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Acta Neurochirurgica

, Volume 160, Issue 7, pp 1385–1391 | Cite as

Transfer of obturator nerve for femoral nerve injury: an experiment study in rats

  • Depeng Meng
  • Jun Zhou
  • Yaofa Lin
  • Zheng Xie
  • Huihao Chen
  • Ronghua Yu
  • Haodong Lin
  • Chunlin Hou
Original Article - Peripheral Nerves
  • 89 Downloads

Abstract

Background

Quadriceps palsy is mainly caused by proximal lesions in the femoral nerve. The obturator nerve has been previously used to repair the femoral nerve, although only a few reports have described the procedure, and the outcomes have varied. In the present study, we aimed to confirm the feasibility and effectiveness of this treatment in a rodent model using the randomized control method.

Methods

Sixty Sprague–Dawley rats were randomized into two groups: the experimental group, wherein rats underwent femoral neurectomy and obturator nerve transfer to the femoral nerve motor branch; and the control group, wherein rats underwent femoral neurectomy without nerve transfer. Functional outcomes were measured using the BBB score, muscle mass, and histological assessment.

Results

At 12 and 16 weeks postoperatively, the rats in the experimental group exhibited recovery to a stronger stretch force of the knee and higher BBB score, as compared to the control group (p < 0.05). The muscle mass and myofiber cross-sectional area of the quadriceps were heavier and larger than those in the control group (p < 0.05). A regenerated nerve with myelinated and unmyelinated fibers was observed in the experimental group. No significant differences were observed between groups at 8 weeks postoperatively (p > 0.05).

Conclusions

Obturator nerve transfer for repairing femoral nerve injury was feasible and effective in a rat model, and can hence be considered as an option for the treatment of femoral nerve injury.

Keywords

Nerve transfer Quadriceps palsy Obturator nerve Femoral nerve injury Rodent model 

Notes

Funding information

This work was supported by the Program of Outstanding Medical Talent of Shanghai Municipal Health Bureau [grant number 2017BR034], the Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission [grant number 15SG34], and the Project of Research Doctor of Changzheng Hospital [grant number 201712]. The sponsors had no role in the design or conduct of this research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

Supplementary material

701_2018_3565_MOESM1_ESM.mp4 (5.1 mb)
Online Resource 1 The video which was made at 16 weeks after the surgery. It demonstrated the stretch strength of the knee recovered after the surgery. (MP4 5213 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Depeng Meng
    • 1
  • Jun Zhou
    • 1
    • 2
  • Yaofa Lin
    • 1
  • Zheng Xie
    • 1
  • Huihao Chen
    • 1
  • Ronghua Yu
    • 1
  • Haodong Lin
    • 1
  • Chunlin Hou
    • 1
  1. 1.Department of Orthopedics, Changzheng HospitalSecond Military Medical UniversityShanghaiPeople’s Republic of China
  2. 2.Department of Orthopedicsthe Second People’s Hospital of KaramayKaramayPeople’s Republic of China

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