Skip to main content

Tumor-to-tumor metastasis of lung adenocarcinoma into a spinal intradural solitary fibrous tumor: a case report

Acta Neurochirurgica volume 160, pages 2393–2396 (2018)Cite this article

Abstract

Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms commonly involving visceral or parietal pleura. We present the first report of tumor-to-tumor metastasis involving a pulmonary adenocarcinoma donor and an intradural SFT recipient. The patient presented with a 1 year history of diffuse back pain. A spinal intradural contrast-enhancing mass at the T9/10 level and a tumor of the lung were diagnosed radiologically. Bronchoscopic biopsy confirmed pulmonary adenocarcinoma in the right upper lung lobe. Due to deteriorating neurological status with conus medullaris syndrome, we performed a neurosurgical excision of the lesion. Histological analysis of the tumor revealed tumor-to-tumor metastasis of the adenocarcinoma to the SFT.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2
Fig. 3

Abbreviations

CD34:

Cluster of differentiation 34

CT:

Computed tomography

EMA:

Epithelial membrane antigen

MRI:

Multiple resonance imaging

SFT:

Solitary fibrous tumors

STAT6:

Signal transducer and activator of transcription 6

TTF-1:

Thyroid transcription factor-1

References

  1. Bansil R, Walia BS, Khan Z, Abrari A (2017) Metastasis to a spinal meningioma. Surg Neurol Int 8:102. https://doi.org/10.4103/sni.sni_466_16

    Article  PubMed  PubMed Central  Google Scholar 

  2. Brunnemann RB, Ro JY, Ordonez NG, Mooney J, El-Naggar AK, Ayala AG (1999) Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases. Mod Pathol 12:1034–1042

    CAS  PubMed  Google Scholar 

  3. Campbell LV Jr, Gilbert E, Chamberlain CR Jr, Watne AL (1968) Metastases of cancer to cancer. Cancer 22:635–643

    Article  Google Scholar 

  4. Chen HW, Dry SM, Seeger LL (2004) Primary lung carcinoma metastatic to a solitary fibrous tumor. Skelet Radiol 33:226–229. https://doi.org/10.1007/s00256-003-0676-3

    CAS  Article  Google Scholar 

  5. Das S, Chaudhary N, Ang LC, Megyesi JS (2017) Papillary thyroid carcinoma metastasizing to anaplastic meningioma: an unusual case of tumor-to-tumor metastasis. Brain Tumor Pathol 34:130–134. https://doi.org/10.1007/s10014-017-0289-5

    CAS  Article  PubMed  Google Scholar 

  6. de Saint Aubain Somerhausen N, Rubin BP, Fletcher CD (1999) Myxoid solitary fibrous tumor: a study of seven cases with emphasis on differential diagnosis. Mod Pathol 12:463–471

    PubMed  Google Scholar 

  7. Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL (2014) Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol 27:390–395. https://doi.org/10.1038/modpathol.2013.164

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. Fried BM (1930) Metastatic inoculation of a meningioma by cancer cells from a bronchiogenic carcinoma. Am J Pathol 6(47–52):41

    Google Scholar 

  9. Gonullu G, Sullu Y, Basoglu A, Elmali M, Karaoglanoglu M, Yucel I (2010) Metastatic breast carcinoma to solitary fibrous tumor in the lung. Indian J Cancer 47:76–78. https://doi.org/10.4103/0019-509X.58868

    CAS  Article  PubMed  Google Scholar 

  10. Hanau CA, Miettinen M (1995) Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 26:440–449

    CAS  Article  Google Scholar 

  11. Kragel C, Wei S (2011) Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report. J Med Case Rep 5:248. https://doi.org/10.1186/1752-1947-5-248

    Article  PubMed  PubMed Central  Google Scholar 

  12. Moody P, Murtagh K, Piduru S, Brem S, Murtagh R, Rojiani AM (2012) Tumor-to-tumor metastasis: pathology and neuroimaging considerations. Int J Clin Exp Pathol 5:367–373

    PubMed  PubMed Central  Google Scholar 

  13. Pamphlett R (1984) Carcinoma metastasis to meningioma. J Neurol Neurosurg Psychiatry 47:561–563

    CAS  Article  Google Scholar 

  14. Petraki C, Vaslamatzis M, Argyrakos T, Petraki K, Strataki M, Alexopoulos C, Sotsiou F (2003) Tumor to tumor metastasis: report of two cases and review of the literature. Int J Surg Pathol 11:127–135. https://doi.org/10.1177/106689690301100214

    Article  PubMed  Google Scholar 

  15. Sen SMS, McCulloch T (2010) Mesenteric solitary fibrous tumor containing metastasis from breast carcinoma: an unusual example of tumor-to-tumor metastasis. Diagn Histopathol 16:397–399

    Article  Google Scholar 

  16. Velez-Cubian FO, Gabordi RC, Smith PV, Toloza EM (2016) Tumor-to-tumor metastasis: an unusual case of breast cancer metastatic to a solitary fibrous tumor. J Thorac Dis 8:E374–E378. https://doi.org/10.21037/jtd.2016.03.79

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors would like to thank EDITAGE (www.editage.com) for editing the manuscript.

Author information

Affiliations

  1. Department of Neurosurgery, Winterthur Cantonal Hospital, Brauerstrasse 15, 8401, Winterthur, Switzerland

    Lazar Tosic, Dominik Baschera, Thomas Feuerstein & Alex Alfieri

  2. Department of Pathology, Winterthur Cantonal Hospital, Brauerstrasse 15, 8401, Winterthur, Switzerland

    Bastian Jentsch

  3. Brandenburg Medical School, Fehrbellinerstrasse 38, 16816, Neuruppin, Germany

    Alex Alfieri

Authors
  1. Lazar Tosic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dominik Baschera
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bastian Jentsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Thomas Feuerstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alex Alfieri
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lazar Tosic.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the participant included in the study.

Additional information

This article is part of the Topical Collection on Tumor-Other

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tosic, L., Baschera, D., Jentsch, B. et al. Tumor-to-tumor metastasis of lung adenocarcinoma into a spinal intradural solitary fibrous tumor: a case report. Acta Neurochir 160, 2393–2396 (2018). https://doi.org/10.1007/s00701-018-3700-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00701-018-3700-z

Keywords

  • Solitary fibrous tumor
  • Tumor to tumor metastasis
  • Pulmonary adenocarcinoma