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Clinical presentation, progression, and treatment outcomes of moyamoya disease in the elderly

  • Clinical Article - Vascular
  • Published:
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Abstract

Background

Moyamoya disease is a vascular disorder characterized by progressive stenosis of the internal carotid artery. The presentation, progression, treatment options, and post-operative clinical outcomes for elderly (60 and older) Moyamoya patients have never been reported.

Methods

A retrospective analysis of all patients who were diagnosed with Moyamoya disease by the senior authors between 1991 and 2016 was performed. Patients who were 60 years or older at the time of surgery or last follow-up were further evaluated.

Results

Seventy patients were diagnosed with probable or definite Moyamoya disease during the study period (1991–2016). Eight patients (11.4 %; six females: two males; median age 63; range, 60–71 years) were found to be 60 years or older at the time of surgery or last follow-up and were included in the study. All patients had a modified Rankin scale (mRS) of either one or two (median 1) pre-operatively. Six patients (75 %) underwent surgical treatment on a total on seven hemispheres. Post-surgery, one patient had an improved mRS score, three had no changes, and two had worsening in their mRS scores. Both patients who did not undergo surgical interventions suffered from intra-parenchymal hemorrhages post-diagnosis.

Conclusions

Moyamoya disease is most commonly seen in young and middle-aged patients. Presentation in the elderly (defined as 60 years and older in this study) is rare, and has never been reported in the literature. In this study, both direct and indirect revascularization procedures demonstrated potential benefit in some of these patients, with stabilization of progressive symptoms.

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Author information

Authors and Affiliations

  1. Division of Neurosurgery Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Raghav Gupta

  2. Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Justin M. Moore, Nimer Adeeb, Christoph J. Griessenauer, Apar S. Patel, Michelle H. Chua, Ajith J. Thomas & Christopher S. Ogilvy

Authors
  1. Raghav Gupta
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  2. Justin M. Moore
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  3. Nimer Adeeb
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  4. Christoph J. Griessenauer
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  5. Apar S. Patel
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  6. Michelle H. Chua
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  7. Ajith J. Thomas
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  8. Christopher S. Ogilvy
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Corresponding author

Correspondence to Raghav Gupta.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Statement of human rights

IRB approval was obtained prior to beginning this retrospective analysis. For this type of study formal consent is not required.

Statement on the welfare of animals

This article does not contain any studies with animals performed by any of the authors.

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Comments

Moyamoya disease is a mysterious disease that has shown progressive stenosis of the internal carotid artery combined with "moyamoya" collateral vessels. The treatment for young-adult patients with moyamoya disease is established by using both direct and indirect revascularization surgery. However, elderly Moyamoya patients are rare, and the treatment strategy is not well known. This paper will be a good milestone for the treatment of elderly moyamoya patients.

Kenji Sugiu

Okayama, Japan

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Gupta, R., M. Moore, J., Adeeb, N. et al. Clinical presentation, progression, and treatment outcomes of moyamoya disease in the elderly. Acta Neurochir 158, 2409–2414 (2016). https://doi.org/10.1007/s00701-016-2993-z

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  • DOI: https://doi.org/10.1007/s00701-016-2993-z

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