Skip to main content

Single low dose adjuvant Gamma knife radiosurgery for Thyrotropin secreting pituitary adenoma

This is a preview of subscription content, access via your institution.

Fig. 1


  1. Brucker Davis F, Oldfield E, Skarulis M, Doppman JL, Weintraub BD (1999) Thyrotropin ecreting pituitary tumours: diagnostic criteria, thyroid hormone sensitivity, and treatment outcome in 25 patients followed at the National Institutes of Health. J Clin Endocrinol Metab 84:476–486

    PubMed  Article  CAS  Google Scholar 

  2. Duet M, Ajzenberg C, Benelhadj S, Lajeunie E, Lormeau B, Guillausseau PJ, Rohmer V, Vilain D, Mundler O, Warnet A (1999) Somatostatin receptor scintigraphy in pituitary adenomas: a somatostatin receptor density index can predict hormonal and tumoral efficacy of octreotide in vivo. J Nucl Med 40:1252–1256

    PubMed  CAS  Google Scholar 

  3. Jailor JW, Holub DA (1960) Remission of Grave’s disease following radiotherapy of a pituitary neoplasm. Am J Med 28:497–500

    Article  Google Scholar 

  4. Kim MS, Lee SI, Sim JH (1999) Gamma Knife radiosurgery for functioning pituitary microadenoma. Stereotact Funct Neurosurg 72:119–124

    PubMed  Article  Google Scholar 

  5. Lim YL, Leem W, Kim TS, Rhee BA, Kim GK (1998) Four years’ experiences in the treatment of pituitary adenomas with gamma knife radiosurgery. Stereotact Funct Neurosurg 70(Suppl 1):95–109

    PubMed  Article  Google Scholar 

  6. Lunsford LD, Witt TC, Kondziolka D, Flickinger JC (1995) Stereotactic radiosurgery of anterior skull base tumors. Clin Neurosurg 42:99–118

    PubMed  CAS  Google Scholar 

  7. Mindermann T, Wilson CB (1993) Thyrotrophin-producing pituitary adenomas. J Neurosurg 79:521–527

    PubMed  Article  CAS  Google Scholar 

  8. Ohki M, Sato K, Tuchiya D, Sato S, Saito S, Kinjo T, Kayama T, Jokura H, Yoshimoto T (1999) A case of TSH-secreting pituitary adenoma associated with an unruptured aneurysm: successful treatment by twostage operation and gamma-knife. No To Shinkei 51:895–899

    PubMed  CAS  Google Scholar 

  9. Rocher FP, Sentenac I, Berger C, Marquis I, Romestaing P, Gerard JP (1995) Stereotactic radiosurgery: The Lyon experience. Acta Neurochir (Wein) 63:109–114

    CAS  Google Scholar 

  10. Socin HV, Chanson P, Delemer B, Tabarin A, Rohmer V, Mockel J, Stevenaert A, Beckers A (2003) The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients. Eur J Endocrinol 148:433–442

    PubMed  Article  CAS  Google Scholar 

  11. Thorén M, Rähn T, Guo WY, Werner S (1991) Stereotactic radiosurgery with the cobalt-6- gamma unit in the treatment of growth harmone producing pituitary tumors. Neurosurgery 29:663–668

    PubMed  Article  Google Scholar 

Download references

Conflicts of interest


Author information

Authors and Affiliations


Corresponding author

Correspondence to Manish S. Sharma.

Additional information


This is an interesting case report of rapid response to gamma knife therapy of a TSHoma. There have been sporadic comments, usually made during the discussion at pituitary sessions at neurosurgical conferences, of highly sensitive adenomas responding rapidly to low doses of gamma knife therapy. Perhaps this is one of those.

Michael Powell

London, UK

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kasliwal, M.K., Gupta, A. & Sharma, M.S. Single low dose adjuvant Gamma knife radiosurgery for Thyrotropin secreting pituitary adenoma. Acta Neurochir 154, 665–666 (2012).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


  • Octreotide
  • Pituitary Adenoma
  • Hypopituitarism
  • Antithyroid Drug
  • Hormonal Evaluation