Abstract
The measurement of food contaminants faces a great challenge owing to the increasing demand for safe food, increasing consumption of fast food, and rapidly changing patterns of human consumption. As different types of contaminants in food products can pose different levels of threat to human health, it is desirable to develop specific and rapid methods for their identification and quantification. During the past few years, metal-organic framework (MOF)–based materials have been extensively explored in the development of food safety sensors. MOFs are porous crystalline materials with tunable composition, dynamic porosity, and facile surface functionalization. The construction of high-performance biosensors for a range of applications (e.g., food safety, environmental monitoring, and biochemical diagnostics) can thus be promoted through the synergistic combination of MOFs with aptamers. Accordingly, this review article delineates recent innovations achieved for the aptamer-functionalized MOFs toward the detection of food contaminants. First, we describe the basic concepts involved in the detection of food contaminants in terms of the advantages and disadvantages of the commonly used analytical methods (e.g., DNA-based methods (PCR/real-time PCR/multiplex PCR/digital PCR) and protein-based methods (enzyme-linked immunosorbent assay/immunochromatography assay/immunosensor/mass spectrometry). Afterward, the progress in aptamer-functionalized MOF biosensors is discussed with respect to the sensing mechanisms (e.g., the role of MOFs as signal probes and carriers for loading signal probes) along with their performance evaluation (e.g., in terms of sensitivity). We finally discuss challenges and opportunities associated with the development of aptamer-functionalized MOFs for the measurement of food contaminants.
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Rather IA et al (2017) The sources of chemical contaminants in food and their health implications. Front Pharmacol 8:830
Rodriguez RS et al (2020) Sensing food contaminants: advances in analytical methods and techniques. Anal Chem 93(1):23–40
Duan N et al (2016) Advances in aptasensors for the detection of food contaminants. Analyst 141(13):3942–3961
Kuswandi B, Futra D, Heng L (2017) Nanosensors for the detection of food contaminants. In: Nanotechnology applications in food. Elsevier, pp 307–333
Xu H et al (2017) Residue analysis of tetracyclines in milk by HPLC coupled with hollow fiber membranes-based dynamic liquid-liquid micro-extraction. Food Chem 232:198–202
Song E et al (2015) Multi-color quantum dot-based fluorescence immunoassay array for simultaneous visual detection of multiple antibiotic residues in milk. Biosens Bioelectron 72:320–325
Weston M, Geng S, Chandrawati R (2021) Food sensors: challenges and opportunities. Adv Mater Technol 6(5):2001242
Elfadil D et al (2021) Molecularly imprinted polymers combined with electrochemical sensors for food contaminants analysis. Molecules 26(15):4607
Sharma R et al (2015) Recent advances in nanoparticle based aptasensors for food contaminants. Biosens Bioelectron 74:612–627
Zhang Z et al (2021) Metal–organic frameworks (MOFs) based chemosensors/biosensors for analysis of food contaminants. Trends Food Sci Technol 118:569–588
Naghdi S et al (2023) Recent advances in application of metal-organic frameworks (MOFs) as adsorbent and catalyst in removal of persistent organic pollutants (POPs). J Hazard Mater 442:130127
Khoshbin Z et al (2022) Metal organic frameworks as advanced functional materials for aptasensor design. Spectrochim Acta - Part A: Mol Biomol Spectrosc 2022:276
Duan N et al (2020) A visual and sensitive detection of Escherichia coli based on aptamer and peroxidase-like mimics of copper-metal organic framework nanoparticles. Food Anal Methods 13(7):1433–1441
Khoshbin Z et al (2022) A fluorescence imaging-supported aptasensor for sensitive monitoring of cadmium pollutant in diverse samples: a critical role of metal organic frameworks. Talanta 246:123514
Li M et al (2021) Recent advances in metal-organic framework-based electrochemical biosensing applications. Front Bioeng Biotechnol 9:2296–4185
Xing S, Cheng S, Tan M (2023) Multi-emitter metal-organic frameworks as ratiometric luminescent sensors for food contamination and spoilage detection. Crit Rev Food Sci Nutr 1–17
Song Y et al (2021) A label-free enrofloxacin electrochemical aptasensor constructed by a semiconducting CoNi-based metal–organic framework (MOF). Electrochim Acta 368:137609
Falsafi M et al (2021) Aptamer targeted red blood cell membrane-coated porphyrinic copper-based MOF for guided photochemotherapy against metastatic breast cancer. Micropor Mesopor Mat 325:111337
González CMO et al (2021) Synthesis and applications of MOF-derived nanohybrids: a review. Mater Today: Proc 46:3018–3029
Helal A et al (2017) Multivariate metal-organic frameworks. Natl Sci Rev 4(3):296–298
Jahangiri-Dehaghani F, Zare HR, Shekari Z (2020) Measurement of aflatoxin M1 in powder and pasteurized milk samples by using a label–free electrochemical aptasensor based on platinum nanoparticles loaded on Fe–based metal–organic frameworks. Food Chem 310:125820
Howarth AJ et al (2016) Chemical, thermal and mechanical stabilities of metal–organic frameworks. Nat Rev Mater 1(3):1–15
Vickers NJ (2017) Animal communication: when i’m calling you, will you answer too? Curr Biol 27(14):R713–R715
Mishra GK, Sharma V, Mishra RK (2018) Electrochemical aptasensors for food and environmental safeguarding: a review. Biosensors 8(2):28
Omarova A et al (2022) A review on preparation methods and applications of metal–organic framework-based solid-phase microextraction coatings. Microchem J 175:107147
Kim D-M et al (2021) Recent advances in micro/nanomaterial-based aptamer selection strategies. Molecules 26(17):5187
Wang K et al (2015) Highly sensitive and specific colorimetric detection of cancer cells via dual-aptamer target binding strategy. Biosens Bioelectron 73:1–6
Stewart KD, Tan W, Park JY (2019) Aptamer selection for detecting molecular target using cell-SELEX (Systematic Evolution of Ligands by Exponential Enrichment) technology. In: Theranostics. Springer, pp 223–241
Zhang K et al (2020) Application of multiplexed aptasensors in food contaminants detection. ACS sensors 5(12):3721–3738
Sun S et al (2023) Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle. Bioact Mater 20:166–178
Jia Y et al (2020) A metal-organic framework/aptamer system as a fluorescent biosensor for determination of aflatoxin B1 in food samples. Talanta 219:121342
Jahangiri-Dehaghani F, Zare HR, Shekari Z (2022) A non-label electrochemical aptasensor based on Cu metal–organic framework to measure aflatoxin B1 in wheat flour. Food Anal Methods 15(1):192–202
Khoshbin Z et al (2022) Metal organic frameworks as advanced functional materials for aptasensor design. Spectrochim Acta A Mol Biomol Spectrosc 276:121251
Karimzadeh Z et al (2022) Aptamer-functionalized metal organic frameworks as an emerging nanoprobe in the food safety field: promising development opportunities and translational challenges. TrAC Trends Anal Chem 152:116622
Randhawa G, Singh M, Sood P (2016) DNA-based methods for detection of genetically modified events in food and supply chain. Curr Sci 110(6):1000–1009
Alarcon CM et al (2018) Application of DNA-and protein-based detection methods in agricultural biotechnology. J Agric Food Chem 67(4):1019–1028
Madesis P et al (2014) Advances of DNA-based methods for tracing the botanical origin of food products. Food Res Int 60:163–172
Chen J-Q et al (2017) PCR-based methodologies for detection and characterization of Listeria monocytogenes and Listeria ivanovii in foods and environmental sources. Food Sci Human Wellness 6(2):39–59
Kojabad AA et al (2021) Droplet digital PCR of viral DNA/RNA, current progress, challenges, and future perspectives. J Med Virol 93(7):4182–4197
Umesha S, Manukumar H (2018) Advanced molecular diagnostic techniques for detection of food-borne pathogens: current applications and future challenges. Crit Rev Food Sci Nutr 58(1):84–104
Chapela M-J, Garrido-Maestu A, Cabado AG (2015) Detection of foodborne pathogens by qPCR: a practical approach for food industry applications. Cogent Food Agric 1(1):1013771
Garrido-Maestu A, Tomás Fornés D, Prado Rodríguez M (2019) The use of multiplex real-time PCR for the simultaneous detection of foodborne bacterial pathogens. In: Foodborne Bacterial Pathogens. Springer, pp 35–45
Tao J et al (2020) A multiplex PCR assay with a common primer for the detection of eleven foodborne pathogens. J Food Sci 85(3):744–754
McMahon TC et al (2017) Multiplexed single intact cell droplet digital PCR (MuSIC ddPCR) method for specific detection of enterohemorrhagic E. coli (EHEC) in food enrichment cultures. Front Microbiol 8:332
Hunter ME et al (2017) Detection limits of quantitative and digital PCR assays and their influence in presence–absence surveys of environmental DNA. Mol Ecol Resour 17(2):221–229
Bootz F et al (2003) Comparison of the sensitivity of in vivo antibody production tests with in vitro PCR-based methods to detect infectious contamination of biological materials. Lab Anim 37(4):341–351
Cheng C-M et al (2008) Rapid detection of Salmonella in foods using real-time PCR. J Food Prot 71(12):2436–2441
Tevell Åberg A, Björnstad K, Hedeland M (2013) Mass spectrometric detection of protein-based toxins. Biosecur Bioterror: Biodefense Strategy, Practice, and Science 11(S1):S215–S226
Xiong Y et al (2020) Emerging strategies to enhance the sensitivity of competitive ELISA for detection of chemical contaminants in food samples. TrAC Trends Anal Chem 126:115861
Wu L et al (2019) Application of nano-ELISA in food analysis: recent advances and challenges. TrAC Trends Anal Chem 113:140–156
Nielen M et al (2011) Desorption electrospray ionization mass spectrometry in the analysis of chemical food contaminants in food. TrAC Trends Anal Chem 30(2):165–180
Xiong Y et al (2018) Plasmonic ELISA based on enzyme-assisted etching of Au nanorods for the highly sensitive detection of aflatoxin B1 in corn samples. Sens Actuators B 267:320–327
Anfossi L et al (2013) Lateral-flow immunoassays for mycotoxins and phycotoxins: a review. Anal Bioanal Chem 405(2):467–480
Dzantiev BB et al (2014) Immunochromatographic methods in food analysis. TrAC Trends Anal Chem 55:81–93
Wu Y et al (2021) Ensuring food safety using fluorescent nanoparticles-based immunochromatographic test strips. Trends Food Sci Technol 118:658–678
Pilolli R, Monaci L, Visconti A (2013) Advances in biosensor development based on integrating nanotechnology and applied to food-allergen management. TrAC Trends Anal Chem 47:12–26
Piro B et al (2016) Comparison of electrochemical immunosensors and aptasensors for detection of small organic molecules in environment, Food Safety, Clinical and Public Security. Biosensors 6(1):7
Aranda PR et al (2018) Nanomaterials in fluorescent laser-based immunosensors: review and applications. Microchem J 141:308–323
Jia M et al (2021) Recent advances on immunosensors for mycotoxins in foods and other commodities. TrAC Trends Anal Chem 136:116193
Dong Y et al (2014) Aptamer and its potential applications for food safety. Crit Rev Food Sci Nutr 54(12):1548–1561
Wang T et al (2019) Three decades of nucleic acid aptamer technologies: lessons learned, progress and opportunities on aptamer development. Biotechnol Adv 37(1):28–50
Lv M et al (2021) Aptamer-functionalized metal-organic frameworks (MOFs) for biosensing. Biosens Bioelectron 176:112947
Paniel N et al (2017) Selection of DNA aptamers against penicillin G using Capture-SELEX for the development of an impedimetric sensor. Talanta 162:232–240
Guo Z et al (2022) Determination of lead in food by surface-enhanced Raman spectroscopy with aptamer regulating gold nanoparticles reduction. Food Control 132:108498
Yan C et al (2018) Aptamer-mediated colorimetric method for rapid and sensitive detection of chloramphenicol in food. Food Chem 260:208–212
Li F et al (2019) Electrochemical aptamer-based sensors for food and water analysis: a review. Anal Chim Acta 1051:1–23
Xie M et al (2022) Recent advances in aptamer-based optical and electrochemical biosensors for detection of pesticides and veterinary drugs. Food Control 131:108399
Zhang Y, Lai BS, Juhas M (2019) Recent advances in aptamer discovery and applications. Molecules 24(5):941
Majdinasab M, Hayat A, Marty JL (2018) Aptamer-based assays and aptasensors for detection of pathogenic bacteria in food samples. TrAC Trends Anal Chem 107:60–77
Zhou Y et al (2019) Determination of malachite green in fish by a modified MOF-based electrochemical sensor. Food Anal Methods 12(5):1246–1254
Janiak C, Vieth JK (2010) MOFs, MILs and more: concepts, properties and applications for porous coordination networks (PCNs). New J Chem 34(11):2366–2388
Safaei M et al (2019) A review on metal-organic frameworks: synthesis and applications. TrAC Trends Anal Chem 118:401–425
Gangu KK et al (2016) A review on contemporary metal–organic framework materials. Inorg Chim Acta 446:61–74
Kukkar P et al (2021) Recent advances in the synthesis techniques for zeolitic imidazolate frameworks and their sensing applications. Coord Chem Rev 446:214109
Burnett BJ, Barron PM, Choe W (2012) Recent advances in porphyrinic metal–organic frameworks: materials design, synthetic strategies, and emerging applications. CrystEngComm 14(11):3839–3846
Kumar P, Deep A, Kim K-H (2015) Metal organic frameworks for sensing applications. TrAC Trends Anal Chem 73:39–53
Wang T et al (2018) Self-sacrificial template synthesis of mixed-valence-state cobalt nanomaterials with high catalytic activities for colorimetric detection of glutathione. Sens Actuators B 254:329–336
Zhou H-C, Long JR, Yaghi OM (2012) Introduction to metal–organic frameworks. ACS Publications 112(2):673–674
Liu Q et al (2019) Metal-organic framework-based fluorescent sensing of tetracycline-type antibiotics applicable to environmental and food analysis. Analyst 144(6):1916–1922
Liu Y et al (2019) Strategies to fabricate metal–organic framework (MOF)-based luminescent sensing platforms. J Mater Chem C 7(35):10743–10763
Song J et al (2022) Novel Fe-based metal–organic framework (MOF) modified carbon nanofiber as a highly selective and sensitive electrochemical sensor for tetracycline detection. Chem Eng J 427:130913
Mu Z et al (2022) A new electrochemical aptasensor for ultrasensitive detection of endotoxin using Fe-MOF and AgNPs decorated PN-CNTs as signal enhanced indicator. Appl Surf Sci 573:151601
Yang Z et al (2022) Metal-organic framework-based sensors for the detection of toxins and foodborne pathogens. Food Control 133:108684
Yin Z et al (2019) Recent advances in post-synthetic modification of metal–organic frameworks: new types and tandem reactions. Coord Chem Rev 378:500–512
Xiang Z et al (2014) An amino group functionalized metal–organic framework as a luminescent probe for highly selective sensing of Fe 3+ ions. J Mater Chem A 2(21):7662–7665
Lv M et al (2021) Aptamer-functionalized metal-organic frameworks (MOFs) for biosensing. Biosens Bioelectron 176:112947
Wang Q, Sun J, Wei D (2022) Two-dimensional metal-organic frameworks and covalent organic frameworks. Chin J Chem 40(11):1359–1385
Rojas S, Horcajada P (2020) Metal–organic frameworks for the removal of emerging organic contaminants in water. Chem Rev 120(16):8378–8415
Liu B et al (2022) Metal-organic frameworks functionalized with nucleic acids and amino acids for structure-and function-specific applications: a tutorial review. Chem Eng J 428:131118
Chen G et al (2017) Design of porous/hollow structured ceria by partial thermal decomposition of Ce-MOF and selective etching. ACS Appl Mater Interfaces 9(45):39594–39601
He C et al (2014) Nanoscale metal–organic frameworks for the co-delivery of cisplatin and pooled siRNAs to enhance therapeutic efficacy in drug-resistant ovarian cancer cells. J Am Chem Soc 136(14):5181–5184
Ling P et al (2015) Porphyrin-encapsulated metal–organic frameworks as mimetic catalysts for electrochemical DNA sensing via allosteric switch of hairpin DNA. Anal Chem 87(7):3957–3963
Tolentino MQ et al (2020) Controlled release of small molecules and proteins from DNA-surfactant stabilized metal organic frameworks. J Mater Chem B 8(26):5627–5635
Liu B et al (2022) Metal-organic frameworks functionalized with nucleic acids and amino acids for structure- and function-specific applications: a tutorial review. Chem Eng J 428:131118
Chang J et al (2019) Nucleic acid-functionalized metal–organic framework-based homogeneous electrochemical biosensor for simultaneous detection of multiple tumor biomarkers. Anal Chem 91(5):3604–3610
Wang XZ et al (2020) Solvothermal and ultrasonic preparation of two unique cluster-based Lu and Y coordination materials: metal–organic framework-based ratiometric fluorescent biosensor for an ornidazole and ronidazole and sensing platform for a biomarker of amoeba liver abscess. Inorg Chem 59(5):2910–2922
Wang P et al (2022) One-step simultaneous quantitative detection of three pesticides based on bimetallic organic framework nanomaterials and aptamers. Anal Sci 38(2):299–305
Shahrokhian S, Ranjbar S (2018) Aptamer immobilization on amino-functionalized metal–organic frameworks: an ultrasensitive platform for the electrochemical diagnostic of Escherichia coli O157:H7. Analyst 143(13):3191–3201
Dai G et al (2019) Electrochemical determination of Salmonella typhimurium by using aptamer-loaded gold nanoparticles and a composite prepared from a metal-organic framework (type UiO-67) and graphene. Microchimica Acta 186(9):620
Wang W et al (2020) A universal signal-on electrochemical assay for rapid on-site quantitation of vibrio parahaemolyticus using aptamer modified magnetic metal–organic framework and phenylboronic acid-ferrocene co-immobilized nanolabel. Anal Chim Acta 1133:128–136
Feng D et al (2019) Electrochemiluminecence nanogears aptasensor based on MIL-53(Fe)@CdS for multiplexed detection of kanamycin and neomycin. Biosens Bioelectron 129:100–106
Yao X et al (2020) A novel electrochemical aptasensor for the sensitive detection of kanamycin based on UiO-66-NH2/MCA/MWCNT@rGONR nanocomposites. Anal Methods 12(41):4967–4976
Wen J et al (2021) Ultrasensitive ECL aptasensing of kanamycin based on synergistic promotion strategy using 3,4,9,10-perylenetetracar-boxylic-L-cysteine/Au@HKUST-1. Anal Chim Acta 1180:338780
Liu X et al (2019) Novel nanoarchitecture of Co-MOF-on-TPN-COF hybrid: ultralowly sensitive bioplatform of electrochemical aptasensor toward ampicillin. Biosens Bioelectron 123:59–68
Meng X et al (2020) Sensitive detection of streptomycin in milk using a hybrid signal enhancement strategy of MOF-based bio-bar code and target recycling. Anal Chim Acta 1125:1–7
Huang S et al (2018) Electrochemical aptasensor for multi-antibiotics detection based on endonuclease and exonuclease assisted dual recycling amplification strategy. Talanta 179:28–36
Huang S et al (2019) Portable fluoride-selective electrode as signal transducer for sensitive and selective detection of trace antibiotics in complex samples. Biosens Bioelectron 128:113–121
Chen M et al (2017) A novel aptamer- metal ions- nanoscale MOF based electrochemical biocodes for multiple antibiotics detection and signal amplification. Sens Actuators B 242:1201–1209
Liu S et al (2020) A zirconium-porphyrin MOF-based ratiometric fluorescent biosensor for rapid and ultrasensitive detection of chloramphenicol. Biosens Bioelectron 149:111801
Yang Q et al (2018) A two dimensional metal–organic framework nanosheets-based fluorescence resonance energy transfer aptasensor with circular strand-replacement DNA polymerization target-triggered amplification strategy for homogenous detection of antibiotics. Anal Chim Acta 1020:1–8
Luan Q et al (2018) A multiple signal amplified colorimetric aptasensor for antibiotics measurement using DNAzyme labeled Fe-MIL-88-Pt as novel peroxidase mimic tags and CSDP target-triggered cycles. Talanta 187:27–34
Zhou N et al (2019) Construction of Ce-MOF@COF hybrid nanostructure: label-free aptasensor for the ultrasensitive detection of oxytetracycline residues in aqueous solution environments. Biosens Bioelectron 127:92–100
Chen M et al (2016) An electrochemical aptasensor for multiplex antibiotics detection based on metal ions doped nanoscale MOFs as signal tracers and RecJf exonuclease-assisted targets recycling amplification. Talanta 161:867–874
Wei P et al (2022) Coni bimetallic metal-organic frameworks and gold nanoparticles-based aptamer electrochemical sensor for enrofloxacin detection. Appl Surf Sci 604:154369
Lv L et al (2022) A “signal off” aptasensor based on AuNPs/Ni-MOF substrate-free catalyzed for detection Enrofloxacin. J Electroanal Chem 911:116251
Guo C et al (2020) Semiconducting CuxNi3- x (hexahydroxytriphenylene)2framework for electrochemical aptasensing of C6 glioma cells and epidermal growth factor receptor. J Mater Chem B 8(43):9951–9960
Zhang Y, Ren HX, Miao YB (2019) Visualization and colorimetric determination of clenbuterol in pork by using magnetic beads modified with aptamer and complementary DNA as capture probes, and G-quadruplex/hemin and DNA antibody on the metal-organic framework MIL-101(Fe) acting as a peroxidase mimic. Microchimica Acta 186(8):515
Zhang Y et al (2021) Amplified electrochemical antibiotic aptasensing based on electrochemically deposited AuNPs coordinated with PEI-functionalized Fe-based metal-organic framework. Microchimica Acta 188(8):286
Wang S et al (2019) Bimetallic cerium/copper organic framework-derived cerium and copper oxides embedded by mesoporous carbon: Label-free aptasensor for ultrasensitive tobramycin detection. Anal Chim Acta 1047:150–162
Zhou L et al (2021) A highly-enhanced electrochemiluminescence luminophore generated by a metal-organic framework-linked perylene derivative and its application for ractopamine assay. Analyst 146(6):2029–2036
Feng D et al (2020) Electrochemiluminescence aptasensor for multiple determination of Hg2+ and Pb2+ ions by using the MIL-53(Al)@CdTe-PEI modified electrode. Anal Chim Acta 1100:232–239
Salandari-Jolge N, Ensafi AA, Rezaei B (2021) Ultra-sensitive electrochemical aptasensor based on zeolitic imidazolate framework-8 derived Ag/Au core-shell nanoparticles for mercury detection in water samples. Sens Actuators B 331:129426
Xu W et al (2017) Label-free and enzyme-free strategy for sensitive electrochemical lead aptasensor by using metal-organic frameworks loaded with AgPt nanoparticles as signal probes and electrocatalytic enhancers. Electrochim Acta 251:25–31
Zhang J et al (2022) Electrochemical aptasensor for aflatoxin B1 detection using cerium dioxide nanoparticle supported on iron-porphyrinic metal–organic framework as signal probes. Microchem J 181:107716
Meng D, Gan X, Tian T (2022) An electrochemical sensing method for aflatoxin B1 detection based on Pt-coordinated titanium-based porphyrin MOF. Int J Electrochem Sci 17(2):220247
Sun Y, Zhang Y, Wang Z (2021) A “turn-on” FRET aptasensor based on the metal-organic framework-derived porous carbon and silver nanoclusters for zearalenone determination. Sens Actuators B Chem 347:130661
Hou S et al (2020) Quantum dot nanobead-based fluorescent immunochromatographic assay for simultaneous quantitative detection of fumonisin B1, dexyonivalenol, and zearalenone in grains. Food Control 117:107331
Wen X et al (2021) A multifunctional n-doped cu–mofs (N–cu–mof) nanomaterial-driven electrochemical aptasensor for sensitive detection of deoxynivalenol. Molecules 26(8):2243
Duan F et al (2022) Electrochemical aptasensing strategy based on a multivariate polymertitanium-metal-organic framework for zearalenone analysis. Food Chem 385:132654
Sun Y et al (2022) Sensitive colorimetric aptasensor based on stimuli-responsive metal-organic framework nano-container and trivalent DNAzyme for zearalenone determination in food samples. Food Chem 371:131145
Song Y et al (2021) Novel impedimetric sensing strategy for detecting ochratoxin A based on NH2-MIL-101(Fe) metal-organic framework doped with cobalt phthalocyanine nanoparticles. Food Chem 351:129248
Qiao X et al (2021) A label-free aptasensor for ochratoxin a detection with signal amplification strategies on ultrathin micron-sized 2D MOF sheets. Sens Actuators B 334:129682
Qiu W et al (2020) Specific coordination between Zr-MOF and phosphate-terminated DNA coupled with strand displacement for the construction of reusable and ultrasensitive aptasensor. Anal Chem 92(16):11332–11340
Zhao X et al (2021) A fluorescence aptasensor for the sensitive detection of T-2 toxin based on FRET by adjusting the surface electric potentials of UCNPs and MIL-101. Anal Chim Acta 1160:338450
Tan X et al (2021) A switchable and signal-amplified aptasensor based on metal organic frameworks as the quencher for turn-on detection of T-2 mycotoxin. Anal Bioanal Chem 413(26):6595–6603
Zhao Y et al (2021) Europium-based metal-organic framework containing characteristic metal chains: a novel turn-on fluorescence sensor for simultaneous high-performance detection and removal of tetracycline. Sens Actuators B 334:129610
Qiao X et al (2019) Ultrasensitive “signal-on” electrochemical aptasensor for assay of acetamiprid residues based on copper-centered metal-organic frameworks. Anal Chim Acta 1050:51–59
Su Z et al (2022) Determination of acetamiprid by fluorescence monitoring of a glycine-L-histidine copper-organic framework aptasensor. Anal Lett 55(4):529–538
Liu Q et al (2020) Magnetically controlled colorimetric aptasensor for chlorpyrifos based on copper-based metal-organic framework nanoparticles with peroxidase mimetic property. Microchimica Acta 187(9):524
Liu Q et al (2019) Fluorescent aptasensing of chlorpyrifos based on the assembly of cationic conjugated polymer-aggregated gold nanoparticles and luminescent metal–organic frameworks. Analyst 144(20):6025–6032
Li Y et al (2022) Fabrication of carbon dots@hierarchical mesoporous ZIF-8 for simultaneous ratiometric fluorescence detection and removal of tetracycline antibiotics. Sens Actuators B 358:131526
Huang S et al (2021) Diverse metal ions-doped titanium-based metal-organic frameworks as novel bioplatforms for sensitively detecting bisphenol A. Electrochim Acta 384:138403
Duan Y et al (2020) Electrochemical endotoxin aptasensor based on a metal-organic framework labeled analytical platform. Mater Sci Eng C 108:110501
Khoshbin Z et al (2022) A simple and ultrasensitive metal-organic framework-based aptasensor for fluorescence detection of ethanolamine. Spectrochim Acta A Mol Biomol Spectrosc 267:120488
Sun Y et al (2019) Ketjen black/ferrocene dual-doped MOFs and aptamer-coupling gold nanoparticles used as a novel ratiometric electrochemical aptasensor for vanillin detection. Anal Chim Acta 1083:101–109
van Elsland D, Neefjes J (2018) Bacterial infections and cancer. EMBO Rep 19(11):e46632
Reygaert WC (2018) An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiol 4(3):482–501
Váradi L et al (2017) Methods for the detection and identification of pathogenic bacteria: past, present, and future. Chem Soc Rev 46(16):4818–4832
Kumar A et al (2019) Chapter 2 - aptamer technology for the detection of foodborne pathogens and toxins. Advanced Biosensors for Health Care Applications. Elsevier, pp 45–69
Shahrokhian S, Ranjbar S (2018) Aptamer immobilization on amino-functionalized metal–organic frameworks: an ultrasensitive platform for the electrochemical diagnostic of Escherichia coli O157: H7. Analyst 143(13):3191–3201
Zhu X et al (2015) Effective adsorption and enhanced removal of organophosphorus pesticides from aqueous solution by Zr-based MOFs of UiO-67. ACS Appl Mater Interfaces 7(1):223–231
Scharff RL (2015) State estimates for the annual cost of foodborne illness. J Food Prot 78(6):1064–1071
Dai G et al (2019) Electrochemical determination of Salmonella typhimurium by using aptamer-loaded gold nanoparticles and a composite prepared from a metal-organic framework (type UiO-67) and graphene. Microchimica Acta 186(9):1–9
Lee S-C et al (2017) Sensitive fluorescent imaging of Salmonella enteritidis and Salmonella typhimurium using a polyvalent directed peptide polymer. Microchimica Acta 184(8):2611–2620
Turner NW et al (2015) Analytical methods for determination of mycotoxins: an update (2009–2014). Anal Chim Acta 901:12–33
Weaver AC, Adams N, Yiannikouris A (2020) Invited review: use of technology to assess and monitor multimycotoxin and emerging mycotoxin challenges in feedstuffs. Appl Anim Behav 36(1):19–25
Zahra N et al (2019) A review of mycotoxin types, occurrence, toxicity, detection methods and control: review: review of mycotoxin types. Biol Sci 62(3):206–218
Zeng X et al (2020) Modulation of tumor microenvironment by metal-organic-framework-derived nanoenzyme for enhancing nucleus-targeted photodynamic therapy. Nano Research 13(6):1527–1535
Tola M, Kebede B (2016) Occurrence, importance and control of mycotoxins: a review. Cogent Food Agric 2(1):1191103
Zolfaghari H, Khezerlou A (2020) Detoxification of aflatoxin B1 by probiotic yeasts and bacteria isolated from dairy products of Iran. Adv Pharm Bull 10(3):482–487
Anater A et al (2016) Mycotoxins and their consequences in aquaculture: a review. Aquaculture 451:1–10
Zain ME (2011) Impact of mycotoxins on humans and animals. J Saudi Chem Soc 15(2):129–144
Hussein HS, Brasel JM (2001) Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 167(2):101–134
Schothorst RC, van Egmond HP (2004) Report from SCOOP task 3.2. 10 “collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states”: Subtask: trichothecenes. Toxicol Lett 153(1):133–143
Wu Q et al (2020) An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment. Arch Toxicol 94(11):3645–3669
Zhao X et al (2021) A fluorescence aptasensor based on controlled zirconium–based MOFs for the highly sensitive detection of T–2 toxin. Spectrochim Acta A Mol Biomol Spectrosc 259:119893
Lee HJ, Ryu D (2017) Worldwide occurrence of mycotoxins in cereals and cereal-derived food products: public health perspectives of their co-occurrence. J Agric Food Chem 65(33):7034–7051
Xue-Mei Z et al (2019) Screening of oligonucleotide aptamers and application in detection of pesticide and veterinary drug residues. Chin J Anal Chem 47(4):488–499
Luan Y et al (2020) Advances in the application of aptamer biosensors to the detection of aminoglycoside antibiotics. Antibiotics 9(11):787
Chen M et al (2017) A novel aptamer-metal ions-nanoscale MOF based electrochemical biocodes for multiple antibiotics detection and signal amplification. Sens Actuators B 242:1201–1209
Wen J et al (2021) Ultrasensitive ECL aptasensing of kanamycin based on synergistic promotion strategy using 3,4,9,10-perylenetetracar-boxylic-l-cysteine/Au@HKUST-1. Anal Chim Acta 1180:338780
Wei X et al (2013) Fluorescence biosensor for the H 5 N 1 antibody based on a metal–organic framework platform. J Mater Chem B 1(13):1812–1817
Peng Y et al (2014) Metal-organic framework nanosheets as building blocks for molecular sieving membranes. Science 346(6215):1356–1359
Timothy N’a, Williams ET (2019) Environmental pollution by heavy metal: an overview. Chemistry 3(2):72–82
Borrill AJ, Reily NE, Macpherson JV (2019) Addressing the practicalities of anodic stripping voltammetry for heavy metal detection: a tutorial review. Analyst 144(23):6834–6849
Khezerlou A et al (2021) Assessment of heavy metal contamination and the probabilistic risk via salad vegetable consumption in Tabriz, Iran. Biol Trace Elem Res 199(7):2779–2787
USEPA E (2013) Regional screening level (RSL) summary table (TR= 1E− 6, HQ= 1)
Boudebbouz A et al (2021) Heavy metals levels in raw cow milk and health risk assessment across the globe: a systematic review. Sci Total Environ 751:141830
De Toni L et al (2017) Phthalates and heavy metals as endocrine disruptors in food: a study on pre-packed coffee products. Toxicol Rep 4:234–239
Tudi M et al (2021) Agriculture development, pesticide application and its impact on the environment. Int J Environ Res Public Health 18(3):1112
Abdollahdokht D et al (2022) Conventional agrochemicals towards nano-biopesticides: an overview on recent advances. Chem Biol Technol Agric 9(1):1–19
Cooper J, Dobson H (2007) The benefits of pesticides to mankind and the environment. Crop Prot 26(9):1337–1348
Ramankutty N et al (2018) Trends in global agricultural land use: implications for environmental health and food security. Annu Rev Plant Biol 69(1):789–815
Singh NS et al (2018) Pesticide contamination and human health risk factor. In: Modern age environmental problems and their remediation. Springer, pp 49–68
Rani L et al (2021) An extensive review on the consequences of chemical pesticides on human health and environment. J Clean Prod 283:124657
Wang N et al (2022) Aptamer-binding zirconium-based metal-organic framework composites prepared by two conjunction approaches with enhanced bio-sensing for detecting isocarbophos. Talanta 236:122822
Liu Q et al (2020) Magnetically controlled colorimetric aptasensor for chlorpyrifos based on copper-based metal-organic framework nanoparticles with peroxidase mimetic property. Microchimica acta 187(9):1–9
Cverenkárová K et al (2021) Microplastics in the food chain. Life 11(12):1349
Allsop TD et al (2019) An ultra-sensitive aptasensor on optical fibre for the direct detection of bisphenol A. Biosens Bioelectron 135:102–110
Song Y et al (2020) Ultrasensitive detection of bisphenol A under diverse environments with an electrochemical aptasensor based on multicomponent AgMo heteronanostructure. Sens Actuators B 321:128527
Olatunde A et al (2022) Vanillin: A food additive with multiple biological activities. Eur J Med Chem 5:100055
Anuradha K, Shyamala BN, Naidu MM (2013) Vanilla-its science of cultivation, curing, chemistry, and nutraceutical properties. Crit Rev Food Sci Nutr 53(12):1250–1276
Pérez-Cejuela HM, Herrero-Martínez JM, Simó-Alfonso EF (2020) Recent advances in affinity MOF-based sorbents with sample preparation purposes. Molecules 25(18):4216
Imaz I et al (2011) Metal–biomolecule frameworks (MBioFs). Chem Commun 47(26):7287–7302
Acknowledgements
The research protocol was approved and supported by the Student Research Committee, Tabriz University of Medical Sciences (grant number: 68658). Also, this study has been approved and supported by Department of Food Science and Technology, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. We gratefully acknowledge their assistance.
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Tavassoli, M., Khezerlou, A., Khalilzadeh, B. et al. Aptamer-modified metal organic frameworks for measurement of food contaminants: a review. Microchim Acta 190, 371 (2023). https://doi.org/10.1007/s00604-023-05937-2
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DOI: https://doi.org/10.1007/s00604-023-05937-2