Acta Neurochirurgica

, Volume 160, Issue 7, pp 1349–1353 | Cite as

Deep brain stimulation of the thalamic ventral intermediate nucleus for Benedikt’s syndrome mainly present as tremor: a long-term case observation

  • Guoxiong Cheng
  • Yuan Yang
  • Yuelong Wang
  • Hongyu Tan
  • Shizhen Zhang
Case Report - Functional Neurosurgery - Movement disorders


Benedikt’s syndrome (BS) is caused by the lesion in the midbrain and specifically manifests a series of symptoms, including ipsilateral third nerve palsy, contralateral tremor, hemiataxia, and hyperactive tendon reflexes. Deep brain stimulation (DBS) for BS emerges as a new approach and achieves successfully results. We report a successful case report of thalamic ventral intermediate (VIM) nucleus DBS for a patient with BS. During follow-up of 3 years, DBS successfully control the tremor and greatly improve his living and working quality. We consider that VIM DBS may have sustained benefit for refractory BS that mainly presents as tremor.


Benedikt’s syndrome Rubral tremor Deep brain stimulation 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Patient consent

The patient has consented to submission of this case report to the journal.

Supplementary material

701_2018_3526_MOESM1_ESM.wmv (40.4 mb)
Video 1: Video before surgery (WMV 41379 kb)
701_2018_3526_MOESM2_ESM.wmv (10.8 mb)
Video 2: Video after surgery (WMV 11016 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Guoxiong Cheng
    • 1
  • Yuan Yang
    • 2
  • Yuelong Wang
    • 2
  • Hongyu Tan
    • 3
  • Shizhen Zhang
    • 4
  1. 1.Department of NeurosurgeryThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina
  2. 2.Department of Neurosurgery, West China HospitalSichuan UniversityChengduChina
  3. 3.Department of NeurologyThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina
  4. 4.Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina

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