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Core–shell “loading-type” nanomaterials enabling glucometer readout for portable and sensitive detection of p-aminophenol in real samples

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Abstract

A one-target-many-trigger signal model sensing strategy is proposed for quickly, sensitive and on-site detection of the environmental pollutant p-aminophenol (PAP) by use of a commercial personal glucose meter (PGM) for signal readout with the core–shell “loading-type” nanomaterial MSNs@MnO2 as amplifiable nanoprobes. In this design, the mesoporous silica nanoparticles (MSNs) nanocontainer with entrapped signal molecule glucose is coated with redoxable manganese dioxide (MnO2) nanosheets to form the amplifiable nanoprobes (Glu-MSNs@MnO2). When encountered with PAP, the redox reaction between the MnO2 and PAP can induce the degradation of the outer layer of MSNs@MnO2, liberating multiple copies of the loaded glucose to light up the PGM signal. Owing to the high loading capability of nanocarriers, a “one-to-many” relationship exists between the target and the signal molecule glucose, which can generate adequate signal outputs to achieve the requirement of on-site determination of environmental pollutants. Taking advantage of this amplification mode, the developed PAP assay owns a dynamic linear range of 10.0–400 μM with a detection limit of 2.78 μM and provides good practical application performance with above 96.7 ± 4.83% recovery in environmental water and soil samples. Therefore, the PGM-based amplifiable sensor for PAP proposed can accommodate these requirements of environment monitoring and has promising potential for evaluating pollutants in real environmental samples.

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Funding

This work was supported by the National Key Research and Development Program of China (2018YFA0901300), the National Natural Science Foundation of China (Grant No. 22078149), the Natural Science Foundation of Jiangsu Province (No. BK20220002), and the Key Research and Development Program of Jiangsu Province (No. BE2023360).

the National Key Research and Development Program of China,2018YFA0901300,Jing jing Xie,National Natural Science Foundation of China,22078149,Jing jing Xie,Natural Science Foundation of Jiangsu Province,BK20220002,Jing jing Xie,Jiangsu Provincial Key Research and Development Program,BE2023360,Jing jing Xie

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Authors and Affiliations

  1. State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, People’s Republic of China

    Xiang-Ling Li, Lei Zhao, Zi-Heng Wang, Tian-Shun Song & Jing Jing Xie

  2. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People’s Republic of China

    Xiang-Ling Li, Lei Zhao, Zi-Heng Wang, Tian-Shun Song & Jing Jing Xie

  3. Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, People’s Republic of China

    Ting Guo

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Xiang-Ling Li: conceptualization; methodology; formal analysis; investigation; writing—original draft; visualization. Lei Zhao: investigation; writing—review and editing. Zi-Heng Wang: validation; writing—review and editing. Tian-shun Song: writing—review and editing. Ting Guo: conceptualization; writing—review and editing. Jing Jing Xie: conceptualization; project administration; funding acquisition; supervision.

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Correspondence to Ting Guo or Jing Jing Xie.

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Li, XL., Zhao, L., Wang, ZH. et al. Core–shell “loading-type” nanomaterials enabling glucometer readout for portable and sensitive detection of p-aminophenol in real samples. Microchim Acta 191, 127 (2024). https://doi.org/10.1007/s00604-024-06204-8

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