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A flexible semiconductor SERS substrate by in situ growth of tightly aligned TiO2 for in situ detection of antibiotic residues

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Abstract

Semiconductor materials have become a competitive candidate for surface-enhanced Raman scattering (SERS) substrate. However, powdered semiconductors are difficult to execute a fast in situ detection for trace analytes. Here, we developed a new flexible semiconductor SERS substrate by in situ densely growing anatase TiO2 nanoparticles on the surface of cotton fabric through a filtration-hydrothermal method, in which TiO2 exhibits excellent controllability in size and distribution by regulating the ratio of water to alcohol in synthesis and the number of filtration-hydrothermal repetitive cycle. Cotton fabric/TiO2 (Cot/TiO2) substrate exhibits a high SERS activity and excellent spectral repeatability. The developed substrate has an ultra-high stability that can withstand long-term preservation; it can even resist the corrosions of strong acid and alkali, as well as high temperature up to 100 °C and low temperature down to − 20 °C. The flexible substrate can be used to carry out a rapid in situ detection for quinolone antibiotic (enrofloxacin and enoxacin) residues on the fish body surface by using a simple swabbing method, with high quantitative detection potential (up to an order of magnitude of 10−7 M), and even for the simultaneous detection of both drug residues. The flexible substrate also exhibits an excellent recyclability up to 6 recycles in the actual SERS detection.

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Funding

The research was supported by the National Natural Science Foundation of China (21804054, 21773080), the Natural Science Foundation of Heilongjiang Province of China for Distinguished Young Scholars (JQ2019B002), and the Scientific Research Project of Qiqihar University (130412223001, 130412223002).

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Authors and Affiliations

  1. College of Pharmacy, Jiamusi University, Jiamusi, 154007, China

    Kaiwei Li, Han Jiang, Liying Wang, Rui Wang, Xuewei Zhang, Libin Yang & Xin Jiang

  2. College of Chemistry and Chemical Engineering, Technology Innovation Center of Industrial Hemp for State Market Regulation, Qiqihar University, Qiqihar, 161006, China

    Libin Yang & Xin Jiang

  3. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China

    Wei Song & Bing Zhao

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  1. Kaiwei Li
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Li, K., Jiang, H., Wang, L. et al. A flexible semiconductor SERS substrate by in situ growth of tightly aligned TiO2 for in situ detection of antibiotic residues. Microchim Acta 191, 113 (2024). https://doi.org/10.1007/s00604-024-06193-8

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