Abstract
We present a case report of a patient who presented with nausea and vomiting, as well as acromegalic features. Following testing, a pituitary adenoma and mediastinal non-Hodgkin’s lymphoma were diagnosed. Following two cycles of R-CHOP chemotherapy, imaging showed significant decrease in size of the sellar tumor. Following resection of tumor, both frozen and permanent section revealed only necrotic material. Further research into the potential utility of doxorubicin for the treatment of recurrent or refractory pituitary adenomas may be warranted.
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Attanasio R, Orlandi P, Dallabonzana D, Lodrini A, Ferrari M, Maccagnano E, Verde G, Cozzi R, Liuzzi A, Chiodini PG (1991) Doxorubicin for acromegaly: a case report. J Endocrinol Investig 14:493–497
Aydogan BI, Unluturk U, Emral R, Gullu S (2017) Course of aggressive somatotroph, corticotroph and mammotroph tumors under temozolomide; report of three cases and review of the literature. Turk Neurosurg. https://doi.org/10.5137/1019-5149.JTN.20216-17.1
Colao A, Ferone D, Marzullo P, Cappabianca P, Cirillo S, Boerlin V, Lancranjan I, Lombardi G (2001) Long-term effects of depot long-acting somatostatin analog octreotide on hormone levels and tumor mass in acromegaly. J Clin Endocrinol Metab 86:2779–2786. https://doi.org/10.1210/jcem.86.6.75564
Freda PU (2002) Somatostatin analogs in acromegaly. J Clin Enocrinol Metab 87:3013–3018. https://doi.org/10.1210/jcem.87.7.8665
Kasperlik-Zaluska AA, Wislawski J, Kaniewska J, Zborzil J, Frankiewicz E, Zgliczynski S (1987) Cytostatics for acromegaly. Marked improvement in a patient with an invasive pituitary tumour. Acta Endocrinol 116:347–349
Lancranjan I, Bruns C, Grass P, Jaquet P, Jervell J, Kendall-Taylor P, Lamberts SW, Marbach P, Orskov H, Pagani G, Sheppard M, Simionescu L (1996) Sandostatin LAR: a promising therapeutic tool in the management of acromegalic patients. Metabolism 45:67–71
Liu X, Ma S, Dai C, Cai F, Yao Y, Yang Y, Feng M, Deng K, Li G, Ma W, Xin B, Lian W, Xiang G, Zhang B, Wang R (2013) Antiproliferative, antiinvasive, and proapoptotic activity of folate receptor alpha-targeted liposomal doxorubicin in nonfunctional pituitary adenoma cells. Endocrinology 154:1414–1423
Ravindra VM, Raheja A, Corn H, Driscoll M, Welt C, Simmons DL, Couldwell WT (2017) Primary pituitary diffuse large B-cell lymphoma with somatotroph hyperplasia and acromegaly: case report. J Neurosurg 126:1725–1730
Roberts BK, Ouyang DL, Lad SP, Chang SD, GRt H, Adler JR Jr, Soltys SG, Gibbs IC, Remedios L, Katznelson L (2007) Efficacy and safety of CyberKnife radiosurgery for acromegaly. Pituitary 10:19–25
Tritos NA, Biller BM (2017) Pegvisomant: a growth hormone receptor antagonist used in the treatment of acromegaly. Pituitary 20:129–135
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Lekovic, G.P., Batra, A., Barnard, Z.R. et al. Growth hormone-secreting pituitary macroadenoma presenting concurrently with non-Hodgkin’s lymphoma and responding to doxorubicin treatment: case report and review of the literature. Acta Neurochir 160, 2363–2366 (2018). https://doi.org/10.1007/s00701-018-3714-6
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DOI: https://doi.org/10.1007/s00701-018-3714-6