Transfer of obturator nerve for femoral nerve injury: an experiment study in rats
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Quadriceps palsy is mainly caused by proximal lesions in the femoral nerve. The obturator nerve has been previously used to repair the femoral nerve, although only a few reports have described the procedure, and the outcomes have varied. In the present study, we aimed to confirm the feasibility and effectiveness of this treatment in a rodent model using the randomized control method.
Sixty Sprague–Dawley rats were randomized into two groups: the experimental group, wherein rats underwent femoral neurectomy and obturator nerve transfer to the femoral nerve motor branch; and the control group, wherein rats underwent femoral neurectomy without nerve transfer. Functional outcomes were measured using the BBB score, muscle mass, and histological assessment.
At 12 and 16 weeks postoperatively, the rats in the experimental group exhibited recovery to a stronger stretch force of the knee and higher BBB score, as compared to the control group (p < 0.05). The muscle mass and myofiber cross-sectional area of the quadriceps were heavier and larger than those in the control group (p < 0.05). A regenerated nerve with myelinated and unmyelinated fibers was observed in the experimental group. No significant differences were observed between groups at 8 weeks postoperatively (p > 0.05).
Obturator nerve transfer for repairing femoral nerve injury was feasible and effective in a rat model, and can hence be considered as an option for the treatment of femoral nerve injury.
KeywordsNerve transfer Quadriceps palsy Obturator nerve Femoral nerve injury Rodent model
This work was supported by the Program of Outstanding Medical Talent of Shanghai Municipal Health Bureau [grant number 2017BR034], the Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission [grant number 15SG34], and the Project of Research Doctor of Changzheng Hospital [grant number 201712]. The sponsors had no role in the design or conduct of this research.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.
- 3.Bertelli JA, Soldado F, Rodríguesbaeza A, Ghizoni MF (2017) Transfer of the motor branch of the abductor digiti quinti for thenar muscle reinnervation in high median nerve injuries. J Hand Surg Am 41(1):8–15Google Scholar
- 4.Hu CH, Chang TN, Lu JC, Laurence VG, Chuang DC (2018) Comparison of surgical strategies between proximal nerve graft and/or nerve transfer and distal nerve transfer based on functional restoration of elbow flexion: a retrospective review of 147 patients. Plast Reconstr Surg 141(1):68e–79eCrossRefPubMedGoogle Scholar
- 12.Campbel AA, Eckhauser FE, Belzberg A, Campbell JN (2010) Obturator nerve transfer as an option for femoral nerve repair: case report. Neurosurgery 66(6 Suppl):375Google Scholar