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Detection of pioglitazone based on dual-emission ratiometric fluorescence probe consisting of ZIF8 and to L-ASC-AuNP/DA nanoparticles

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Abstract

A simple and sensitive dual-emission ratiometric fluorescent probe was developed using zeolitic imidazolate framework 8 (ZIF8) and L-ascorbic acid Au-doped dopamine nanoparticles (ZIF8/L-ASC-AuNP/DA NP) for the determination of pioglitazone (Pio), an oral hypoglycemic agent and insulin sensitizer, in real samples. The prepared system was based on the Pio-enhanced dual-emission intensity of ZIF8/L-ASC-AuNP/DA NP. The potential impact of various parameters on the system’s emission intensity was tested. According to the findings, there is a strong linear correlation between the system's turn-on fluorescence intensity and Pio concentrations in the range 0.3 nM to 30.0 μM. The obtained value for the limit of detection (LOD) was 0.14 nM. In addition, the intra- and inter-day accuracy of the nanoprobe was studied and the findings revealed satisfactory precision and accuracy of the system. The short-term and freeze-thaw stability of Pio in plasma samples was evaluated and the results indicated the high stability of the developed nanoprobe under the test conditions. Pio was accurately detected in human plasma samples under ideal conditions with analytical recoveries in the range 86.0 − 109.3%. The results showed that the devised probe may be employed as an easy, sensitive, and precise approach for detecting Pio in real samples.

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Funding

This work was supported by the University of Tabriz and the Pharmaceutical Analysis Research Center of Tabriz University of Medical Sciences, Tabriz, Iran. It is declared that all ethical issues were regarded during working with biological samples.

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Authors and Affiliations

  1. Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, 5166616471, Iran

    Masoud Gazizadeh & Gholamreza Dehghan

  2. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 51656-65811, Iran

    Jafar Soleymani

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  1. Masoud Gazizadeh
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  2. Gholamreza Dehghan
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  3. Jafar Soleymani
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Correspondence to Gholamreza Dehghan or Jafar Soleymani.

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Gazizadeh, M., Dehghan, G. & Soleymani, J. Detection of pioglitazone based on dual-emission ratiometric fluorescence probe consisting of ZIF8 and to L-ASC-AuNP/DA nanoparticles. Microchim Acta 191, 30 (2024). https://doi.org/10.1007/s00604-023-06082-6

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  • DOI: https://doi.org/10.1007/s00604-023-06082-6

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