Skip to main content
SpringerLink
Log in

Preserved cognition after deep brain stimulation (DBS) in the subthalamic area for Parkinson's disease: a case report

  • Case Report
  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Abstract

At present, subthalamic nucleus (STN) stimulation is the preferred procedure for the amelioration of motor symptoms in medication refractory Parkinson's disease. Results are however impaired by negative impacts on mood, cognition, incentive, and social judgment. Alternative targets are therefore explored. We describe a case with stimulation of subthalamic fibre tracts that showed clear improvement of cognitive and social abilities. Avoiding the STN may be advantageous in progressive Parkinson's disease to avoid non-motor complications and enhance quality of life.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Abbreviations

ct:

Computed tomography

fct:

Fasciculus cerebello-thalamicus

STN:

Subthalamic nucleus

RAPRL:

Radiatio prelemniscalis

References

  1. Alberts JL, Voelcker-Rehage C, Hallahan K, Vitek M, Bamzai R, Vitek JL (2008) Bilateral subthalamic stimulation impairs cognitive-motor performance in Parkinson's disease patients. Brain 131:3348–3360

    Article  PubMed  Google Scholar 

  2. Anderson VC, Burchiel KJ, Hogarth P, Favre J, Hammerstad JP (2005) Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson's disease. Arch Neurol 62:554–560

    Article  PubMed  Google Scholar 

  3. Burn DJ, Troster AI (2004) Neuropsychiatric complications of medical and surgical therapies for Parkinson's disease. J Geriatr Psychiatry Neurol 17:172–180

    Article  PubMed  Google Scholar 

  4. Cools R, Miyakawa A, Sheridan M, D'Esposito M (2010) Enhanced frontal function in Parkinson's disease. Brain 133:225–233

    Article  CAS  PubMed  Google Scholar 

  5. Denheyer M, Kiss ZH, Haffenden AM (2009) Behavioral effects of subthalamic deep brain stimulation in Parkinson's disease. Neuropsychologia 47:3203–3209

    Article  CAS  PubMed  Google Scholar 

  6. Drapier D, Drapier S, Sauleau P, Haegelen C, Raoul S, Biseul I, Peron J, Lallement F, Rivier I, Reymann JM, Edan G, Verin M, Millet B (2006) Does subthalamic nucleus stimulation induce apathy in Parkinson's disease? J Neurol 253:1083–1091

    Article  CAS  PubMed  Google Scholar 

  7. Gallay MN, Jeanmonod D, Liu J, Morel A (2008) Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional stereotactic neurosurgery. Brain Struct Funct 212:443–463

    Article  PubMed  Google Scholar 

  8. Kitagawa M, Murata J, Uesugi H, Kikuchi S, Saito H, Tashiro K, Sawamura Y (2005) Two-year follow-up of chronic stimulation of the posterior subthalamic white matter for tremor-dominant Parkinson's disease. Neurosurgery 56:281–289, discussion 281-289

    Article  PubMed  Google Scholar 

  9. Kulisevsky J, Berthier ML, Gironell A, Pascual-Sedano B, Molet J, Pares P (2002) Mania following deep brain stimulation for Parkinson's disease. Neurology 59:1421–1424

    CAS  PubMed  Google Scholar 

  10. Maks CB, Butson CR, Walter BL, Vitek JL, McIntyre CC (2009) Deep brain stimulation activation volumes and their association with neurophysiological mapping and therapeutic outcomes. J Neurol Neurosurg Psychiatry 80:659–666

    Article  CAS  PubMed  Google Scholar 

  11. Morel A (2007) Stereotactic atlas of the human thalamus and basal ganglia. Informa Healthcare, New York

    Google Scholar 

  12. Plaha P, Khan S, Gill SS (2008) Bilateral stimulation of the caudal zona incerta nucleus for tremor control. J Neurol Neurosurg Psychiatry 79:504–513

    Article  CAS  PubMed  Google Scholar 

  13. Smeding HM, Goudriaan AE, Foncke EM, Schuurman PR, Speelman JD, Schmand B (2007) Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson disease. J Neurol Neurosurg Psychiatry 78:517–519

    Article  CAS  PubMed  Google Scholar 

  14. Velasco F, Jimenez F, Perez ML, Carrillo-Ruiz JD, Velasco AL, Ceballos J, Velasco M (2001) Electrical stimulation of the prelemniscal radiation in the treatment of Parkinson's disease: an old target revised with new techniques. Neurosurgery 49:293–306, discussion 306–298

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Klinik Hirslanden, Witellikerstrasse 40, CH-8032, Zürich, Switzerland

    Donatus Cyron & Kai Scheufler

  2. Kopfwehzentrum Hirslanden Zürich, Forchstrasse 424, CH-8702, Zollikon, Switzerland

    Marion Funk

  3. Arztpraxis Dr. med. Jürg Jäger, Erachfeldstrasse 2, 8180, Bülach, ZH, Switzerland

    Marie-An Deletter

Authors
  1. Donatus Cyron
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marion Funk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marie-An Deletter
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kai Scheufler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Donatus Cyron.

Additional information

Financial disclosures and conflicts of interest

The authors have no financial interest in any materials or equipment used in the study.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cyron, D., Funk, M., Deletter, MA. et al. Preserved cognition after deep brain stimulation (DBS) in the subthalamic area for Parkinson's disease: a case report. Acta Neurochir 152, 2097–2100 (2010). https://doi.org/10.1007/s00701-010-0755-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00701-010-0755-x

Keywords

Search

Navigation