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Radiosurgical treatment of ulnar plexiform neurofibroma in a neurofibromatosis type 1 (NF1) patient

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References

  1. Adler JR Jr, Murphy MJ, Chang SD, Hancock SL (1999) Image-guided robotic radiosurgery. Neurosurgery 44:1299–1306

    PubMed  Google Scholar 

  2. Babovic-Vuksanovic D, Ballman K, Michels V, McGrann P, Lindor N, King B, Camp J, Micic V, Babovic N, Carrero X, Spinner R, O’Neill B (2006) Phase II trial of pirfenidone in adults with neurofibromatosis type 1. Neurology 67(10):1860–1862

    Article  PubMed  CAS  Google Scholar 

  3. Babovic-Vuksanovic D, Widemann BC, Dombi E, Gillespie A, Wolters PL, Toledo-Tamula MA, O’Neill BP, Fox E, MacDonald T, Beck H, Packer RJ (2007) Phase I trial of pirfenidone in children with neurofibromatosis 1 and plexiform neurofibromas. Pediatr Neurol 36(5):293–300

    Article  PubMed  Google Scholar 

  4. Chang SD, Adler JR (2001) Robotics and radiosurgery–the cyberknife. Stereotact Funct Neurosurg 76(3–4):204–208

    Article  PubMed  CAS  Google Scholar 

  5. Chang SD, Gibbs IC, Sakamoto GT, Lee E, Oyelese A, Adler JR Jr (2005) Staged stereotactic irradiation for acoustic neuroma. Neurosurgery 56(6):1254–1261

    Article  PubMed  Google Scholar 

  6. Combs SE, Volk S, Schulz-Ertner D, Huber PE, Thilmann C, Debus J (2005) Management of acoustic neuromas with fractionated stereotactic radiotherapy (FSRT): long-term results in 106 patients treated in a single institution. Int J Radiat Oncol Biol Phys 63(1):75–81

    Article  PubMed  Google Scholar 

  7. Kim A, Dombi E, Tepas K, Fox E, Martin S, Wolters P, Balis FM, Jayaprakash N, Turkbey B, Muradyan N, Choyke PL, Reddy A, Korf B, Widemann BC (2012) Phase I trial and pharmacokinetic study of sorafenib in children with neurofibromatosis type I and plexiform neurofibromas. Pediatr Blood Cancer. doi:10.1002/pbc.24281

    Google Scholar 

  8. Lin VY, Stewart C, Grebenyuk J, Tsao M, Rowed D, Chen J, Nedzelski J (2005) Unilateral acoustic neuromas: long-term hearing results in patients managed with fractionated stereotactic radiotherapy, hearing preservation surgery, and expectantly. Laryngoscope 115(2):292–296

    Article  PubMed  Google Scholar 

  9. Nadkarni TD, Rekate HL, Coons SW (1999) Plexiform neurofibroma of the cauda equina. Case report. J Neurosurg 91(1 Suppl):112–115

    PubMed  CAS  Google Scholar 

  10. Packer RJ, Gutmann DH, Rubenstein A, Viskochil D, Zimmerman RA, Vezina G, Small J, Korf B (2002) Plexiform neurofibromas in NF1: toward biologic-based therapy. Neurology 58(10):1461–1470

    Article  PubMed  CAS  Google Scholar 

  11. Prada CE, Rangwala FA, Martin LJ, Lovell AM, Saal HM, Schorry EK, Hopkin RJ (2012) Pediatric plexiform neurofibromas: impact on morbidity and mortality in neurofibromatosis type 1. J Pediatr 160(3):461–467

    Article  PubMed  Google Scholar 

  12. Puataweepong P, Janwityanujit T, Larbcharoensub N, Dhanachai M (2012) Radiation-induced peripheral malignant nerve sheath tumor arising from vestibular schwannoma after linac-based stereotactic radiation therapy: a case report and review of literatures. Case Report Med. doi:10.1155/2012/648191

    PubMed  Google Scholar 

  13. Robertson TC, Buck DA, Schmidt-Ullrich R, Powers CN, Reiter ER (2004) Isolated plexiform neurofibroma: treatment with three-dimensional conformal radiotherapy. Laryngoscope 114(7):1139–1142

    Article  PubMed  Google Scholar 

  14. Seppala MT, Haltia MJ, Sankila RJ, Jaaskelainen JE, Heiskanen O (1995) Long-term outcome after removal of spinal neurofibroma. J Neurosurg 82(4):572–577

    Article  PubMed  CAS  Google Scholar 

  15. Serletis D, Parkin P, Bouffet E, Shroff M, Drake JM, Rutka JT (2007) Massive plexiform neurofibromas in childhood: natural history and management issues. J Neurosurg 106(5 suppl):363–367

    PubMed  Google Scholar 

  16. Tamura M, Carron R, Yomo S, Arkha Y, Muraciolle X, Porcheron D, Thomassin JM, Roche PH, Régis J (2009) Hearing preservation after gamma knife radiosurgery for vestibular schwannomas presenting with high-level hearing. Neurosurgery 64(2):289–296

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors wish to thank Dr. David W. Schaal and Rose Tomey, Accuray Incorporated, for technical and editorial assistance.

Conflicts of interest

The authors hereby declare that no actual nor potential conflicts of interest exist. The authors have no financial interests in the instruments presented in this manuscript.

Funding

No funding or financial support was received for this work.

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Authors and Affiliations

  1. Department of Neurosurgery, Radiotherapy Unit, Fondazione IRCCS Istituto Neurologico C Besta, Via Celoria 11, 20124, Milan, Italy

    Marcello Marchetti & Laura Fariselli

  2. Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C Besta, Via Celoria 11, 20124, Milan, Italy

    Angelo Franzini & Vittoria Nazzi

  3. Health Department, Fondazione IRCCS Istituto Neurologico C Besta, Via Celoria 11, 20124, Milan, Italy

    Elena De Martin

Authors
  1. Marcello Marchetti
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  2. Angelo Franzini
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  3. Vittoria Nazzi
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  4. Elena De Martin
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  5. Laura Fariselli
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Corresponding author

Correspondence to Marcello Marchetti.

Additional information

Comment

This is an interesting case report on a successful radiosurgical treatment for a recurrent neurofibroma of the extremities infiltrating the skin. Benign tumors respond very well to single-session radiosurgery. In this NF1 patient, the authors have chosen hypofractionation because of the tumor’s infiltration to the skin, which seems to have resulted in a rather high dose delivered to the skin if they had opted for a single-session regime. For genetic reasons, NF1- and NF2 patients have a high propensity for the development of neoplasms. Therefore, in these patients, a radiosurgical treatment for benign tumors of the extremities should only be a secondary treatment following open surgery whenever possible. In patients with a genetic predisposition for the development of tumors, it may also be prudent to use single-session regimes whenever possible in order to minimize radiation exposure. This report adds to the growing evidence of radiosurgery applied successfully to tumors of extracranial location.

Thomas Mindermann

Zurich, Switzerland

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Marchetti, M., Franzini, A., Nazzi, V. et al. Radiosurgical treatment of ulnar plexiform neurofibroma in a neurofibromatosis type 1 (NF1) patient. Acta Neurochir 155, 553–555 (2013). https://doi.org/10.1007/s00701-012-1597-5

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  • DOI: https://doi.org/10.1007/s00701-012-1597-5

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