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Endovascular coil embolization of unruptured intracranial aneurysms: a Korean multicenter study


Background and objective

Endovascular coil embolization has been a major treatment modality for unruptured intracranial aneurysms (UIAs) in South Korea. However, there are still few reports on the outcomes of this procedure. We performed a retrospective, multicenter study to determine how safe and effective coiling for UIA has been over the most recent 3 years in South Korea.

Materials and methods

We analyzed a total of 2,180 UIAs in 2,035 patients who were treated by coiling from January 2007 to December 2009 at 22 centers in South Korea, with a focus on patient characteristics, the location and size of the aneurysms, procedural complications, and angiographic and clinical outcomes.


Coiling was successful in 98.0 % of the cases (2,137/2,180 aneurysms). Immediate post-procedural angiography demonstrated complete occlusion in 62.6 % (1,337/2,137 aneurysms), residual neck in 32.4 % (692/2,137), and residual sac in 5.0 % (108/2,137) of the cases. The rate of any procedure-related adverse event was 6.9 % (148/2,137 aneurysms). The rates of permanent morbidity and mortality were 1.8 % (39/2,137 aneurysms) and 0.1 % (2/2,137 aneurysms), respectively. Follow-up conventional angiography or MRA at ≥6 months was performed in 85.7 % (1,832/2,137 aneurysms) of cases. Among the eligible aneurysms for follow-up angiographic analysis, major recanalization was noted in 3.9 % (72/1,832 aneurysms, mean follow-up interval, 12 months). Among these, 68 aneurysms (3.7 %) were re-treated. An aneurysm of the middle cerebral artery (MCA) was a risk factor for incomplete occlusion (P = 0.049) and major recanalization (P = 0.046). During follow-up, no aneurysmal rupture occurred.


Endovascular coil embolization of UIAs has been an effective preventive modality with low procedure-related morbidity in South Korea.

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The study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A102065).

The authors have no personal, financial, or institutional interest concerning the materials or methods used in this study or the findings specified in this paper.

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Correspondence to O-Ki Kwon.

Additional information

The Korean Unruptured Cerebral Aneurysm Coiling (KUCAC) Investigators:

Jae Seung Ahn, Byung Duk Kwon, Dooh Hoon Kwon; Asan Medical Center, Seoul, Korea

Min-Woo Baik, Seong-Rim Kim, Young Woo Kim; Bucheon St. Mary’s Hospital, Bucheon, Korea

Jun Su Byeon, Sung Nam Hwang, Taek Kyun Nam; Chung-ang University Hospital, Seoul, Korea

Jae-Hyung Choi, Jae-Taeck Huh, Myong-Jin Kang; Dong-A University Hospital, Busan, Korea

Jin Young Jung; Dong-Eui Medical Center, Busan, Korea

Keun-Tae Cho, Seung-Koan Hong, Byeong Cheol Kim; Dong Guk University Ilsan Hospital, Ilsan, Korea

Seung-Gyun Hwang; Ewha Womans University Hospital, Seoul, Korea

Chan Jong Ryu; Gil Hospital, Incheon, Korea

Dae Seob Choi, Cheol Hee Lee, In Sung Park; GyeongSang National University Hospital, Jinju, Korea

Gyojun Hwang, Seung Hun Sheen; Hallym University Chuncheon Medical Center, Chuncheon, Korea

Young Il Chun, Chang Taek Moon, Hong Gee Roh; Konkuk University Medical Center, Seoul, Korea

Jun Seok Koh, Chang Woo Ryu, Hee Sup Shin; Kyoung Hee University Hospital at Gangdong, Seoul, Korea

Dong Hun Kang, Youg-Sun Kim, Jaechan Park; Kyungpook National University Hospital, Daegu, Korea

Tae Sik Kong; Presbyterian Medical Center, Jeonju, Korea

Seung-Chyul Hong, Pyoung Jeon, Jong-Soo Kim; Samsung Medical Center, Seoul, Korea

Jae Seung Bang, O-Ki Kwon, Chang Wan Oh; Seoul National University Bundang Hospital, Bundang Korea

Young Dae Cho, Moon Hee Han, Hyun-Seung Kang; Seoul National University Hospital, Seoul, Korea

Hack-Gun Bae, Seok-Mann Yoon, Il-Gyu Yun; Soonchunhyang University Cheonan Hospital, Cheonan, Korea

Sung Jin Cho, Sukh Que Park, Sung-Tae Park; Soonchunhyang University Seoul Hospital, Seoul, Korea

Min-ho Kim, Soon Chan Kwon, Shang Hun Shin; Ulsan University Hospital, Ulsan, Korea

Myeong Sub Lee, Ji Woong Oh, Kum Whang,; Wonju Severance Christian Hospital, Wonju, Korea

Cheol Hun Jang, Young Jin Jung; Yeungnam University Medical Center, Daegu, Korea

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Kwon, S.C., Kwon, OK. & the Korean Unruptured Cerebral Aneurysm Coiling (KUCAC) Investigators. Endovascular coil embolization of unruptured intracranial aneurysms: a Korean multicenter study. Acta Neurochir 156, 847–854 (2014).

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