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In situ anchored ternary hierarchical hybrid nickel@cobaltous sulfide on poly(3,4-ethylenedioxythiophene)-reduced graphene oxide for highly efficient non-enzymatic glucose sensing

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Abstract

A ternary hierarchical hybrid Ni@CoxSy/poly(3,4-ethylenedioxythiophene)-reduced graphene oxide (Ni@CoxSy/PEDOT-rGO) is rationally designed and in situ facilely synthesized as electrocatalyst to construct a binder-free sensing platform for non-enzymatic glucose monitoring through traditional electrodeposition procedure. The as-prepared Ni@CoxSy/PEDOT-rGO presents unique hierarchical structure and multiple valence states as well as strong and robust adhesion between Ni@CoxSy/PEDOT-rGO and GCE. Profiting from the aforementioned merits, the sensing platform constructed under optimal conditions achieved a wide detection range (0.2 μM ~ 2.0 mM) with high sensitivity (1546.32 μA cm–2 mM–1), a rapid response time (5 s), an ultralow detection limit (0.094 μM), superior anti-interference performance, excellent reproducibility and considerable stability. Furthermore, the sensor demonstrates an acceptable accuracy and appreciable recoveries ranging from 90.0 to 102.0% with less than 3.98% RSD in human blood serum samples, indicating the prospect of the sensor for the real samples analysis. It will provide a strategy to rationally design and fabricate ternary hierarchical hybrid as nanozyme for glucose assay.

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Funding

The work reported here was supported by the National Natural Science Foundation of China under Grant No. 52072196, 52002199, 52002200, 52102106, 52202262; Major Basic Research Program of Natural Science Foundation of Shandong Province under Grant No. ZR2020ZD09; the Natural Science Foundation of Shandong Province under Grant No. ZR2020QE063; the Innovation and Technology Program of Shandong Province under Grant No. 2020KJA004, and the Taishan Scholars Program of Shandong Province under No. ts201511034; and Qingdao University of Science and Technology 2023 college students’ innovation and entrepreneurship training program under Grant No. 202310426320, X202310426152. We express our grateful thanks to them for their financial support.

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Authors and Affiliations

  1. College of Chemical Engineering, State Key Laboratory Base of Eco-Chemical Engineering, Qingdao University of Science and Technology, Shandong Province, Qingdao, 266042, China

    Liying Sheng, Licheng Zhu & Kexin Liu

  2. College of Materials Science and Engineering, Qingdao University of Science and Technology, Shandong Province, Qingdao, 266042, China

    Hongtao Tan & Zhenjiang Li

  3. College of Chemistry and Molecular Engineering, Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, State Key Laboratory Base of Eco-Chemical Engineering, Qingdao University of Science and Technology, Shandong Province, Qingdao, 266042, China

    Alan Meng

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  1. Liying Sheng
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Sheng, L., Tan, H., Zhu, L. et al. In situ anchored ternary hierarchical hybrid nickel@cobaltous sulfide on poly(3,4-ethylenedioxythiophene)-reduced graphene oxide for highly efficient non-enzymatic glucose sensing. Microchim Acta 191, 267 (2024). https://doi.org/10.1007/s00604-024-06317-0

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