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Asymmetry of tonsillar ectopia, syringomyelia and clinical manifestations in adult Chiari I malformation

  • Clinical Article - Spine
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Abstract

Background

The asymmetry of tonsillar ectopia, syringomyelia, and clinical manifestations, and their correlations in adult Chiari I malformation (CIM) are seldom discussed.

Methods

Clinical and imaging data of 104 consecutive adult patients with CIM and syringomyelia were retrospectively reviewed. A method was devised to quantify tonsillar and syrinx asymmetry. Correlations between the asymmetrically displaced cerebellar tonsils, the side of the syrinx, clinical presentations, and the curve direction of scoliosis were investigated.

Results

Tonsillar ectopia was left dominant in 46 patients (44.2 %), right dominant in 49 (47.1 %), and symmetrical in nine (8.7 %). The syrinx was left deviated in 44 patients (42.3 %), right deviated in 48 (46.2 %), and centrally located in 12 (11.5 %). A significant correlation was observed between the side of tonsillar herniation and the side of the syrinx (p < 0.001), and also between the descending ratio of tonsillar herniation and the deviation ratio of the syrinx (p < 0.001). The main side the of clinical presentations showed significant correlation with the dominant side of tonsillar herniation (p = 0.009) and the side of syrinx deviation (p = 0.012). In the 49 patients (47.1 %) with associated scoliosis, the curve direction was significantly related to not only the dominant side of tonsillar ectopia (p = 0.0,28) but also the deviated side of the syrinx (p = 0.044). Moreover, the curve magnitude was significantly correlated with the distance of the tonsillar herniation (p = 0.001).

Conclusions

In adult CIM, most tonsillar herniations are asymmetrical and most syringomyelia is eccentrical. We speculate that the dominant side of tonsillar herniation determines the side of syrinx deviation, which in turn determines the main side of clinical presentations and the convex side of scoliosis. Our results suggest that the more the descended tonsil tilts to one side, the more the syrinx tilts to the same side.

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Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China

    Xiaofeng Deng, Liang Wu, Chenlong Yang, Tao Yang, Lei Zhao & Yulun Xu

  2. Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Kai Wang

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  1. Xiaofeng Deng
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  2. Kai Wang
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  3. Liang Wu
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  4. Chenlong Yang
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  5. Tao Yang
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  6. Lei Zhao
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  7. Yulun Xu
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Correspondence to Yulun Xu.

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Deng, X., Wang, K., Wu, L. et al. Asymmetry of tonsillar ectopia, syringomyelia and clinical manifestations in adult Chiari I malformation. Acta Neurochir 156, 715–722 (2014). https://doi.org/10.1007/s00701-014-2000-5

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  • DOI: https://doi.org/10.1007/s00701-014-2000-5

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