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Endothelin-1 in plasma, cisternal CSF and microdialysate following aneurysmal SAH

  • Clinical Article
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An Erratum to this article was published on 01 March 2006

Summary

Objective. Endothelin-1 (ET-1) is postulated to play an important role in the development of cerebral vasospasm (CVS) following SAH. This study was conducted to investigate the time course of ET-release in three different sources: CSF, plasma and microdialysate.

Methods. In a prospective study ET-1-concentrations were measured in plasma, cisternal CSF and microdialysate in 20 patients with aneurysmal SAH for at least 8 days after hemorrhage.

Results. ET-1 concentration in microdialysate was almost four times higher compared to CSF and plasma. (p<0.001) Only in CSF ET-1-release showed a significant increase over time with highest values on day 5 post ictus (p = 0.03). This was parallel to the increase of transcranial Doppler velocities. ET-1 in plasma and microdialysate did not change over time.

Conclusion. ET-1 may have a different biological function in different biological tissues. Only ET-1 in CSF seemed to be associated with CVS.

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  1. Department of Neurosurgery, University Hospital Giessen, Giessen, Germany

    S. Kästner, M. F. Oertel, W. Scharbrodt, M. Krause, D.-K. Böker & W. Deinsberger

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  1. S. Kästner
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  2. M. F. Oertel
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An erratum to this article is available at http://dx.doi.org/10.1007/s00701-006-0757-x.

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Kästner, S., Oertel, M., Scharbrodt, W. et al. Endothelin-1 in plasma, cisternal CSF and microdialysate following aneurysmal SAH. Acta Neurochir (Wien) 147, 1271–1279 (2005). https://doi.org/10.1007/s00701-005-0633-0

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