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Uncertainty, misunderstanding and the pedunculopontine nucleus

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References

  1. Afshar F, Watkins ES, Yap JC (1978) Stereotaxic atlas of the human brainstem and cerebellar nuclei: a variability study. Raven, New York

    Google Scholar 

  2. Aviles-Olmos I, Foltynie T, Panicker J, Cowie D, Limousin P, Hariz M, Fowler CJ, Zrinzo L (2011) Urinary incontinence following deep brain stimulation of the pedunculopontine nucleus. Acta Neurochir (Wien) 153:2357–2360

    Article  Google Scholar 

  3. Blok BF, Willemsen AT, Holstege G (1997) A PET study on brain control of micturition in humans. Brain J Neurol 120(Pt 1):111–121

    Article  Google Scholar 

  4. Chaudhuri KR, Schapira AH (2009) Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol 8:464–474

    PubMed  Article  CAS  Google Scholar 

  5. Ferraye MU, Debu B, Fraix V, Goetz L, Ardouin C, Yelnik J, Henry-Lagrange C, Seigneuret E, Piallat B, Krack P, Le Bas JF, Benabid AL, Chabardes S, Pollak P (2010) Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease. Brain 133:205–214

    PubMed  Article  CAS  Google Scholar 

  6. Galati S, Scarnati E, Mazzone P, Stanzione P, Stefani A (2008) Deep brain stimulation promotes excitation and inhibition in subthalamic nucleus in Parkinson's disease. Neuroreport 19:661–666

    PubMed  Article  Google Scholar 

  7. Holl EM, Petersen EA, Foltynie T, Martinez-Torres I, Limousin P, Hariz MI, Zrinzo L (2010) Improving targeting in image-guided frame-based deep brain stimulation. Neurosurgery 67:437–447

    PubMed  Article  Google Scholar 

  8. Khan S, Mooney L, Plaha P, Javed S, White P, Whone AL, Gill SS (2011) Outcomes from stimulation of the caudal zona incerta and pedunculopontine nucleus in patients with Parkinson's disease. Br J Neurosurg 25:273–280

    PubMed  Article  Google Scholar 

  9. Macht M, Kaussner Y, Moller JC, Stiasny-Kolster K, Eggert KM, Kruger HP, Ellgring H (2007) Predictors of freezing in Parkinson's disease: a survey of 6,620 patients. Mov Disord 22:953–956

    PubMed  Article  Google Scholar 

  10. Mazzone P, Sposato S, Insola A, Dilazzaro V, Scarnati E (2008) Stereotactic surgery of nucleus tegmenti pedunculopontine. Br J Neurosurg 22(Suppl 1):S33–40

    PubMed  Article  Google Scholar 

  11. Moro E, Hamani C, Poon YY, Al-Khairallah T, Dostrovsky JO, Hutchison WD, Lozano AM (2010) Unilateral pedunculopontine stimulation improves falls in Parkinson's disease. Brain 133:215–224

    PubMed  Article  Google Scholar 

  12. Paxinos G, Huang X-F (1995) Atlas of the human brainstem. Academic, San Diego

    Google Scholar 

  13. Schaltenbrand G, Wahren W (1977) Atlas for Stereotaxy of the Human Brain. Thieme Stuttgart

  14. Stefani A, Lozano AM, Peppe A, Stanzione P, Galati S, Tropepi D, Pierantozzi M, Brusa L, Scarnati E, Mazzone P (2007) Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain 130:1596–1607

    PubMed  Article  Google Scholar 

  15. Yelnik J (2007) PPN or PPD, what is the target for deep brain stimulation in Parkinson's disease? Brain 130:e79, author reply e80

    PubMed  Article  Google Scholar 

  16. Zrinzo L, Yoshida F, Hariz MI, Thornton J, Foltynie T, Yousry TA, Limousin P (2011) Clinical safety of brain magnetic resonance imaging with implanted deep brain stimulation hardware: large case series and review of the literature. World Neurosurg 76:164–172, discussion 169-173

    PubMed  Article  Google Scholar 

  17. Zrinzo L, Zrinzo LV, Hariz M (2007) The pedunculopontine and peripeduncular nuclei: a tale of two structures. Brain 130:e73, author reply e74

    PubMed  Article  Google Scholar 

  18. Zrinzo L, Zrinzo LV, Tisch S, Limousin PD, Yousry TA, Afshar F, Hariz MI (2008) Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization. Brain 131:1588–1598

    PubMed  Article  Google Scholar 

  19. Zrinzo L, Zrinzo LV, Massey LA, Thornton J, Parkes HG, White M, Yousry TA, Strand C, Revesz T, Limousin P, Hariz MI, Holton JL (2011) Targeting of the pedunculopontine nucleus by an MRI-guided approach: a cadaver study. J Neural Transm 118:1487-1495

    Google Scholar 

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Correspondence to Ludvic Zrinzo.

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Aviles-Olmos, I., Foltynie, T., Panicker, J. et al. Uncertainty, misunderstanding and the pedunculopontine nucleus. Acta Neurochir 154, 839–841 (2012). https://doi.org/10.1007/s00701-012-1315-3

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  • DOI: https://doi.org/10.1007/s00701-012-1315-3

Keywords

  • Local Analgesia
  • Pedunculopontine Nucleus
  • Medial Lemniscus
  • Investigational Procedure
  • Pontine Micturition Centre