SMARCE1 mutation screening in classification of clear cell meningiomas. Histopathology 70:814–820
Smith MJ, O’Sullivan J, Bhaskar SS, Hadfield KD, Poke G, Caird J, Sharif S, Eccles D, Fitzpatrick D, Rawluk D, du Plessis D, Newman WG, Evans DG (2013) Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas. Nat Genet 45:295–298
Smith MJ, Wallace AJ, Bennett C, Hasselblatt M, Elert-Dobkowska E, Evans LT, Hickey WF, van Hoff J, Bauer D, Lee A, Hevner RF, Beetz C, du Plessis D, Kilday JP, Newman WG, Evans DG (2014) Germline SMARCE1 mutations predispose to both spinal and cranial clear cell meningiomas. J Pathol 234:436–440
Tauziede-Espariat A, Parfait B, Besnard A, Lacombe J, Pallud J, Tazi S, Puget S, Lot G, Terris B, Cohen J, Vidaud M, Figarella-Branger D, Monnien F, Polivka M, Adle-Biassette H, Varlet P (2017) Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis. Brain Pathol 5
Zorludemir S, Scheithauer BW, Hirose T, VanHouten C, Miller G, Meyer FB (1995) Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma. Am J Surg Pathol 19:493–505
Zanoletti E, Cazzador D, Faccioli C, Martini A, Mazzoni A (2014) Closure of the sigmoid sinus in lateral skull base surgery. Acta Otorhinolaryngol Ital 34:184–188
Acknowledgments
We thank Ms. Lori Radcliffe for her assistance with English language editing.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All procedures performed in this report involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from the patient in the report.
Additional information
This article is part of the Topical Collection on Brain Tumors
Rights and permissions
About this article
Cite this article
Inoue, T., Shitara, S., Ozeki, M. et al. Hereditary clear cell meningiomas in a single family: three-cases report. Acta Neurochir 160, 2321–2325 (2018). https://doi.org/10.1007/s00701-018-3727-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00701-018-3727-1