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Synthesis of nanoparticles via microfluidic devices and integrated applications

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Abstract

In recent years, nanomaterials have attracted the research intervention of experts in the fields of catalysis, energy, biomedical testing, and biomedicine with their unrivaled optical, chemical, and biological properties. From basic metal and oxide nanoparticles to complex quantum dots and MOFs, the stable preparation of various nanomaterials has always been a struggle for researchers. Microfluidics, as a paradigm of microscale control, is a remarkable platform for online stable synthesis of nanomaterials with efficient mass and heat transfer in microreactors, flexible blending of reactants, and precise control of reaction conditions. We describe the process of microfluidic preparation of nanoparticles in the last 5 years in terms of microfluidic techniques and the methods of microfluidic manipulation of fluids. Then, the ability of microfluidics to prepare different nanomaterials, such as metals, oxides, quantum dots, and biopolymer nanoparticles, is presented. The effective synthesis of some nanomaterials with complex structures and the cases of nanomaterials prepared by microfluidics under extreme conditions (high temperature and pressure), the compatibility of microfluidics as a superior platform for the preparation of nanoparticles is demonstrated. Microfluidics has a potent integration capability to combine nanoparticle synthesis with real-time monitoring and online detection, which significantly improves the quality and production efficiency of nanoparticles, and also provides a high-quality ultra-clean platform for some bioassays.

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Funding

This project was supported by the National Natural Science Foundation of China (Grant Nos. 22174133, 12274386, 51832005, 62075203, and 1210042018) and Zhejiang Provincial Natural Science Foundation of China (No. LGF21F050002), and the Preeminence Youth Science Funds of Zhejiang Province (No. LR19F050001), the National Key R&D Plan (No.2021YFC3340400), and the Key R&D Plan of Zhejiang Province (Nos. 2022C01127 and 2021C05005).

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Authors and Affiliations

  1. College of Metrology and Measurement Engineering, China Jiliang University, Hangzhou, 310000, People’s Republic of China

    Fuqi Yao, Pengpeng Zhu, Junjie Chen & Qiang Chen

  2. College of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310000, People’s Republic of China

    Suyang Li & Pei Liang

  3. School of Electrical and Information Engineering, Tianjin University, Tianjin, 300072, People’s Republic of China

    Biao Sun

  4. College of Information Engineering, China Jiliang University, 310018, Hangzhou, 310000, People’s Republic of China

    Yunfeng Li

  5. Chinese Academy of Inspection and Quarantine (CAIQ), 100123, Beijing, People’s Republic of China

    Mingqiang Zou & Xiaohua Qi

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Yao, F., Zhu, P., Chen, J. et al. Synthesis of nanoparticles via microfluidic devices and integrated applications. Microchim Acta 190, 256 (2023). https://doi.org/10.1007/s00604-023-05838-4

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