Abstract
Background
Haemangiopericytomas (HPCs) are rare tumours characterised by aggressive behaviour with tendency to local recurrence and to metastasise. WHO grade II and grade III tumours show different progression-free survival and overall survival rates. Gross total tumour resection is still considered the treatment of choice. Adjuvant radiation therapies represent an option in the treatment strategy regardless the extent of resection. Based on this consideration, Gamma Knife radiosurgery has been introduced either as a primary treatment or as an adjuvant treatment for residual or recurrent tumours.
Method
A systematic search was performed on PubMed, Web of Science and Google Scholar for clinical series reporting Gamma Knife radiosurgery, Cyberknife and Linear Accelerator (LINAC) for the management of intracranial HPCs.
Results
Fourteen studies focusing on the effects of Gamma Knife radiosurgery for intracranial HPCs were included. Four studies reported data on Cyberknife radiosurgery and LINAC. A total of 208 patients harbouring 366 tumours have been reported. Patient’s features, radiosurgical treatment characteristics and follow-up data of the pertinent literature have been critically revised.
Conclusions
Gamma Knife radiosurgery and the other radiosurgical techniques represent a feasible and effective therapy in the management of HPCs. Tumour control and survival rate are comparable to those reported for radiotherapy. Further studies should be focused to define the exact role of Gamma Knife radiosurgery in the management of HPCs.
Similar content being viewed by others
References
Akiyama T, Yoshida K, Horiguchi T, Kawase T (2014) Management of hemangiopericytoma. In: Hayat MA (ed) Tumors of the central nervous system, vol 13. Springer, Dordrecht, pp 31–39
Alen JF, Lobato RD, Gomez PA, Boto GR, Lagares A, Ramos A, Ricoy JR (2001) Intracranial hemangiopericytoma: study of 12 cases. Acta Neurochir (Wien) 143:575–586
Chang SD, Sakamoto GT (2003) The role of radiosurgery for hemangiopericytomas. Neurosurg Focus 14:e14
Clarke MJ, Foy AB, Garces YI, Link MJ (2012) Prone positioning for successful gamma knife radiosurgical treatment of far anterior skull base lesions: a technical note. J Neurol Surg A Cent Eur Neurosurg 73:243–248
Coffey RJ, Cascino TL, Shaw EG (1993) Radiosurgical treatment of recurrent hemangiopericytomas of the meninges: preliminary results. J Neurosurg 78:903–908
Combs SE, Thilmann C, Debus J, Schulz-Ertner D (2005) Precision radiotherapy for hemangiopericytomas of the central nervous system. Cancer 104:2457–2465
Copeland WR, Link MJ, Stafford SL, Pollock BE (2014) Single-fraction stereotactic radiosurgery of meningeal hemangiopericytomas. J Neuro-Oncol 120:95–102
Coppa ND, Raper DM, Zhang Y, Collins BT, Harter KW, Gagnon GJ, Collins SP, Jean WC (2009) Treatment of malignant tumors of the skull base with multi-session radiosurgery. J Hematol Oncol 2:16
Dufour H, Metellus P, Fuentes S, Murracciole X, Regis J, Figarella-Branger D, Grisoli F (2001) Meningeal hemangiopericytoma: a retrospective study of 21 patients with special review of postoperative external radiotherapy. Neurosurgery 48:756–762, discussion 762–753
Ecker RD, Marsh WR, Pollock BE, Kurtkaya-Yapicier O, McClelland R, Scheithauer BW, Buckner JC (2003) Hemangiopericytoma in the central nervous system: treatment, pathological features, and long-term follow up in 38 patients. J Neurosurg 98:1182–1187
Fountas KN, Kapsalaki E, Kassam M, Feltes CH, Dimopoulos VG, Robinson JS, Smith JR (2006) Management of intracranial meningeal hemangiopericytomas: outcome and experience. Neurosurg Rev 29:145–153
Galanis E, Buckner JC, Scheithauer BW, Kimmel DW, Schomberg PJ, Piepgras DG (1998) Management of recurrent meningeal hemangiopericytoma. Cancer 82:1915–1920
Ganz JC (2011) Rare tumours and other lesions. In: Ganz JC (ed) Gamma knife neurosurgery. Springer, Wien, pp 349–352
Ghia AJ, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD (2013) Intracranial hemangiopericytoma and the role of radiation therapy: a population based analysis. Neurosurgery 72:203–209
Ghia AJ, Chang EL, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD (2013) Intracranial hemangiopericytoma: patterns of failure and the role of radiation therapy. Neurosurgery 73:624–630, discussion 630–621
Guthrie BL, Ebersold MJ, Scheithauer BW, Shaw EG (1989) Meningeal hemangiopericytoma: histopathological features, treatment, and long-term follow-up of 44 cases. Neurosurgery 25:514–522
Iwai Y, Yamanaka K (2009) Gamma knife radiosurgery for other primary intra-axial tumors. Prog Neurol Surg 22:129–141
Jääskeläinen J, Servo A, Haltia M, Wahlström T, Valtonen S (1985) Intracranial hemangiopericytoma: radiology, surgery, radiotherapy, and outcome in 21 patients. Surg Neurol 23:227–236
Kano H, Niranjan A, Kondziolka D, Flickinger JC, Lunsford LD (2008) Adjuvant stereotactic radiosurgery after resection of intracranial hemangiopericytomas. Int J Radiat Oncol Biol Phys 72:1333–1339
Kim JH, Jung HW, Kim YS, Kim CJ, Hwang SK, Paek SH, Kim DG, Kwun BD (2003) Meningeal hemangiopericytomas: long-term outcome and biological behavior. Surg Neurol 59:47–53, discussion 53–44
Kim JW, Kim DG, Chung HT, Paek SH, Kim YH, Han JH, Park CK, Kim CY, Jung HW (2010) Gamma Knife stereotactic radiosurgery for intracranial hemangiopericytomas. J Neuro-Oncol 99:115–122
Melone AG, D’Elia A, Santoro F, Salvati M, Delfini R, Cantore G, Santoro A (2014) Intracranial hemangiopericytoma—our experience in 30 years: a series of 43 cases and review of the literature. World Neurosurg 81:556–562
Mena H, Ribas JL, Pezeshkpour GH, Cowan DN, Parisi JE (1991) Hemangiopericytoma of the central nervous system: a review of 94 cases. Hum Pathol 22:84–91
Olson C, Yen CP, Schlesinger D, Sheehan J (2010) Radiosurgery for intracranial hemangiopericytomas: outcomes after initial and repeat Gamma Knife surgery. J Neurosurg 112:133–139
Payne BR, Prasad D, Steiner M, Steiner L (2000) Gamma surgery for hemangiopericytomas. Acta Neurochir (Wien) 142:527–536, discussion 536–527
Prado C, Navarro-Martin A, Lucas A, Macia M, Guedea F (2012) Adyuvant fractionated radiotherapy after resection of intracranial hemangiopericytoma. Rep Pract Oncol Radiother 17:237–242
Ramakrishna R, Rostomily R, Sekhar L, Rockhill J, Ferreira M (2014) Hemangiopericytoma: Radical resection remains the cornerstone of therapy. J Clin Neurosci 21:612–615
Rutkowski MJ, Bloch O, Jian BJ, Chen C, Sughrue ME, Tihan T, Barani IJ, Berger MS, McDermott MW, Parsa AT (2011) Management of recurrent intracranial hemangiopericytoma. J Clin Neurosci 18:1500–1504
Rutkowski MJ, Jian BJ, Bloch O, Chen C, Sughrue ME, Tihan T, Barani IJ, Berger MS, McDermott MW, Parsa AT (2012) Intracranial hemangiopericytoma: clinical experience and treatment considerations in a modern series of 40 adult patients. Cancer 118:1628–1636
Rutkowski MJ, Sughrue ME, Kane AJ, Aranda D, Mills SA, Barani IJ, Parsa AT (2010) Predictors of mortality following treatment of intracranial hemangiopericytoma. J Neurosurg 113:333–339
Schiariti M, Goetz P, El-Maghraby H, Tailor J, Kitchen N (2011) Hemangiopericytoma: long-term outcome revisited. Clinical article. J Neurosurg 114:747–755
Sheehan J, Kondziolka D, Flickinger J, Lunsford LD (2002) Radiosurgery for treatment of recurrent intracranial hemangiopericytomas. Neurosurgery 51:905–910, discussion 910–901
Sheehan JP, Marchan EM (2011) Intracranial hemangiopericytoma: gamma knife surgery. In: Hayat MA (ed) Tumors of the central nervous system, vol 1. Springer, New York, pp 273–278
Someya M, Sakata KI, Oouchi A, Nagakura H, Satoh M, Hareyama M (2001) Four cases of meningeal hemangiopericytoma treated with surgery and radiotherapy. Jpn J Clin Oncol 31:548–552
Sonabend AM, Zacharia BE, Goldstein H, Bruce SS, Hershman D, Neugut AI, Bruce JN (2014) The role for adjuvant radiotherapy in the treatment of hemangiopericytoma: a surveillance, epidemiology, and end results analysis. J Neurosurg 120:300–308
Soyuer S, Chang EL, Selek U, McCutcheon IE, Maor MH (2004) Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature. Cancer 100:1491–1497
Stessin AM, Sison C, Nieto J, Raifu M, Li B (2013) The role of postoperative radiation therapy in the treatment of meningeal hemangiopericytoma—experience from the SEER database. Int J Radiat Oncol Biol Phys 85:784–790
Sun S, Liu A, Wang C (2009) Gamma knife radiosurgery for recurrent and residual meningeal hemangiopericytomas. Stereotact Funct Neurosurg 87:114–119
Tian R, Hao S, Hou Z, Bian L, Zhang Y, Wu W, Xu F, Li H, Liu B (2013) Clinical characteristics and prognostic analysis of recurrent hemangiopericytoma in the central nervous system: a review of 46 cases. J Neuro-Oncol 115:53–59
Tonn JC, Westphal M, Rutka JT, Grossman SA (2006) Neuro-oncology of CNS tumors. Springer, Berlin
Veeravagu A, Jiang B, Patil CG, Lee M, Soltys SG, Gibbs IC, Chang SD (2011) CyberKnife stereotactic radiosurgery for recurrent, metastatic, and residual hemangiopericytomas. J Hematol Oncol 4:26
Vuorinen V, Sallinen P, Haapasalo H, Visakorpi T, Kallio M, Jääskeläinen J (1996) Outcome of 31 intracranial haemangiopericytomas: poor predictive value of cell proliferation indices. Acta Neurochir (Wien) 138:1399–1408
Wei G, Kang X, Liu X, Tang X, Li Q, Han J, Yin H (2015) Intracranial meningeal hemangiopericytoma: recurrences at the initial and distant intracranial sites and extraneural metastases to multiple organs. Mol Clin Oncol 3:770–774
Younis GA, Sawaya R, DeMonte F, Hess KR, Albrecht S, Bruner JM (1995) Aggressive meningeal tumors: review of a series. J Neurosurg 82:17–27
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
None.
Rights and permissions
About this article
Cite this article
Spina, A., Boari, N., Gagliardi, F. et al. The current role of Gamma Knife radiosurgery in the management of intracranial haemangiopericytoma. Acta Neurochir 158, 635–642 (2016). https://doi.org/10.1007/s00701-016-2742-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00701-016-2742-3