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Cerebellar glioblastomas: pathophysiology, clinical presentation and management

Acta Neurochirurgica volume 151, pages 653–657 (2009)Cite this article

Summary

Glioblastoma multiforme usually affects the cerebral hemispheres with the peak age of onset in the sixth or seventh decade, while cerebellar glioblastoma multiforme is a rare tumour especially in younger patients. Most result from de-differentiation from low grade astrocytoma (secondary glioblastoma) or can develop de novo (primary glioblastoma). Primary glioblastomas develop in older patients while secondary glioblastomas develop in younger patients and contain TP53 mutations as the earliest detectable change. We report a 28 year old patient with primary multi-focal cerebellar glioblastoma multiforme and review the pathophisiology, clinical presentation, diagnosis and treatment of cerebellar glioblastomas.

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Conflict of interest statement

There is no conflict of interest

Author information

Affiliations

  1. Department of Neurosurgery, University Hospital Dubrava, HR-10000, Zagreb, Croatia

    Gordan Grahovac & Damir Tomac

  2. Department of Pathology, University Hospital Dubrava, Zagreb, Croatia

    Smiljka Lambasa

  3. Laboratory of Molecular Oncology, Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb, Croatia

    Arijana Zoric

  4. University Department of Neurology, Zagreb School of Medicine and University Hospital Center, Zagreb, Croatia

    Mario Habek

Authors
  1. Gordan Grahovac
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  2. Damir Tomac
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  3. Smiljka Lambasa
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  4. Arijana Zoric
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  5. Mario Habek
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Corresponding author

Correspondence to Gordan Grahovac.

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Authors’ contributions

Study concept and design: Grahovac and Habek. Acquisition of data: Grahovac, Tomac, Lambasa and Zoric. Analysis and interpretation of data: Grahovac, Tomac, Lambasa and Zoric. Drafting of the manuscript: Grahovac and Habek. Critical revision of the manuscript for important intellectual content: Grahovac, Tomac, Lambasa, Zoric and Habek. Administrative, technical, and material support: Grahovac and Habek.

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Grahovac, G., Tomac, D., Lambasa, S. et al. Cerebellar glioblastomas: pathophysiology, clinical presentation and management. Acta Neurochir 151, 653–657 (2009). https://doi.org/10.1007/s00701-009-0286-5

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  • DOI: https://doi.org/10.1007/s00701-009-0286-5

Keywords

  • Glioblastoma multiforme
  • Cerebellum
  • Primary glioblastoma
  • p53
  • p73