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Development of highly sensitive electrochemical immunosensor using PPy-MoS2-based nanocomposites modified with 90 MeV C6+ ion beams

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Abstract

The evaluation of electrochemical sensing activity of hydrothermally derived PPy-MoS2-based nanocomposites subjected to 90 MeV C6+ ion beam with fluence ranging, 1.0 × 1010–1.0 × 1013 ions/cm2, is reported. Cross-linking, chain scissioning, and ion track formation could occur in the irradiated systems, as revealed from Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FE-SEM) studies. Electrochemical studies, viz., cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were performed in 0.1 M phosphate buffer solution (PBS) containing 5 mM K3[Fe(CN)6] as redox probe. High redox activity, lower charge transfer resistance (Rct = 490 Ω) and larger electroactive area (A = 0.4485 cm2) were obtained in case of the composite system irradiated with a fluence of 3.5 × 1011 ions/cm2. Immunosensor fabrication was executed via immobilization of mouse IgG over the pristine and post-irradiated electrodes. Afterwards, differential pulse voltammetry (DPV) was performed within the potential window − 0.2 to + 0.6 V (vs. Ag/AgCl) for the detection of specific analyte. Noticeably, the electrode system irradiated with a fluence of 3.5 × 1011 ions/cm2 is characterized by a lower limit of detection (LOD) of 0.203 nM and a higher sensitivity value of 10.0 µA mL ng−1 cm−2. The energetic particle irradiation at a modest fluence can offer beneficial effects to the PPy-MoS2-based nanohybrid system providing immense scope as advanced electrochemical biosensor.

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Acknowledgements

We would like to express our sincere appreciation to SAIC, Tezpur University, as well as UGC-SAP DRS II and DST-FIST programs of the Department of Physics, Tezpur University, for their valuable support in terms of providing resources, facilitating the execution of ideas, and ensuring the successful implementation of this project.

Funding

This study received financial support from the IUAC, New Delhi, through the UFR-66303/2019 project.

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  1. Nanoscience and Soft-Matter Laboratory, Department of Physics, Tezpur University, PO: Napaam, Tezpur-784 028, Assam, India

    Ankush Medhi & Dambarudhar Mohanta

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  1. Ankush Medhi
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Correspondence to Dambarudhar Mohanta.

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Medhi, A., Mohanta, D. Development of highly sensitive electrochemical immunosensor using PPy-MoS2-based nanocomposites modified with 90 MeV C6+ ion beams. Microchim Acta 191, 166 (2024). https://doi.org/10.1007/s00604-024-06210-w

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