Advertisement

Acta Neurochirurgica

, Volume 150, Issue 5, pp 491–496 | Cite as

Atypical teratoid/rhabdoid tumour in sella turcica in an adult

  • K. Arita
  • K. Sugiyama
  • T. Sano
  • H. Oka
Case Report

Summary

Although atypical teratoid rhabdoid tumours preferentially arise in the posterior fossa of infants, we encountered a 56 year old woman with an atypical teratoid rhabdoid tumour located in the sella. She presented with right abducent and oculomotor nerve paresis. Magnetic resonance imaging demonstrated an intrasellar tumour impinging on the right cavernous sinus. Microscopically, the tumour was composed of cells with rhabdoid features; we observed atypia, eccentric nuclei, and intracytoplasmic inclusion bodies. The Ki-67 labeling index was around 30%. The tumour cells were positive for vimentin, epithelial membrane antigen, and neurofilament, but negative for INI1. Despite extended local brain and whole-spine irradiation she died of neural axis dissemination.

Keywords: Atypical; teratoid rhabdoid tumour; sella turcica; INI1. 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Burch, LA, Hill, DA, Cai, DX, Levy, BK, Dehner, LP, Perry, A 2001A role of fluorescence in situ hybridisation detection of chromosome 22q dosage in distinguishing atypical teratoid/rhabdoid tumours from medulloblastoma/central primitive neuroectodermal tumoursHum Pathol32156162CrossRefGoogle Scholar
  2. Haberler, C, Laggner, U, Slavc, I, Czech, T, Ambros, IM, Ambros, PF, Budka, H, Hainfellner, JA 2006Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumours: lack of INI1 in atypical teratoid/rhabdoid tumours and in a fraction of primitive neuroectodermal tumours without rhabdoid phenotypeAm J Surg Pathol3014621468PubMedCrossRefGoogle Scholar
  3. Kuge, A, Kayama, T, Tsuchiya, D, Kawakami, K, Saito, S, Nakazato, Y, Suzuki, H 2000Suprasellar primary rhabdoid tumour in an adults: a case reportNo Shinkei Geka28351358PubMedGoogle Scholar
  4. Lutterbach, J, Liegibel, J, Koch, D, Madlinger, A, Frommhold, H, Pagenstecher, A 2001Atypical teratoid/rhabdoid tumours in adult patientsJ Neuro-Oncol524956CrossRefGoogle Scholar
  5. Meyers, SP, Khademian, ZP, Biegel, JA, Chuang, SH, Korones, DN, Zimmerman, RA 2006Primary intracranial atypical teratoid/rhabdoid tumour of infancy and child hood: MRI features and patient outcomesAm J Neuroradiol27962971PubMedGoogle Scholar
  6. Oka, H, Scheithauer, BW 1999Clinicopathological characteristics of atypical teratoid/rhabdoid tumourNeurol Med Chir (Tokyo)39510518CrossRefGoogle Scholar
  7. Raisanen, J, Biegel, JA, Hatanpaa, KJ, Judkins, A, White, CL, Perry, A 2005Chromosome 22q deletions in atypical teratoid/rhabdoid tumours in adultsBrain Pathol152328PubMedCrossRefGoogle Scholar
  8. Rorke, LB, Packer, RJ, Biegel, JA 1996Central nervous system atypical teratoid/rhabdoid tumours of infancy and childhood: definition of an entityJ Neurosurg855665PubMedGoogle Scholar
  9. Rorke, LB, Biegel, JA 2000Atypical teratoid/rhabdoid tumourKleihues, PCavenee, WK eds. World health organization classifications of tumours, pathology and genetics of tumours of the nervous systemIRAC PressLyon145148Google Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Department of Neurosurgery, Graduate School of Medical and Dental SciencesKagoshima UniversityKagoshimaJapan
  2. 2.Department of Neurosurgery, Graduate School of Biomedical ScienceHiroshima UniversityHiroshimaJapan
  3. 3.Department of Human Pathology, Institute of Health BioscienceUniversity of Tokushima Graduate SchoolTokushimaJapan
  4. 4.Department of NeurosurgeryKitasato University School of MedicineSagamiharaJapan

Personalised recommendations