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Efficient porphyrin integrated UiO-66 probes for ratiometric fluorescence sensing of antibiotic residues in milk

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Abstract

Dual-emissive fluorescence probes were designed by integrating porphyrin into the frameworks of UiO-66 for ratiometric fluorescence sensing of amoxicillin (AMX). Porphyrin integrated UiO-66 showed dual emission in the blue and red region. AMX resulted in the quenching of blue fluorescence component, attributable to the charge neutralization and hydrogen bonds induced energy transfer. AMX was detected using (F438/F654) as output signals. Two linear relationships were observed (from 10 to 1000 nM and 1 to 100 µM), with a limit of detection of 27 nM. The porphyrin integrated UiO-66 probe was used to detect AMX in practical samples. This work widens the road for the development of dual/multiple emissive fluorescence sensors for analytical applications, providing materials and theoretical supporting for food, environmental, and human safety.

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Funding

This work was financially supported by the National Natural Science Foundation of China (22175052), Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province (B2021201038), Central Government Guided Local Science and Technology Development Fund (Hebei, 236Z0602G), High level Talent Funding Project of Hebei Province (C20231052), and Foundation of President of Hebei University (XZJJ202211), Innovation Training Program Project for College Students (2023138).

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Authors and Affiliations

  1. State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Analytical Science and Technology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, College of Chemistry & Materials Science, Hebei University, Baoding, 071002, China

    Jinzhu Ma, Yu-e Shi, Qian Song & Zhenguang Wang

  2. Department of PET/CT Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 25000, China

    Shufang Kou

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  1. Jinzhu Ma
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Correspondence to Yu-e Shi, Shufang Kou or Zhenguang Wang.

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Ma, J., Shi, Ye., Song, Q. et al. Efficient porphyrin integrated UiO-66 probes for ratiometric fluorescence sensing of antibiotic residues in milk. Microchim Acta 191, 304 (2024). https://doi.org/10.1007/s00604-024-06391-4

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