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Perineural tumor spread of bladder cancer causing lumbosacral plexopathy: an anatomic explanation

  • Case Report - Neurosurgical Anatomy
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An Erratum to this article was published on 21 November 2014

Abstract

We present two cases of biopsy-proven neoplastic lumbosacral plexopathy from perineural spread of bladder cancer: one patient presented with predominantly sciatic nerve involvement and the second predominantly with obturator nerve involvement. These two patterns of perineural spread from bladder cancer were supported by imaging in our cases and solidified by review of the literature. Based on the innervation of the bladder, we provide an anatomic explanation for this observation. To our best knowledge, such an anatomic, mechanistic basis for perineural tumor spread in bladder cancer has not yet been described.

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Acknowledgments

S.C. is supported by European Regional Development Fund - Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123)

Conflicts of interest

None.

Patient consent

The patients have consented to the submission of the case reports to the journal.

This study was conducted in accordance with the Helsinki Declaration of 1975, as revised in 2000 and 2009.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Warren Alpert Medical School of Brown University, Providence, RI, USA

    Daniel M. Aghion & Adeotounbo A. Oyelese

  2. Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA

    Stepan Capek & Robert J. Spinner

  3. International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic

    Stepan Capek

  4. Department of Radiology, Mayo Clinic, Rochester, MN, USA

    Benjamin M. Howe

  5. Department of Radiation Oncology, Warren Alpert Medical School of Brown University, Providence, RI, USA

    Jaroslaw T. Hepel

  6. Department of Oncology, Rhode Island Hospital, Providence, RI, USA

    Sundaresan Sambandam

Authors
  1. Daniel M. Aghion
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  2. Stepan Capek
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  3. Benjamin M. Howe
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  4. Jaroslaw T. Hepel
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  5. Sundaresan Sambandam
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  6. Adeotounbo A. Oyelese
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  7. Robert J. Spinner
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Corresponding author

Correspondence to Robert J. Spinner.

Additional information

Daniel M. Aghion and Stepan Capek both contributed equally to this manuscript.

S.C. is supported by European Regional Development Fund - Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123).

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Aghion, D.M., Capek, S., Howe, B.M. et al. Perineural tumor spread of bladder cancer causing lumbosacral plexopathy: an anatomic explanation. Acta Neurochir 156, 2331–2336 (2014). https://doi.org/10.1007/s00701-014-2257-8

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  • DOI: https://doi.org/10.1007/s00701-014-2257-8

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