Acta Neurochirurgica

, Volume 154, Issue 3, pp 509–515 | Cite as

Assessment of non-motor hearing symptoms in hemifacial spasm using magnetoencephalography

  • Young Seok Park
  • Bong Soo Kim
  • Dong Kyu Lee
  • Seung-Koo Lee
  • Hyuk Chan Kwon
  • Kiwoong Kim
  • Yong Ho Lee
  • Jin Woo Chang
Clinical Article



Hemifacial spasm patients often suffer from non-motor symptoms such as tinnitus. These non-motor symptoms are known to be associated with changes in cortical activity. Magnetoencephalography (MEG) is a technique that can record brain activity noninvasively. To determine the usefulness of MEG in assessing changes in cortical activity associated with non-motor hearing symptoms in hemifacial spasm patients.


We used MEG to evaluate the reactivity of the auditory cortex in 26 hemifacial spasm patients. We divided patients into a subjective tinnitus group (n = 10) and a non-tinnitus group (n = 16). The latency and amplitude of the most prominent deflection, N100m, was compared between the two groups.


There was a significant difference in the pure tone audiogram on the spasm side compared with the non-spasm side. After stimulation on the spasm side, the amplitude of the N100m peak in the contralateral hemisphere was lower in the subjective tinnitus group than in the non-tinnitus group.


Our results indicate that MEG can detect differences in cortical activity between hemifacial spasm patients with and without tinnitus. This suggests that MEG can identify changes in cortical activity associated with non-motor symptoms.


Dysynchronization Hearing Hemifacial spasm MEG 


  1. 1.
    De Ridder D, De Mulder G, Verstraeten E, Seidman M, Elisevich K, Sunaert S, Kovacs S, Van der Kelen K, Van de Heyning P, Moller A (2007) Auditory cortex stimulation for tinnitus. Acta Neurochir Suppl 97:451–462PubMedCrossRefGoogle Scholar
  2. 2.
    De Ridder D, De Mulder G, Verstraeten E, Van der Kelen K, Sunaert S, Smits M, Kovacs S, Verlooy J, Van de Heyning P, Moller AR (2006) Primary and secondary auditory cortex stimulation for intractable tinnitus. ORL J Otorhinolaryngol Relat Spec 68:48–54, discussion 54–45PubMedCrossRefGoogle Scholar
  3. 3.
    Eggermont JJ, Roberts LE (2004) The neuroscience of tinnitus. Trends Neurosci 27:676–682PubMedCrossRefGoogle Scholar
  4. 4.
    Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N, Larbig W, Taub E (1995) Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 375:482–484PubMedCrossRefGoogle Scholar
  5. 5.
    Fregni F, Marcondes R, Boggio PS, Marcolin MA, Rigonatti SP, Sanchez TG, Nitsche MA, Pascual-Leone A (2006) Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Eur J Neurol 13:996–1001PubMedCrossRefGoogle Scholar
  6. 6.
    Gardner WJ (1968) Trigeminal neuralgia. Clin Neurosurg 15:1–56PubMedGoogle Scholar
  7. 7.
    Harrison RV, Ibrahim D, Mount RJ (1998) Plasticity of tonotopic maps in auditory midbrain following partial cochlear damage in the developing chinchilla. Exp Brain Res 123:449–460PubMedCrossRefGoogle Scholar
  8. 8.
    Kaas JH (1991) Plasticity of sensory and motor maps in adult mammals. Annu Rev Neurosci 14:137–167PubMedCrossRefGoogle Scholar
  9. 9.
    Kaltenbach JA, Afman CE (2000) Hyperactivity in the dorsal cochlear nucleus after intense sound exposure and its resemblance to tone-evoked activity: a physiological model for tinnitus. Hear Res 140:165–172PubMedCrossRefGoogle Scholar
  10. 10.
    Kleinjung T, Eichhammer P, Langguth B, Jacob P, Marienhagen J, Hajak G, Wolf SR, Strutz J (2005) Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus. Otolaryngol Head Neck Surg 132:566–569PubMedCrossRefGoogle Scholar
  11. 11.
    Kuroki A, Moller AR (1994) Facial nerve demyelination and vascular compression are both needed to induce facial hyperactivity: a study in rats. Acta Neurochir (Wien) 126:149–157CrossRefGoogle Scholar
  12. 12.
    Lee Y, Kwon H, Kim J, Park Y, Park J (1998) Double relaxation oscillation SQUID with high flux-to-voltage transfer and its application to a biomagnetic multichannel system. J Korean Phys Soc 32:600–605Google Scholar
  13. 13.
    Llinas R, Urbano FJ, Leznik E, Ramirez RR, van Marle HJ (2005) Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect. Trends Neurosci 28:325–333PubMedCrossRefGoogle Scholar
  14. 14.
    Londero A, Langguth B, De Ridder D, Bonfils P, Lefaucheur JP (2006) Repetitive transcranial magnetic stimulation (rTMS): a new therapeutic approach in subjective tinnitus? Neurophysiol Clin 36:145–155PubMedCrossRefGoogle Scholar
  15. 15.
    Martinelli P, Giuliani S, Ippoliti M (1992) Hemifacial spasm due to peripheral injury of facial nerve: a nuclear syndrome? Mov Disord 7:181–184PubMedCrossRefGoogle Scholar
  16. 16.
    Moller AR (1991) Interaction between the blink reflex and the abnormal muscle response in patients with hemifacial spasm: results of intraoperative recordings. J Neurol Sci 101:114–123PubMedCrossRefGoogle Scholar
  17. 17.
    Moller AR, Jannetta PJ (1984) On the origin of synkinesis in hemifacial spasm: results of intracranial recordings. J Neurosurg 61:569–576PubMedCrossRefGoogle Scholar
  18. 18.
    Moller MB, Moller AR (1985) Loss of auditory function in microvascular decompression for hemifacial spasm. Results in 143 consecutive cases. J Neurosurg 63:17–20PubMedCrossRefGoogle Scholar
  19. 19.
    Muhlnickel W, Elbert T, Taub E, Flor H (1998) Reorganization of auditory cortex in tinnitus. Proc Natl Acad Sci U S A 95:10340–10343PubMedCrossRefGoogle Scholar
  20. 20.
    Nielsen VK (1984) Pathophysiology of hemifacial spasm: I. Ephaptic transmission and ectopic excitation. Neurology 34:418–426PubMedGoogle Scholar
  21. 21.
    Norena A, Micheyl C, Chery-Croze S, Collet L (2002) Psychoacoustic characterization of the tinnitus spectrum: implications for the underlying mechanisms of tinnitus. Audiol Neurootol 7:358–369PubMedCrossRefGoogle Scholar
  22. 22.
    Plewnia C, Bartels M, Gerloff C (2003) Transient suppression of tinnitus by transcranial magnetic stimulation. Ann Neurol 53:263–266PubMedCrossRefGoogle Scholar
  23. 23.
    Rajan R, Irvine DR (1998) Neuronal responses across cortical field A1 in plasticity induced by peripheral auditory organ damage. Audiol Neurootol 3:123–144PubMedCrossRefGoogle Scholar
  24. 24.
    Ramirez RR, Kopell BH, Butson CR, Gaggl W, Friedland DR, Baillet S (2009) Neuromagnetic source imaging of abnormal spontaneous activity in tinnitus patient modulated by electrical cortical stimulation. Conf Proc IEEE Eng Med Biol Soc 2009:1940–1944PubMedGoogle Scholar
  25. 25.
    Rauschecker JP (1999) Auditory cortical plasticity: a comparison with other sensory systems. Trends Neurosci 22:74–80PubMedCrossRefGoogle Scholar
  26. 26.
    Robertson D, Irvine DR (1989) Plasticity of frequency organization in auditory cortex of guinea pigs with partial unilateral deafness. J Comp Neurol 282:456–471PubMedCrossRefGoogle Scholar
  27. 27.
    Rudzinska M, Wojcik M, Szczudlik A (2010) Hemifacial spasm non-motor and motor-related symptoms and their response to botulinum toxin therapy. J Neural Transm 117:765–772Google Scholar
  28. 28.
    Ryan AF, Woolf NK (1988) Development of tonotopic representation in the Mongolian gerbil: a 2-deoxyglucose study. Brain Res 469:61–70PubMedGoogle Scholar
  29. 29.
    Ryu H, Yamamoto S, Sugiyama K, Nozue M (1998) Neurovascular compression syndrome of the eighth cranial nerve. What are the most reliable diagnostic signs? Acta Neurochir (Wien) 140:1279–1286CrossRefGoogle Scholar
  30. 30.
    Sakaki T, Morimoto T, Miyamoto S, Kyoi K, Utsumi S, Hyo Y (1987) Microsurgical treatment of patients with vestibular and cochlear symptoms. Surg Neurol 27:141–146PubMedCrossRefGoogle Scholar
  31. 31.
    Virtanen J, Ahveninen J, Ilmoniemi RJ, Naatanen R, Pekkonen E (1998) Replicability of MEG and EEG measures of the auditory N1/N1m-response. Electroencephalogr Clin Neurophysiol 108:291–298PubMedCrossRefGoogle Scholar
  32. 32.
    Wang A, Jankovic J (1998) Hemifacial spasm: clinical findings and treatment. Muscle Nerve 21:1740–1747PubMedCrossRefGoogle Scholar
  33. 33.
    Weisz N, Dohrmann K, Elbert T (2007) The relevance of spontaneous activity for the coding of the tinnitus sensation. Prog Brain Res 166:61–70PubMedCrossRefGoogle Scholar
  34. 34.
    Wilkins RH (1991) Hemifacial spasm: a review. Surg Neurol 36:251–277PubMedCrossRefGoogle Scholar
  35. 35.
    Wuertenberger CJ, Rosahl SK (2009) Vertigo and tinnitus caused by vascular compression of the vestibulocochlear nerve, not intracanalicular vestibular schwannoma: review and case presentation. Skull Base 19:417–424PubMedCrossRefGoogle Scholar
  36. 36.
    Yap L, Pothula VB, Lesser T (2008) Microvascular decompression of cochleovestibular nerve. Eur Arch Otorhinolaryngol 265:861–869PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Young Seok Park
    • 1
    • 4
  • Bong Soo Kim
    • 1
  • Dong Kyu Lee
    • 1
  • Seung-Koo Lee
    • 2
  • Hyuk Chan Kwon
    • 3
  • Kiwoong Kim
    • 3
  • Yong Ho Lee
    • 3
  • Jin Woo Chang
    • 1
  1. 1.Department of NeurosurgeryYonsei University College of MedicineSeodaemoon-GuKorea
  2. 2.Department of Radiology, Severance Hospital, MEG Center, Severance Hospital Brain Korea 21 Project for Medical Science, Brain Research InstituteYonsei University College of MedicineSeoulKorea
  3. 3.Center for Brain and Cognitive Science ResearchKorea Research Institute of Standards and ScienceDaejeonKorea
  4. 4.Department of Neurosurgery, Bundang CHA Medical CenterCHA UniversitySeongnamKorea

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