Summary
Radiation-induced cavernous malformations are rarely reported, and most cases have been children. We describe two adult patients with cavernous malformation after irradiation for astrocytoma. Magnetic resonance (MR) imaging, at their ages of 53 years, showed a cavernous malformation in the irradiated field 26 and 10 years after resection and irradiation, respectively. Cavernous malformations were confirmed by the histopathological examination in the both cases. Radiation-induced cavernous malformations are rare in adult patients with astrocytoma. One reason why we found two such cases was that these patients had been successfully treated for astrocytoma and had long follow-up periods.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A Amirjamshidi K Abbassioun (2000) ArticleTitleRadiation-induced tumors of the central nervous system occurring in childhood and adolescence. Child’s Nerv Syst 16 390–397 Occurrence Handle10.1007/s003819900125
JE Baumgartner JL Ater CS Ha JF Kuttesch NE Leeds GN Fuller RJ Wilson (2003) ArticleTitlePathologically proven cavernous angiomas of the brain following radiation therapy for pediatric brain tumors. Pediatr Neurosurg 39 201–207 Occurrence Handle10.1159/000072472 Occurrence Handle12944701
GK Bejjani AJ Caputy RN Kurtzke DH Duong LN Sekhar (1997) ArticleTitleRemote hemorrhage of a pontine cavernous angioma fifty-two years after cerebral irradiation. Acta Neurochir (Wien) 139 583–584
OD Curling SuffixJr DL Kelly SuffixJr AD Elster TE Craven (1991) ArticleTitleAn analysis of the natural history of cavernous angiomas. J Neurosurg 75 702–708 Occurrence Handle1919691
PW Detwiler RW Porter JM Zabramski RF Spetzler (1998) ArticleTitleRadiation-induced cavernous malformation. J Neurosurg 89 167–168
S Heckl A Aschoff S Kunze (2002) ArticleTitleRadiation-induced cavernous hemangiomas of the brain. A late effect predominantly in children. Cancer 94 3285–3291 Occurrence Handle10.1002/cncr.10596 Occurrence Handle12115362
JJ Larson WS Ball KE Bove KR Crone JM Tew SuffixJr (1998) ArticleTitleFormation of intracerebral cavernous malformations after radiation treatment for central nervous system meoplasia in children. J Neurosurg 88 51–56 Occurrence Handle9420072
PM Novelli DH Reigel PL Gleason E Yunis (1997) ArticleTitleMultiple cavernous angiomas after high-dose whole-brain radiation therapy. Pediatr Neurosurg 26 322–325 Occurrence Handle9485161
WC Olivero P Deshmukh M Gujrati (2000) ArticleTitleRadiation-induced cavernous angioma mimicking metastatic disease. Br J Neurosurg 14 575–578 Occurrence Handle10.1080/02688690050206756 Occurrence Handle11272041
TY Poussaint J Siffert PD Barnes SL Pomeroy LC Goumnerova DC Anthony SE Sallan NJ Tarbell (1995) ArticleTitleHemorrhagic vasculopathy after treatment of central nervous system neoplasia in childhood: diagnosis and follow-up. AJNR 16 693–699 Occurrence Handle7611024
E Pozzati F Giangaspero F Marliani N Acciarri (1996) ArticleTitleOccult cerebrovascular malformations after irradiation. Neurosurgery 39 677–684 Occurrence Handle10.1097/00006123-199610000-00004 Occurrence Handle8880758
JR Robinson IA Awad JR Little (1991) ArticleTitleNatural history of the cavernous angioma. J Neurosurg 75 709–714 Occurrence Handle1919692
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Furuse, M., Miyatake, SI. & Kuroiwa, T. Cavernous malformation after radiation therapy for astrocytoma in adult patients: report of 2 cases. Acta Neurochir (Wien) 147, 1097–1101 (2005). https://doi.org/10.1007/s00701-005-0579-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00701-005-0579-2