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Quality of life in nonfunctioning pituitary macroadenoma patients before and after surgical treatment

  • Clinical Article
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Abstract

Background

Nonfunctioning pituitary macroadenoma (NFMA) is a benign neoplasm that causes visual function disturbances and headaches and can be treated by transsphenoidal surgery (TSS). It is unclear how quality of life (QOL) changes with surgery and which QOL factors are affected by treatment.

Methods

The aim is to assess the temporal transition of QOL in NFMA patients undergoing TSS and to identify influential factors. The QOL of NFMA patients who underwent endoscopic TSS was investigated with the short-form 36 (SF-36) health survey questionnaire, general health questionnaire 30 (GHQ30), and numerical rating scale (NRS) of pain at the following three time points: immediately before, 1 month after, and 6 months after surgery.

Results

Twenty-four of 30 patients had visual deterioration. The SF-36 baseline value of visual function-impaired NFMA patients was lower than that of the normal population. SF-36 results showed that physical summary scores decreased at 1 month after the operation, but recovered up to the normal population level by 6 months. Mental summary scores generally increased at 1 month after surgery and remained stable until 6 months later. The GHQ30 results were similar to the SF-36 mental summary scores. The strongest factor related to the QOL was visual function. The amount of pain and the necessity of hormonal replacement were also influencing factors.

Conclusions

The QOL of NFMA patients is affected both physically and mentally by surgical treatment and symptoms. This QOL assessment is important for planning treatment strategies.

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Acknowledgments

This study was carried out with the cooperation of the Institute for Health Outcomes & Process Evaluation Research, which is the registry management institute of the SF-36.

Conflicts of interest

None

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Authors and Affiliations

  1. Department of Neurosurgery, Nagoya University, Graduate School of Medicine, 65 Tsurumai Showa-ku, Nagoya City, 466-8550, Japan

    Eriko Tanemura, Tetsuya Nagatani, Kazuhito Takeuchi & Toshihiko Wakabayashi

  2. Department of Neurosurgery, Yokkaichi Municipal Hospital, Yokkaichi, Japan

    Yuri Aimi

  3. Department of Neurosurgery, Fukushima Medical University, School of Medicine, Fukushima, Japan

    Yugo Kishida

Authors
  1. Eriko Tanemura
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  2. Tetsuya Nagatani
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  3. Yuri Aimi
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  4. Yugo Kishida
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  5. Kazuhito Takeuchi
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  6. Toshihiko Wakabayashi
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Corresponding author

Correspondence to Eriko Tanemura.

Additional information

Presentation at a conference: The 22nd Annual Meeting of the Japan Society for Hypothalamic and Pituitary Tumors

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Tanemura, E., Nagatani, T., Aimi, Y. et al. Quality of life in nonfunctioning pituitary macroadenoma patients before and after surgical treatment. Acta Neurochir 154, 1895–1902 (2012). https://doi.org/10.1007/s00701-012-1473-3

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  • DOI: https://doi.org/10.1007/s00701-012-1473-3

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