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Ingenious fabrication of bamboo leaf-like ferric vanadate intertwined multi-walled carbon nanotubes nanocomposite as a sensitive sensor for determination of uric acid in fetal bovine serum

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Abstract

A novel nanocomposite material, ferric vanadate intertwined multi-walled carbon nanotubes (FeV/MWCNTs), has been designed which was drop-coated onto a glassy carbon electrode (GCE). The constructed sensor was used for the sensitive determination of uric acid (UA) in fetal bovine serum (FBS) and human serum (HS). A series of characterization and electrochemical tests showed that the ultrasound-assisted assembly of FeV with MWCNTs not only overcame the disadvantages of low conductivity and easy (unwanted) aggregation, but also avoided the decrease in effective surface area due to the severe aggregation of each individual raw material. The fabricated FeV/MWCNTs nanocomposites exhibited higher conductivity, larger effective surface area, and better electrocatalytic activity. In addition, under optimized conditions, the developed electrochemical sensor FeV/MWCNTs/GCE has a lower limit of detection (LOD, 0.05 µM; Ep = 0.268 V vs. Ag/AgCl) and wider linear range (0.20–100 µM), which can satisfy the criteria of trace UA detection. The results of UA determination in FBS (recovery = 95.5–103%; RSD ≤ 3.1%) and HS (recovery = 95.5–103%; RSD ≤ 4.3%) further validated the feasibility of FeV/MWCNTs-based electrochemical sensors for the determination of UA in biological fluids.

Highlights

  • Effects of hydrothermal conditions on physicochemical properties of FeV NPs were investigated.

  • The assembly of FeV NPs and MWCNTs was performed.

  • FeV/MWCNTs/GCE exhibited high sensitivity for electrochemical detection of UA.

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Acknowledgements

We gratefully acknowledge the financial support from Hunan Provincial Science Fund for Distinguished Young Scholars (No. 2016JJ1023).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan, China

    Shuang-Ning Li, Ya You, Xin-Yu Jiang & Jin-Gang Yu

  2. Chengdu Advanced Metal Materials Industry Technology Research Institute Co., Ltd., Chengdu, 610300, Sichuan, China

    Bo Liu

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Li, SN., You, Y., Liu, B. et al. Ingenious fabrication of bamboo leaf-like ferric vanadate intertwined multi-walled carbon nanotubes nanocomposite as a sensitive sensor for determination of uric acid in fetal bovine serum. Microchim Acta 190, 439 (2023). https://doi.org/10.1007/s00604-023-06019-z

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