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Microchimica Acta

, Volume 136, Issue 1–2, pp 91–97 | Cite as

Multiwavelength Spectrophotometric Resolution of the Micro-Equilibria of a Triprotic Amphoteric Drug: Methacycline

  • Kin Y. Tam

Abstract.

 A multiwavelength spectrophotometric method developed previously for determining the microconstants of diprotic compounds, has been extended to resolve the micro-equilibria of a triprotic amphoteric drug, methacycline. The proposed method based on the shifts in ultra-violet absorption spectra of the compound obtained from methanol-water mixtures to deduce the unknown tautomeric ratios and microconstants. Using this new approach, the tautomeric ratios and the microconstants of methacycline were successfully determined.

Key words: Amphoteric drugs; microconstants; tautomeric ratio; kz method; methacycline 

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Copyright information

© Springer-Verlag Wien 2001

Authors and Affiliations

  • Kin Y. Tam
    • 1
  1. 1.Sirius Analytical Instruments Ltd., Riverside, Forest Row Business Park, Forest Row, East Sussex, RH18 5DW, UKGB

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