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Cardiovascular response during trigeminal ganglion compression for trigeminal neuralgia according to the use of local anesthetics

  • Clinical Article
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Abstract

Objectives

There are controversies about the use of local anesthetics during balloon compression for trigeminal neuralgia (TN) as a protective factor for cardiovascular events. The objective of this study was to investigate cardiovascular parameters (blood pressure and heart rate [HR]) of patients that underwent trigeminal balloon compression with local anesthetics compared to a control group (placebo).

Methods

This is a randomized controlled study; 55 patients were randomized into two groups: study (deep sedation and trigeminal block with 0.8-mL lidocaine 2%) and control group (deep sedation and trigeminal injection of 0.8-mL saline). Blood pressure and HR were measured in five distinct moments: preoperative, during puncture for local anesthesia/placebo, during puncture with the catheter, during balloon compression, and final evaluation. Statistical analysis was performed with Pearson’s χ 2 and McNemar tests and the analysis of variance for repetitive measures.

Results

The means of systolic and diastolic blood pressures (SBP and DBP, respectively) were higher in the control group when compared to the study group at the evaluation during puncture with the catheter (p < 0.001) and balloon compression (p < 0.001 and p = 0.018 for DBP and SBP, respectively). There was an increase in the HR in the control group during the procedure (p = 0.017).

Conclusion

The use of local anesthetics during the trigeminal balloon compression for TN can have a preventive role for the risk of cardiovascular events.

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Authors and Affiliations

  1. Neurology Department, Hospital das Clinicas, Medical School, University of São Paulo, São Paulo, SP, Brazil

    Adriana Tanaka Tibano

  2. Escola de Artes, Ciências e Humanidades e Orofacial Pain Group, Hospital das Clínicas, Medical School, University of Sao Paulo, São Paulo, SP, Brazil

    Silvia Regina D. T. de Siqueira

  3. Functional Neurosurgery Division, Neurology Department, Hospital das Clinicas, Medical School, University of São Paulo, São Paulo, SP, Brazil

    José Cláudio Marinho da Nóbrega

  4. Pain Center and Functional Neurosurgery, Neurology Department, Hospital das Clinicas, Medical School, University of São Paulo, São Paulo, SP, Brazil

    Manoel Jacobsen Teixeira

  5. Rua Carlos Weber, 1319 apto 164-P Vila Leopoldina, 05303-000, Sao Paulo, SP, Brazil

    Silvia Regina D. T. de Siqueira

Authors
  1. Adriana Tanaka Tibano
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  2. Silvia Regina D. T. de Siqueira
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  3. José Cláudio Marinho da Nóbrega
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  4. Manoel Jacobsen Teixeira
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Corresponding author

Correspondence to Silvia Regina D. T. de Siqueira.

Additional information

There are no conflicts of interest in this study.

This study was supported by the Foundation of Research of Sao Paulo (FAPESP) 2008/05078-0.

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Tibano, A.T., de Siqueira, S.R.D.T., da Nóbrega, J.C.M. et al. Cardiovascular response during trigeminal ganglion compression for trigeminal neuralgia according to the use of local anesthetics. Acta Neurochir 152, 1347–1351 (2010). https://doi.org/10.1007/s00701-010-0664-z

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  • DOI: https://doi.org/10.1007/s00701-010-0664-z

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