Acta Neurochirurgica

, Volume 155, Issue 7, pp 1215–1222 | Cite as

Intradural extramedullary benign spinal lesions radiosurgery. Medium- to long-term results from a single institution experience

  • Marcello MarchettiEmail author
  • Elena De Martin
  • Ida Milanesi
  • Laura Fariselli
Clinical Article - Spine



Surgery represents the first-choice treatment for spinal intradural tumours. On the other hand, whether it is most appropriate in the setting of recurrences, residual or multiple lesions remains an open question. Moreover, some patients are less than ideal candidates for surgery. In this study we report about our own radiosurgery experience in the treatment of benign intradural extramedullary tumours of the spine.


In our study we analyzed the outcomes for 18 patients (21 lesions) treated for benign intradural extramedullary lesions, with a minimum follow-up period of 32 months. The lesions included 11 meningiomas, 9 schwannomas and 1 neurofibroma.


The mean follow-up was 43 months (32–73 months). The median tumour volume was 2 cc (0.2–17.7 cc). Eleven lesions underwent single-fraction treatment (mean prescribed dose ranging from 10 to 13 Gy). The others received a multisession radiosurgery treatment (4–6 fractions) with a mean prescription dose ranging from 18.5 to 25 Gy. The maximum dose to the spinal cord ranged from 9.2 to 26 Gy. During the follow-up period, none of the lesions showed radiological evidence of progression. Neurological status was preserved or improved and no permanent sequelae were observed. Significant and durable pain relief was observed.


Although surgical excision remains the primary treatment option for most intradural tumours, radiosurgery offers a real alternative therapeutic modality, especially in case of recurrent and residual lesions or when surgery is contraindicated.


Radiosurgery Hypofractioned radiotherapy Meningiomas Neurinomas Neurofibromas Spine Cyberknife 



The authors wish to thank Dr. David W. Schaal, Accuray Incorporated, for technical and editorial assistance.

Conflicts of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.


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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Marcello Marchetti
    • 1
    • 3
    Email author
  • Elena De Martin
    • 2
  • Ida Milanesi
    • 1
  • Laura Fariselli
    • 1
  1. 1.Department of Neurosurgery, Radiotherapy UnitFondazione IRCCS Istituto Neurologico C BestaMilanItaly
  2. 2.Health DepartmentFondazione IRCCS Istituto Neurologico C BestaMilanItaly
  3. 3.Fondazione IRCCS Istituto Neurologico C BestaMilanoItaly

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