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CuCo2O4 nanoneedle arrays growth on carbon cloth as a non-enzymatic electrochemical sensor with low detection limit ketoprofen recognition

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Abstract

An electrochemical sensor for detecting ketoprofen was constructed by in-situ grown copper cobaltate (CuCo2O4) nanoneedle arrays on a carbon cloth (CC) substrate. The resulting porous nanoneedle arrays not only expose numerous electrochemically active sites but also significantly enhance the electrochemical apparent active area and current transmission efficiency. By leveraging its electrochemical properties, the sensor achieves an impressive detection limit for ketoprofen of 0.7 pM, with a linear range spanning from 2 pM ~ 2 µM. Furthermore, the sensor exhibits remarkable reproducibility, anti-interference capabilities, and stability. Notably, the developed sensor also performed ketoprofen detection on real samples (including drug formulations and wastewater) and demonstrated excellent recognition ability. These exceptional performances can be attributed to the direct growth of CuCo2O4 nanoneedle arrays on the CC substrate, which facilitates a robust electrical connection, provides abundant electrocatalytic active sites, and expands the apparent active area. Consequently, these improvements contribute to the efficient trace detection capabilities of the ketoprofen sensor.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21771060 and 61271126), the International Science & Technology Cooperation Program of China (2016YFE0115100), Program for Science and Technology Project of Heilongjiang Province (JQ2021B002), Environmental Protection Department Program of Heilongjiang Province (HST2022DQ006), Basic Research Business Fees of Colleges and Universities in Heilongjiang Province (2022-KYYWF-1059), Reform and Development Fund Project of Local University supported by the Central Government, Heilongjiang Touyan Innovation Team Program.

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  1. Key Laboratory of Functional Inorganic Material Chemistry, School of Chemistry and Materials Science, Ministry of Education, Heilongjiang University, Harbin, 150080, China

    Yan Liu, Yuying Xin, Xin Wang, Xianfa Zhang, Yingming Xu, Xiaoli Cheng, Shan Gao & Lihua Huo

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  1. Yan Liu
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  2. Yuying Xin
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Correspondence to Xianfa Zhang or Lihua Huo.

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Liu, Y., Xin, Y., Wang, X. et al. CuCo2O4 nanoneedle arrays growth on carbon cloth as a non-enzymatic electrochemical sensor with low detection limit ketoprofen recognition. Microchim Acta 191, 218 (2024). https://doi.org/10.1007/s00604-024-06299-z

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